History ShoutOut / TheBindingOfIsaac

* One of the new achievements for ''Afterbirth+'' is titled [[Franchise/FiveNightsAtFreddys Five Nights at Mom's.]]

-->''The pickup quote "Game breaking bug, right away!" is a reference to a quote by Phil Fish in ''[[Film/IndieGameTheMovie Indie Game: The Movie]], ''where he says the exact same words when a bug is discovered in FEZ on the first day it is being shown at PAX. This has been confirmed by Edmund himself on [[https://twitter.com/edmundmcmillen/status/666029976920043520 twitter]].''

* Booster Pack #3 also features a new shop item called Mr. ME! Its tagline is [[WesternAnimation/RickAndMorty "Caaan Do!"]]
* Booster Pack #3 also added the Door Stop trinket. It's tagline is [[Series/GameOfThrones "Hold the door!"]]

** ''Afterbirth'' adds even more babies, including [[Franchise/SuperMarioBros Mario]], [[Franchise/MegaMan Mega Man]], Disney/MickeyMouse, Anime/AstroBoy, [[TabletopGame/{{Warhammer 40000}} an Imperial Space Marine, a Chaos Space Marine]], a Franchise/{{Gundam}}, the [[VideoGame/FinalFantasyI Warriors of Light]], [[Franchise/FridayThe13th Jason Voorhees]], a Franchise/KamenRider, [[VideoGame/PacMan Pac-Man]], [[Film/ThreeHundred King Leonidas]], [[WesternAnimation/TeenageMutantNinjaTurtles The Shredder]], and many, many more.

** ''Rebirth'' also adds the iconic "[[http://magiccards.info/al/en/232.html Black Lotus]]" to the list of items you can get.

** ''Afterbirth+'' adds three more unlockable cards: Era Walk, based on [[http://gatherer.wizards.com/Pages/Card/Details.aspx?multiverseid=383131 Time Walk]], Ancient Recall, based on [[http://gatherer.wizards.com/Pages/Card/Details.aspx?multiverseid=382841 Ancestral Recall]], and Huge Growth, based on [[http://gatherer.wizards.com/Pages/Card/Details.aspx?multiverseid=442161 Giant Growth]].

** Additionally,the Sisters Vis,the bosses of the third area in Gish,can appear as a boss in the Depths.

* Crack The Sky is a reference to ''Theatre/KingLear'', but also to an album of the same name by M]usic/{{Mastodon}}.

* ''Afterbirth'' added an item called Black Powder which lets you draw circles of the eponymous substance to form pentagrams that deal damage to enemies standing in the area, with the description [[Music/PearlJam "Spin the black circle."]] (The song itself being about the singer's [[NewMediaAreEvil preference for vinyl records]])

* The first booster pack for ''Afterbirth+" saw the addition of Bozo, an item that paints Isaac as a SadClown. This item is, of course, a reference to [[https://en.wikipedia.org/wiki/Bozo_the_Clown Bozo the Clown]], a popular TV character during the 60's and 70's.

** ''Afterbirth +'' added a fairy that flies towards tinted rocks, entrances to hidden rooms, and rocks hiding trapdoors. The name? [[VideoGame/TheLegendOfZeldaOcarinaOfTime YO LISTEN!]]

** ''Afterbirth +'' adds three more unlockable cards: Era Walk, based on [[http://gatherer.wizards.com/Pages/Card/Details.aspx?multiverseid=383131 Time Walk]], Ancient Recall, based on [[http://gatherer.wizards.com/Pages/Card/Details.aspx?multiverseid=382841 Ancestral Recall]], and Huge Growth, based on [[http://gatherer.wizards.com/Pages/Card/Details.aspx?multiverseid=442161 Giant Growth]].

** ''Afterbirth +'' adds a challenge revolving around this item known as "Pokey Mans", as well as the [[VideoGame/PokemonGo Poke Go,]] which sometimes spawns a friendly enemy in a room with the message "A charmed [enemy name] has appeared!"
** ''Afterbirth +'' also adds a metronome item that copies a passive item for a room when used with the pickup text reading "Waggle a finger". This is a nod to the Metronome attack in the Pokémon games.

