Several characters were reimagined in the Ultimate Marvel universe in a different species than their originals.
- Ultimate Galactus Trilogy
- Gah Lak Tus is not a universal cosmic being, but just a robot hive-mind.
- The Sentry is adapted as a high detail telescope.
- Ultimate Spider-Man (2000):
- Due to being a Composite Character with Firestar, Liz Allan is a mutant instead of a regular human.
- Morbius is usually an artificial vampire. This version, possibly due to being Dracula's brother, is a true vampire.
- Ultimate X-Men (2001)
- Both John Wraith and Doug Ramsey are humans, not mutants.
- Juggernaut in 616 is often mistaken for a mutant, and his brother (Xavier) is, but his power actually comes from a magic ruby. Here he actually is a mutant.
- Instead of being interdimensionial beings, Mojo's a human and Longshot is a mutant. Spiral is also a mutant, too, instead of a human who was turned into a mutated cyborg.
- Lilandra Neramani is the human leader of a Church of Happyology called Shi’ar Enlightenment, rather than the alien ruler of the Shi'ar Empire.
- Hard-Drive, a minor Inhuman in the mainline canon, appears in Ultimate War as a member of Magneto's Brotherhood, implying she's a mutant in this continuity (the Ultimate Inhumans left the planet in their first appearance).
- Lorelei, a mutated human, is now simply a mutant.
- The Ultimates:
- The Wasp is a mutant who was born with her abilities, in contrast to the mainstream comics, where she's a human who gained superpowers through scientific experimentation.
- There are several different versions of The Vision, but the one from the West Coast Ultimates is a cyborg rather than a Ridiculously Human Robot.
- Abigail Brand appears to be a regular human with dyed green hair, rather than a mutant/alien Half-Human Hybrid.
- Ultimate Fantastic Four: The Awesome Android is a cyborg rather than an android. Specifically he's the Mad Thinker's brother, who she converted into a cybernetic assistant after cutting out some of his brain and grafting it onto her own.
