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1* ''Franchise/SuperMarioBros'':
2** The 1-up mushroom that follows you around is green with white spots.
3** The Magic Mushroom and the Mini Mush are direct references to Mario's Super Mushroom and Mini Mushroom.
4** The Bobby-Bomb walking bomb upgrade is a clear reference to Bob-Omb.
5** One of Rebirth's items allows you to jump. What does it look like? A copy of the original Super Mario Bros.
6** Rebirth has an item called Gnawed Leaf that gives Isaac a raccoon tail and lets him turn into a statue.
7** The description of the Liberty Cap is "[[VideoGame/YoshisIsland Touch fuzzy, get dizzy]]".
8** One of the messages dispensed from the Fortune Teller is "Your princess is in another castle".
9** Collecting enough mushrooms in ''Afterbirth'' turns you into a mushroom-person, strikingly similar to a Toad.
10** ''Repentance'' adds the Mega Mush, and just like the [[VideoGame/NewSuperMarioBros Mega Mushroom]], it turns Isaac gigantic and allows him to defeat nearly every enemy just by running into them.
11* ''Franchise/TheLegendOfZelda'':
12** The game's logo is very reminiscent of the [[VideoGame/TheLegendOfZeldaI first game's]]. The Japanese logo for ''Rebirth'' is instead a parody of the logo for ''VideoGame/TheLegendOfZeldaALinkToThePast'', with a pentagram replacing the Tri-Force.
13** The HUD and basic rooms are very blatant ones to ''VideoGame/TheLegendOfZeldaI''.
14*** In ''Rebirth'', alternate trapdoors can send you to underground rooms that are just as blatant.
15** Many enemies are also reminiscent of ''Zelda'' enemies. The most noticeable are the Chargers (which behave like Ropes), Knights (which behave like Darknuts), and Pokys (which behave like Traps).
16*** ''Rebirth'' added Mom's Hands (which behave like Wallmasters) and Bonies (which behave like Stalfos).
17** Teleportation items may randomly send you to a room with a guy saying "[[VideoGame/ZeldaIITheAdventureOfLink I AM ERROR.]]"
18** ''Wrath of the Lamb'''s candle is pulled straight from ''VideoGame/TheLegendOfZeldaI''.
19** The Stepladder from the original Zelda's functionally identical counter-part, simply called "The Ladder."
20** Chub can be made to eat bombs to damage her, just like the Dodongo. ''Rebirth'' even adds a "Chub dislikes smoke!" line.
21** ''Afterbirth'' adds a new challenge called [[FunWithHomophones "I Rule!"]], which gives you the starting items of a sword, a shield, the Ladder, and the Boomerang.
22** ''Afterbirth+'' added a fairy that flies towards tinted rocks, entrances to hidden rooms, and rocks hiding trapdoors. The name? [[VideoGame/TheLegendOfZeldaOcarinaOfTime YO LISTEN!]]
23** ''Repentance'' adds the Spirit Sword, which gives Isaac a sword he can swing in front of himself. By holding down fire and then releasing, it unleashes a spin attack, and when Isaac is at full health, it throws out a SwordBeam, much like how the Master Sword typically does. To drive the point further, you unlock it by completing the Isaac's Awakening challenge, which starts you off with the Spirit Sword, the Trinity Shield, and Mom's Bracelet, which functions similarly to the Power Bracelet. The challenge ends with the fight against Mother, who has a TennisBoss attack just like endgame ''Zelda'' bosses usually do.
24* ''{{Franchise/Castlevania}}'':
25** When going into the OneWingedAngel form accessible through one of Eve's starting items, the transformation is denoted by the phrase [[VideoGame/CastlevaniaIISimonsQuest "What a horrible night to have a curse"]].
26*** The Empress card normally transforms you into the same demon Eve becomes. In ''Repentance'', the reverse Empress card instead turns you into Magdalene, with the message "The morning sun has vanquished the horrible night."