* One of the new achievements for ''Afterbirth +'' is titled [[Franchise/FiveNightsAtFreddys Five Nights at Mom's.]]

* One of the items introduced in ''Afterbirth +" looks exactly like the classic [[https://bindingofisaacrebirth.gamepedia.com/Butter_Bean Butter Bean]], but is actually a unique item called [[https://bindingofisaacrebirth.gamepedia.com/Wait_What%3F Wait What?]]. The flavor text for this item states that "[[https://en.wikipedia.org/wiki/I_Can%27t_Believe_It%27s_Not_Butter! I can't believe it's not Butter]] Bean!"

* The first booster pack for ''Afterbirth +" saw the addition of Bozo, an item that paints Isaac as a SadClown. This item is, of course, a reference to [[https://en.wikipedia.org/wiki/Bozo_the_Clown Bozo the Clown]], a popular TV character during the 60's and 70's.
* A new item added in the second booster pack for ''Afterbirth +'' is Leprosy. Its tagline? ''[[Film/TheRoom You're tearing me apart!]]''

** There are multiple references to the classic "Gotta catch 'em all" slogan, such as the Meat Cube's flavor text reading "Gotta meat em all" or the Jar of Flies' flavor text reading "Gotta catch 'em all?"

* '''Subverted''' in the case of Gluttony. A lot of fans think that his appearance and the blood-laser that shoots from the stomach are references to ''Manga/FullmetalAlchemist''; HOWEVER, [[WordOfGod Edmund McMillen]] himself has stated several times that the resemblance is purely coincidental, because he has never watched (nor even heard of, prior to the game's release) ''Fullmetal Alchemist''.

* Crack The Sky is a reference to ''Theatre/KingLear'', but also to an album of the same name by Music/{{Mastodon}}.

* ''Afterbirth'' added an item called Black Powder which lets you draw circles of (what else?) black powder to form pentagrams that deal damage to enemies standing in the area. Its in-game hint text? [[Music/PearlJam Spin the black circle.]]

* Crack The Sky is a reference to KingLear, but also to an album of the same name by Music/{{Mastodon}}.

* Booster Pack #3 features a new anger room item in the form of a prism [[Music/PinkFloyd eclipsed by the moon.]]

* A new item added in the second booster pack for ''Afterbirth +'' is Leprosy. Its tagline? [[Film/TheRoom ''You're tearing me apart!'']]

** For some reason, TheStinger of Ending 14 tells you to [[spoiler:get in the box.]] [[spoiler:In fact, Isaac's relation with the chest and who is inside it is reminiscent of Steven and the box.]]

* An item named "Telepathy for Dummies," looking exactly like any ''"[[http://en.wikipedia.org/wiki/For_Dummies For Dummies]]"'' book would look like.

** On the EasterEgg front, the card you pick up is a Black card with the caption "Something stinks...". When you unlock it in a new save, the card shown is a White card saying "a room full of poop."

* Lazarus is characterized by his red hair. [[TimeEnoughForLove Much like another fictional character who uses the name]].

* [[http://bindingofisaacrebirth.gamepedia.com/Spider_Mod Spider Mod]] is a reference to ''Spidermod'', an extensive GameMod for the original ''The Binding of Isaac''. Its creator, Spider853, [[PromotedFanboy was a lead-developer]] for ''Rebirth''.

* The second phase of the boss [[spoiler:Mega Satan]] has a significant resemblence to the [[VideoGame/{{Doom}} Icon of Sin]].

** For some reason, TheStinger of the final ending tells you to [[spoiler:get in the box.]] [[spoiler:In fact, Isaac's relation with the chest and who is inside it is reminiscent of Steven and the box.]]

* The second phase of the boss [[spoiler:Satan]] has a significant resemblence to the [[VideoGame/{{Doom}} Icon of Sin]].

* Crack The Sky is a reference to KingLear, but also to an album of the same name by {{Mastodon}}.

* The description of the Louse (a trinket) reads: "[[VideoGame/ResidentEvil ''Itchy. Tasty...'']]"