Fighting Ridley by standing underneath him is both terrifying and hilarious. You'll have no idea how he still hasn't killed you yet.
Get the Super Missiles ahead of time, and it's possible to kill Kraid in just four shots and two seconds. Hello Kraid. Goodbye Kraid.
There's a robot blocking a hallway in the Pirate Mothership that walks really slowly. REALLY slowwlllyyyy. So how do you get him to speed up when you're in a hurry? Simple, shoot missiles at him. He instantly quickens his pace. Yet if you drop a Power Bomb... he barely reacts.