27** One of Death's attacks is [[Franchise/{{Castlevania}} scattering spinning sickles all over the room, which fly towards the player]]. In ''Rebirth'', the player can find Death's Touch, which turns tears into the very same sickles.
28%%** One of the projectile upgrades is Haemolacria — in other words, Bloody Tears.
29** The Holy Water subweapon is available as a Familiar, and functions similarly to its Castlevania counterpart, leaving behind a puddle that will damage enemies. ''Repentance'' buffed it to be even more like the original, since it's now thrown at enemies rather than shattering when Isaac takes damage. It even has unique synergies with both BFFS! and Fire Mind, which both cause the Holy Water to leave behind a blue fire, completing the reference.
30** The Mask of Infamy bears an intentional resemblance to the recurring boss [[VideoGame/CastlevaniaIISimonsQuest Carmilla]].
31
32* ''VideoGame/MeatBoy'':
33** One of the endings: [[spoiler:Isaac dresses as Dr. Fetus from ''Super Meat Boy'', complete with the stage title theme from that game. Unsurprisingly, the ending gives you the Fetus in a Jar powerup.]] There's also a power-up called "Doctor's Remote," which is another reference to the character in question.
34** C.H.A.D. can appear as an alternate version of Chub.
35** Meat Boy himself appears as a {{familiar}} when you collect Cubes of Meat, and ''Wrath of the Lamb'' adds a "SMB Super Fan" circular saw item that transforms the player character into a Meat Boy lookalike.
36** The Larry Jr. boss is presumably related in some way to Larries' Lament from the second-to-last world of Super Meat Boy — possibly meant to be the miniature versions of them that pop out of their head in the ending.
37** ''Rebirth'' has Bandage Girl appear as a familiar when you collect balls of bandages.
38** A more meta one: the achievements for completing floors without getting hit in this game follow a scheme of "____ Boy", which is the same pattern that the achievements for completing worlds without dying in ''Super Meat Boy'' followed.
39** One of the new bosses introduced in ''Afterbirth'' is [[http://bindingofisaacrebirth.gamepedia.com/Little_Horn Little Horn]], not to be confused with ''Super Meat Boy's'' [[http://supermeatboy.wikia.com/wiki/Little_Horn Little Horn]].
40* ''TableTopGame/MagicTheGathering'':
41** One of the Devil Room items in the original game is "[[https://scryfall.com/card/ima/96/lord-of-the-pit Lord of the Pit]]", which turns Isaac into a black-winged demon similar to the one depicted on the card.
42** One of the powerups you can get from the Devil Room in ''Wrath of the Lamb'' is "[[http://magiccards.info/mr/en/44.html Spirit of the Night]]", which changes Isaac's face to look like the card of the same name.
43** The Beginner Deck item in ''Rebirth'' is a reference to pre-built decks, and it tattoos the "[[http://mtgsalvation.gamepedia.com/Color_Pie color pie]]" on Isaac's forehead whenever you take it.
44** ''Rebirth'' also adds the iconic "[[http://magiccards.info/al/en/232.html Black Lotus]]" and to the list of items you can get. Fittingly, it's one of the rarest items in the game and has a strong and generically useful effect.
45** Also from ''Rebirth'', we have the Chaos Card, which is a reference to the infamous [[http://magiccards.info/ced/en/237.html Chaos Orb]].
46** Again from ''Rebirth'' is the item [[https://scryfall.com/card/sum/97/contract-from-below Contract from Below]].
47** From ''Afterbirth'', the Rag Man enemy was inspired by [[http://gatherer.wizards.com/Pages/Card/Details.aspx?multiverseid=1740 the card of the same name.]]
48** ''Afterbirth+'' adds three more unlockable cards: Era Walk, based on [[http://gatherer.wizards.com/Pages/Card/Details.aspx?multiverseid=383131 Time Walk]], Ancient Recall, based on [[http://gatherer.wizards.com/Pages/Card/Details.aspx?multiverseid=382841 Ancestral Recall]], and Huge Growth, based on [[http://gatherer.wizards.com/Pages/Card/Details.aspx?multiverseid=442161 Giant Growth]]. These cards and Chaos Card also appear as a pixelated ''[=MtG=]'' card back when on the ground.
