Spider-Man was active for a while before his mutation disease became apparent in Season 2. Seems to come out of nowhere. However, in "Night of the Lizard", Spidey activated the Neogenic Recombinator to restore the Lizard to human form. Spidey was in close proximity at the time and is clearly reacting to the energy burst.
In "The Wedding", Scorpion seems all-too eager to do Smythe's bidding — even referring to him as "Mr. Smythe". This despite being his captive in "Partners". Is it just because Smythe fixed his malfunctioning suit? Remember what Scorpy said in "Partners", however: "Smythe knows how to change me back."
In Spider-Man: The Animated Series, Spider-Man meets and becomes friends with a young girl who is his "biggest fan". Naturally they end up on an adventure, and at the end of the story arc she asks to see his real face; Parker relents and reveals his identity to the girl, who promises to keep it a secret for the rest of her life. A few minutes later, we see Peter leaving the Make a Wish Foundation for Terminally Ill children. The connection is made more explicit in the original comic the episode was based on.
Sounds more like Fridge Sadness.
Subverted, when you realize She was the person to keep him going despite the damage he did, she was the 'Uncle Ben' of the episode.
Quite the subtle one in the Seven Spider-Men arc: one of the Spider-Mens wears Doctor Octopus' tentacles, which he says he took as a souvenir after a fight with Doc Ock. Remember that those tentacles were actually fused to Doc's spine. Imagine what that Spider-Man must have done to get them.
Not necessarily. The arms that that Spidey was using had a different design than Doc Ock's, and even the regular Spidey's universe had Doctor Octopus build a robot with arms like his own at least once. That in mind, it seems much more likely that Doctor Octopus had build another set of his iconic arms for some purpose, and that universe's Spiderman simply ended up with them somehow.
Now think about it in light of the sinister Spider-man reveal.
I never assumed that Spider-Man had fused the tentacles onto himself. He's wearing a headband similar to that worn by Doctor Octopus when he operated the Octobots via remote control. Furthermore, attached to the headband is a set of goggles, presumably with a heads-up display built into them. If the arms were fused to him, why would Spider-Man need this stuff?
You need to read the limited series "Funeral for an Octopus." After Doc Ock is killed by Kaine, his arms are studied by the government, and they develop a device that fools them into thinking that one´s brain patterns are Ock´s, who only worked because they were messed up to begin with. The Sinister Six try to steal them, and guess what Spidey does? Yeah, put them on and use them to beat all six of them. After that, the headband is broken and he cannot control them, so he has to rip them apart. The thing is that the device worn by Octo-Spidey in the animated series is identical, which takes us to the next question: did Ock suffer the same fate in that universe?
It's always possible that that universe's Doc Ock never had the arms fused to him in the first place. It's a different universe, can't assume everything's the same.
"Jonah, Kassady's not a man, he's a monster. He's done things even the post wouldn't print." Make of that what you will.