The finale: the ship is self-destroying, Susan is depowered, her friends are trapped...
Gallaxhar: "And there is nothing you can do about it, Susan."
Susan: "I'm not so sure. And the name? Is Ginormica."
She then fires that alien blaster so a flippin' elephant-sized SPHERE full of alien Phlebotinum smashes and breaks on her, repowering herself in the process, goes Mama Bear to rescue her monster mash, pulling off a literal Big Damn Hero moment as the ceiling collapses, gathers the monsters up in her arms, and tears her way through the ship then SKY DIVES off it, when the UFO is probably two kilometers or more in the sky. I'm sorry, Pixar, but Ginormica just had the biggest Crowning Moment of Awesome of any CGI heroine yet, even if your movies are better quality...
And her very public dumping of Derek.
Susan: Are the cameras rolling, sweetie??
Derek: Why, of course they are!
Susan: (grabs him) Good. Because I wouldn't want your fans to miss this!