49** The Spindown Dice added in ''Repentance'' references the D20s used to track your life total in [=MtG=].
50** Booster Pack is a card counterpart to Mom's Coin Purse, dropping five random cards on pickup. Its appearance is specifically a ''Magic: The Gathering'' pack.
51* ''Franchise/{{Pokemon}}'':
52** A new item that appears in the ''Afterbirth'' DLC, the Friendly Ball, looks like and functions similarly to a Pokéball. It catches an enemy then releases them to fight for you.
53*** ''Afterbirth+'' adds a challenge revolving around this item known as "Pokey Mans".
54** ''Afterbirth+'' also adds [[VideoGame/PokemonGo Poke Go]], which sometimes spawns a friendly enemy in a room with the message "A charmed [enemy name] has appeared!"
55** ''Afterbirth+'' also adds a metronome item that copies a passive item for a room when used with the pickup text reading "Waggle a finger". This is a nod to the Metronome attack in the Pokémon games.
56** There are multiple references to the classic "Gotta catch 'em all" slogan, such as the Meat Cube's flavor text reading "Gotta meat em all" or the Jar of Flies' flavor text reading "Gotta catch 'em all?". The aforementioned Friendly Ball and Poke Go naturally also reference it with "Gotta fetch em all!" and "Gotta catch em..." respectively.
57** Completing the Boss Rush as Lazarus unlocks Missing No., a glitch-themed item named after a famous GlitchEntity from ''VideoGame/PokemonRedAndBlue''. ''Repentance'' would continue the trend with the item TMTRAINER and the trinket 'M, both of which are also named after ''Red and Blue'' glitches.
58** [[https://bindingofisaacrebirth.fandom.com/wiki/Plum_Flute Plum Flute]] looks suspiciously similar to the [[https://bulbapedia.bulbagarden.net/w/index.php?title=Poke_Flute Poké Flute]], with even Baby Plum's white wings and red body matching the Pokéball colour scheme.
59* ''VideoGame/{{Minecraft}}''
60** One of the new items in ''Wrath of the Lamb'' is the Notched Axe, a pickaxe that can be used to break rocks. This is a reference to ''VideoGame/{{Minecraft}}'' and its creator, Notch. In ''Repentance'', the item was reworked to work on a durability system that functions exactly like a ''Minecraft'' pickaxe.
61*** Both Book of Virtues and the Judas Birthright Book of Belial grant Notched Pickaxe ''Minecraft''-themed improvements. Virtues causes it mine coal, iron, gold, redstone, and diamond-themed wisps from rocks, which have effects based on their ''Minecraft'' equivalents. Belial gives Notched Axe a variety of bonus effects based on enhancements (increased durability (Unbreaking), faster attack speed (Efficiency), increased knockback (Knockback), burn damage (Fire Aspect), and more pickups from destroyed objects (Fortune)), including the purple glow overlay graphic that ''Minecraft'' uses.
62** There's an ''Afterbirth'' item called [[http://bindingofisaacrebirth.gamepedia.com/Mine_Crafter Mine Crafter]], which summons a TNT barrel (updated in ''Repentance'' to a TNT cube).
63* The Wrath boss is basically VideoGame/{{Bomberman}}. In addition, players will occasionally find a room styled after the mazes from Bomberman's multiplayer filled with bombs to collect.
64** Adding to this, the ''Afterbirth'' expansion adds the item Bomber Boy, which makes bombs explode in the Bomberman cross fashion. It even gives Isaac the little antenna that Bomberman uses on his helmet.
65* Steven, [[VideoGame/TimeFcuk a tiny head that grows out of your skull.]] He also appears as a boss.
66** His unlocking is the secret "something from the future", obtained by completing the basement [[Franchise/TheHitchhikersGuideToTheGalaxy 42]] times.
