These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
YMMV: To The Moon
Award Bait Song: Everything's Alright. Covers every single traits of the trope squarely and then some.
Fridge Brilliance: Why didn't River just tell John about their first meeting, without going through the whole rabbit ordeal? At first it seems that it's only due to her Asperger's, but revisiting the first part of the story, it becomes apparent that she wanted, in her own way, to bridge the gap between them by reminding him of (arguably) the only time when they truly connected, and that wouldn't work unless he remembered on his own.
Fridge Horror: More like Fridge Depression: because they're only changing memories, not the past, the real Johnny dies never knowing what his wife was trying to tell him, and the real River dies knowing Johnny never understood/remembered what she kept trying to hint at. Well, assuming any of it was ever real to begin with.
During The Stinger, it's implied that Neil might be dying. And once you think about it, you come to understand why he's constantly acting immature, doing stupid things, being mean, jerkish and funny: He's trying to make the most out of life before he dies...
It's implied that all of the game's events in fact take place in Neil's head, quite possibly while he is in a similar state to John. Consider the Deja Vu of the squirrels running along the same path twice, almost like a glitch in the matrix.
The first theory is further hinted at the very beginning of the game, in an optional scene you could miss entirely if you played as Eva: the mock RPG fight against the squirrel. If you check Neil's health bar, you'll see it's not full. If you play with Eva, the bar will be full.
To support the theory that Neil is dying, at the carnival when they meet the fortune-teller, Neil refuses to see his future. "Good or bad, I'd be s***ed either way."
The Woobie: Joey. Also River. And depending on how you interpret the implications, Neil.
Unfortunate Implications: Despite Asperger syndrome being depicted in a realistic, understanding, and sympathetic light, it's too unspeakable of to mention by name.
Revealing what it is would immediately color the perceptiosn of the Internet, which has its own preconceived stereotypes about the condition. By not bringing that up, it helps to simply show what it is, no baggage attached.