Crowning Music of Awesome: Every single song in the game. For a leitmotif said to consist of two repetitive notes, it's awfully catchy. Also, notable mention goes to Everything's Alright, the game's Award Bait Song entry.
Neil's adamant defense of Johnny and River being united the way they were.
Eva: Look, our contract is to send him to the moon. And the only way for that to happen is if Johnny is motivated to do so.
Neil: But if that means removing River, then what's the point?! The only reason he wants to go to the moon is because she died!