67** For some reason, TheStinger of Ending 14 tells you to [[spoiler:get in the box.]]
68* Many of the [[http://bindingofisaacrebirth.gamepedia.com/Babies multiplayer baby partners]] are shout outs, including [[VideoGame/{{Tetris}} many different Tetris blocks]], [[Franchise/{{Transformers}} Optimus Prime]], [[VideoGame/OneThousandAndOneSpikes Aban Hawkins]], [[VideoGame/{{Spelunky}} Spelunky Guy]], [[VideoGame/{{VVVVVV}} Captain Viridian and Upside-Down Captain Viridian]], [[VideoGame/SuperMeatBoy Dr. Fetus]], and [[VideoGame/TimeFcuk Steven again]].
69** ''Afterbirth'' adds even more babies, including [[Franchise/SuperMarioBros Mario]], [[Franchise/MegaMan Mega Man]], WesternAnimation/MickeyMouse, Anime/AstroBoy, [[TabletopGame/Warhammer40000 an Imperial Space Marine, a Chaos Space Marine]], a Franchise/{{Gundam}}, the [[VideoGame/FinalFantasyI Warriors of Light]], [[Franchise/FridayThe13th Jason Voorhees]], a Franchise/KamenRider, VideoGame/PacMan, [[Film/ThreeHundred King Leonidas]], [[Franchise/TeenageMutantNinjaTurtles The Shredder]], and many, many more.
70** ''Repentance'', of course, piles on a few more, including [[VideoGame/{{Monolith}} D-13]], [[VideoGame/{{Celeste}} a Golden Strawberry]], [[VideoGame/BabaIsYou Baba]], [[VideoGame/HollowKnight the Broken Vessel]], [[Website/{{Twitch}} the former PogChamp emote]], [[VideoGame/EnterTheGungeon a Bullet Kin]], [[WesternAnimation/MyLittlePonyFriendshipIsMagic Twilight Sparkle]], and [[VideoGame/OneShot Prototype]], as well as several references to prominent ''Binding of Isaac'' mods such as Bertran and Devil's Harvest.
71* A number of internet meme faces make an appearance, particularly the [[http://knowyourmeme.com/memes/forever-alone Forever Alone]] and [[http://knowyourmeme.com/memes/trollface-coolface-problem Troll Face]], with the latter appearing on bombs which are ready to go off. And let's not forget [[http://knowyourmeme.com/memes/shoop-da-whoop-i%E2%80%99m-a%E2%80%99-firin%E2%80%99-mah-lazer Shoop-Da-Woop!]], which is a charged laser weapon. There is also an enemy type with a distinctive trollface that will split in half upon receiving enough damage, and the duplicates will split further into even smaller copies, demonstrating the spirit, as well as appearance of the {{troll}}face. In its smallest form, it becomes a [[http://knowyourmeme.com/memes/poker-face Pokerface]]. Occasionally, the corpse sitting in one of the secret rooms will be sporting the "forever alone" face as well.
72%%* Names of the twin Gemini bosses - Suture and Contusion - seem to be a reference to a recurring lyric from the song "Cicatriz ESP" by Music/{{The Mars Volta}}.
73* One enemy type is the same species as VideoGame/{{Gish}}. Gish himself can appear as a boss as well, and drops [[spoiler:a baby version of himself (a familiar whose shots slow enemies)]] when defeated.
74** Additionally, the Sisters Vis, the bosses of the third area in ''Gish'', can appear as a boss in the Depths.
75** The floor Gehenna, an unlockable variant of Mausoleum, also draws visual inspiration from the 7 Planes of Hehenna, the chapter in Gish where the Vis Sisters were originally fought.
76* The "Pills Here!" message after picking up a pill is a shout out to ''VideoGame/Left4Dead''.
77* One effect that pills can give you is "[[VideoGame/DukeNukem Balls Of Steel]]," which gives you 2 soul hearts.
