According to Samus herself, and as demonstrated in one of the trailers, the best way to deal with Zebesians is to give them a good kick in the face.
Anthony Higgs's line "Remember me?" from the Other M trailer at E3 soon became an instant meme, because nobody knew who in the hell he was, nor did he appear in any Metroid game until then. The puzzling nature of the memetic line had garnered Anthony the (temporary) Fan Nickname, Mysterious Black Dude.
In a Shout Out to Metal Gear Solid, when Samus dies, Adam screams "Samus, what's going on?! Respond! RESPOOOND!"
Anthony Higgs killstealing from Samus, and Samus's reaction. She punches his shoulder in annoyance. (She punches him again when he mocks her signature "thumbs-down" just before the credits.)
Right before that, the creature attacking Samus Ridley's adolescent form is defeated... when it slams face-first into a wall disguised by a hologram. In bullet time.