A meta-example from the production of the movie: Just before shooting the scene where the group runs through a dirty, trash-filled alley, the Toronto Sanitation department came by and cleaned it all up, so the crew had to dig through local dumpsters for more trash to make up for the loss!
When Darryl is very obviously blackmailing Chris to bring him along, Sara has a very efficient solution.
Chris: What do I do?
Sara: Get in the car and run him over.
One funny moment occurs when the group discusses the subject of money.
Brad: Where we gonna get 50 bucks? Sara: We could sell Daryl. Ya' think?
Brenda gets in a bad situation in the bus station.
Brenda: Chris I'm begging you, it's really scary here. I've just seen three people shoot up, a bald Chinese lady with no pants on, and there's this old guy outside who wants his bedroom slippers! (Then the old man starts banging on telephone booth.) Old Man: Get out of my house! (Brenda kicks out his box and his slippers.) Brenda: You just moved!
And later another homeless person tells him to get out of her house.
Then there's the scene when the gang is at the hospital and everyone thinks Brad is dead. Then Brad pops up out of nowhere.
Brad: Daryl, why are you hugging me? Daryl: Brad don't you ever die on me! Ever! Brad: O.K. I won't.
While riding with 'Handsome' John Pruitt, who has a Hook Hand and claims he keeps his severed hand in the glove compartment. What he actually keeps in the glove compartment, however...
Pruitt: Watch out, kids!
(opens glove compartment)
Daryl: Oh, God!
(Pruitt pulls out a Revolver)
Daryl: (covering his eyes) Is it a hand?!?
Brad: (shocked) No.
Daryl: (relieved) Oh, good!
Brad: It's a gun.
Daryl: Oh, God!
After Brad refuses to pummel Chris's cheating boyfriend because he "won't sink to his level", we get this gem:
Daryl: I will!
Even funnier, because Daryl felt fully justified, not only because the guy cheated on Chris, but because earlier in the movie we're told that said boyfriend once pummeled Daryl for touching his car, something Daryl denied doing. The crowning part is Daryl kicking him in the ass like the guy did to Daryl.