78* The null effect for pills is "I found pills!", with the fake effect "And ate them". This is likely a throwback to an early WebOriginal/{{LOLCat|s}} macro. The Horse Pill version makes Isaac's face resemble the "HURRR I'M A HOERS" meme.
79* The "My Little Unicorn" item seems to be a shout out to ''Franchise/MyLittlePony''.
80* The "Technology" upgrade is a clear reference to [[Franchise/StarTrek the Borg]].
81* That fly that buzzes around your head to intercept bullets is [[Music/TheOffspring Pretty Fly (for a White Guy)]].
82* The shovel item that lets you skip a floor is called "[[Film/{{Inception}} We Need To Go Deeper]]."
83* The Parasite power-up resembles the Parasite from the Flash-Game "VideoGame/TheVisitor" from fellow Newgrounds contributor Zeebarf.
84%%* The Chemical Peel item will give you a [[ComicBook/TwoFace Harvey Dent]] makeover.
85* One of the items is a book named "[[ParodiesForDummies Telepathy for Dummies]]", looking exactly like any ''"[[http://en.wikipedia.org/wiki/For_Dummies For Dummies]]"'' book .
86* One of the messages you can get from the Fortune Teller is "Look to La Luna." This was the clue on how to find Reptile in the original ''VideoGame/MortalKombat1992'' game. Two others, "MARRY AND REPRODUCE" and "STAY ASLEEP", reference ''Film/TheyLive''. It's also possible to get "[[VideoGame/MetalGear I feel asleep!!]]"
87* The Necronomicon's cover (which looks like a distorted or disfigured face) is the same as in ''Franchise/EvilDead''.
88* The Wire Hanger item is a reference to the film ''Literature/MommieDearest'', in which an abusive mother screeches the famous quote: "No more wire hangers ever!"
89* One of the new items in ''Binding of Isaac: Rebirth'' is the [[Film/AClockworkOrange Ludovico Technique]], which leaves Isaac's eyelids pulled back, as in the classic scene of Alex's reprogramming.
90* One of the items is a magnet that attracts consumables to your position. Its name? Comicbook/{{Magneto}}.
91* The Dople (a skinless Isaac's doppelganger in The Womb) is a reference to ''VideoGame/TombRaiderI'', where a skinless enemy who mirrored Lara's movements had to be killed by being lured into a lava trap, similar to how Doples can be lured into spikes.
92* Two new pill effects in ''Rebirth'' are "Lemon Party" (a reference to an infamous ShockSite) and "[[http://knowyourmeme.com/memes/are-you-a-wizard R U A WIZARD]]". (Lemon Party drops a very large, very damaging Lemon Mishap puddle, while R U A WIZARD gives Isaac temporary FishEyes that force him to fire each shot at a 45 degree angle instead of straight ahead.)
93* There's a little nod to a certain meme started/nourished by LetsPlay/{{Northernlion}}. "Rebirth Got Canceled" is one of the new Fortune Teller message, which was a popular joke statement back before the game's release, and a thinly-veiled TakeThat towards Phil Fish, who decided to cancel ''VideoGame/{{Fez}} 2'' after a particularly bad [[CreatorBreakdown meltdown]].
94* The "Anti-Gravity" item in Rebirth makes Isaac [[Comicbook/{{Watchmen}} light blue, with white eyes and an atomic insignia on his forehead]].
95%%* Samson's Chains in ''Rebirth'' attaches a ball-and-chain to character, like in ''VideoGame/{{NetHack}}'' or ''VideoGame/{{Spelunky}}''.
96* In ''Rebirth'', picking up the Transcendence item gives the message "[[Literature/{{IT}} We all float down here...]]"
97* One of the fortunes you can get is "[[Music/LouisArmstrong Nobody knows the troubles you have seen]]".
98* One of the card items in Rebirth is [[TabletopGame/CardsAgainstHumanity A Card Against Humanity]]. It fills the room with poop when you use it, referencing how the first Card Czar is chosen in the game's rules (whoever pooped last goes first).
99* Crack The Sky is a reference to ''Theatre/KingLear'', but also to an album of the same name by Music/{{Mastodon}}.
100* Two new pills added in ''Afterbirth'' are "One Makes You Larger" and "One Makes You Small", referencing the Music/JeffersonAirplane song "White Rabbit". Presumably they'll still work if you get them from Mom's Coin Purse/Mom's Bottle of Pills, though.
101* ''Afterbirth'' added an item called Black Powder which lets you draw circles of the eponymous substance to form pentagrams that deal damage to enemies standing in the area, with the description [[Music/PearlJam "Spin the black circle."]] (The song itself being about the singer's [[NewMediaAreEvil preference for vinyl records]].)
102* [[http://bindingofisaacrebirth.gamepedia.com/Spider_Mod Spider Mod]] is a reference to ''Spidermod'', an extensive GameMod for the original ''The Binding of Isaac''. Its creator, [=Spider853=], [[PromotedFanboy was a lead developer]] for ''Rebirth''.
103* The description for one of the new items in ''Afterbirth'', the Lil' Chest, reads ''"[[Film/{{Se7en}} What's in the box?]]"''
104* The Forget Me Now item is a reference to ''Series/ArrestedDevelopment''. On the show, Gob the magician gives people who figure out one of his tricks a "forget-me-now", which is a roofie.
105* My Shadow, one of the new items in ''Afterbirth'', has a description that says ''[[https://youtu.be/BPwM0YGMQaw "Me! And my shaaaaaaaaaadow!"]]''
106* The icon of one new item in ''Afterbirth'', Zodiac, is very similar to the symbol the [[https://en.wikipedia.org/wiki/Zodiac_Killer serial killer known as the Zodiac killer]] used to sign his taunting letters to the police and press.
107* There are 3 very hard to unlock items called The Body, The Mind, and The Soul. Their descriptions are respectively "I feel all", "I know all", and "I am all". They are a reference to the movie ''Film/{{Highlander}}'', as the three are said almost verbatim when [=MacLeod=] wins The Prize.
108* A new item in ''Afterbirth'' are the [[Music/NineInchNails 8 Inch Nails]].
109* Another new item in ''Afterbirth'' is the [[http://bindingofisaacrebirth.gamepedia.com/Ventricle_Razor Ventricle Razor]], which [[VideoGame/{{Portal}} lets you spawn blue and orange trapdoors that you can warp between.]]
110* From the wiki's page for [[http://bindingofisaacrebirth.gamepedia.com/GB_Bug GB Bug]]:
111-->''The pickup quote "Game breaking bug, right away!" is a reference to a quote by Phil Fish in ''[[Film/IndieGameTheMovie Indie Game: The Movie]], '' where he says the exact same words when a bug is discovered in FEZ on the first day it is being shown at PAX. This has been confirmed by Edmund himself on [[https://twitter.com/edmundmcmillen/status/666029976920043520 twitter]].''
112* The description of the Louse (a trinket) reads: "[[VideoGame/ResidentEvil Itchy. Tasty...]]"
113%%* The second phase of the boss [[spoiler:Mega Satan]] has a significant resemblance to the [[VideoGame/{{Doom}} Icon of Sin]].
114* One of the new achievements for ''Afterbirth+'' is titled [[VideoGame/FiveNightsAtFreddys Five Nights at Mom's.]]
115* You can get a potato peeler that permanently raises your damage and gives a meat cube for the entire run. The price? [[Theatre/TheMerchantOfVenice A pound of flesh.]] ''Repentance'' also adds an item literally named "A Pound of Flesh" that causes shop items to cost health instead of money and Devil deals to cost money instead of health.
116* One of the items introduced in ''Afterbirth+" looks exactly like the classic [[https://bindingofisaacrebirth.gamepedia.com/Butter_Bean Butter Bean]], but is actually a unique item called [[https://bindingofisaacrebirth.gamepedia.com/Wait_What%3F Wait What?]]. The flavor text for this item states that "[[https://en.wikipedia.org/wiki/I_Can%27t_Believe_It%27s_Not_Butter! I can't believe it's not Butter]] Bean!"
117* The "Endless Nameless" trinket is named after the HiddenTrack from Music/{{Nirvana}}'s ''Music/{{Nevermind|Album}}''. The description is [[VideoGame/TimeFcuk "I'm stuck in a loop..."]]
118* The first booster pack for ''Afterbirth+'' saw the addition of Bozo, an item that paints Isaac as a SadClown. This item is, of course, a reference to [[https://en.wikipedia.org/wiki/Bozo_the_Clown Bozo the Clown]], a popular TV character during the 60's and 70's.
119* A new item added in the second booster pack for ''Afterbirth+'' is Leprosy. Its tagline? "''[[Film/TheRoom2003 You're tearing me apart!]]''"
120* The Telekinesis item in Booster Pack #2 allows Isaac to hold enemy shots in place. The icon shows a hand with an open palm and the thumb tucked in, exactly like [[Film/TheMatrix Neo]].
121* Booster Pack #3 features a new angel room item in the form of a prism. Its pickup quote is "[[Music/PinkFloyd Eclipsed by the moon]]".
122* Booster Pack #3 also features a new shop item called Mr. ME!, which spawns a CaptainErsatz of a [[WesternAnimation/RickAndMorty Mr. Meeseeks]] to perform a task for the player. It's based in part on a workshop item that summons the genuine article.
123* Booster Pack #3 also added the Door Stop trinket. Its tagline is [[Series/GameOfThrones "Hold the door!"]]
124* One of the Steam Workshop items added in Booster Pack #5 (also known as The Forgotten update) is a familiar version of VideoGame/{{Spewer}}.
125* Booster Pack #5 locks certain bosses behind two achievements that require [[spoiler:defeating ??? with 3 and 6 characters]]. The achievements for completing this are called [[{{Theatre/Macbeth}} "Something wicked this way comes!"]] and "Something wicked this way comes+!", after the famous line from the Witches.
126* ''Repentance'' adds a spinning top item called Spin to Win. Its pickup quote is "[[Franchise/{{Beyblade}} Let it rip!]]".
127* ''Repentance'' allows you to input [=SVPE RH0T=] in the seed menu to unlock "VideoGame/SuperHot mode", which significantly slows down everything if Isaac isn't moving.
128* In ''Repentance'', you can kill the otherwise impervious boss Great Gideon with the Chaos card, which spawns a unique crawl space that contains two items, two chests, and a key. The crawl space is named Gideon's Grave in the game's code, referencing both the main antagonist of ''ComicBook/ScottPilgrim'' and his Chaos Theatre.
129* The Magic Skin item added in ''Repentance'' is a reference to ''The Wild Ass's Skin'' by Honoré de Balzac, a novel about a man who finds an enchanted piece of skin from a wild ass. In the story, the skin can grant wishes, but drains his life force as a consequence; in the game, using the skin will spawn an item from the current room's pool, but permanently reduces your maximum health by one with each use. Like the skin in the story, the Magic Skin will eventually reappear if you try to leave it behind.
130* In ''Repentance'', Delirum's Steven form was redesigned to heavily resemble Ash from ''VideoGame/TheEndIsNigh''. Also in ''Repentance'', Delirium's redrawn [[DemBones Death]] form features [[VideoGame/{{Undertale}} a single yellow "eye light" in its left eye socket]].
131* King Baby's description used to be "Lord of the dead". ''Repentance'' changed it to "[[Film/ArmyOfDarkness Hail to the]] [[{{Pun}} King Baby!]]".
132** Similarly, Freezer Baby has the pickup quote "[[Music/VanillaIce Iced Iced Baby]]".
133* Decap Attack, both in name and function, is a a shout-out to the UsefulNotes/SegaGenesis game of [[VideoGame/DecapAttack the same name]], which revolves around a character who throws his head to attack.

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