History Main / AcquiredPoisonImmunity

** Ash has gotten fried by Pikachu so many times that he's built up a near-total immunity to electric shocks, surviving jolts that were outright ''exploding'' whatever they hit in a later episode. Meowth also made use of his Pikachu-induced shockproofing once.
** Once or twice Team Rocket have shrugged off electric shocks simply because they've been hit by Pikachu so many times.

** Worgen have a racial ability, Aberration, which reduces the duration of curses and diseases they are afflicted with. Presumably, because they're already afflicted with the Worgen curse.

* In ''[[LightNovel/BOFURIIDontWantToGetHurtSoIllMaxOutMyDefense BOFURI: I Don't Want to Get Hurt, so I'll Max Out My Defense]]'', the main character Maple uses this to maximize her skill (via using potions when she's about to die) to develop a higher level of immunity and to have a chance to defeat a poison dragon.

* In Paizo's ''TabletopGame/{{Pathfinder}}'', the [[http://paizo.com/pathfinderRPG/prd/advanced/baseClasses/alchemist.html Alchemist class]] slowly gains resistance to poison over the first 9 levels of their career before finally becoming completely immune at level ten, presumably using this method.
* ''TabletopGame/SpiritOfTheCentury'' features an endurance stunt called Developed Immunities that makes a character flat-out immune to "common" poisons and gives +2 or +6 to rolls to resist uncommon ones, depending on whether or not the character has encountered them before. A character who combines this stunt with a sufficiently high Endurance trait has nothing to fear from any save perhaps the most outlandish poisons. (As they run on their own versions of the same system, the exact same stunt can also be found in ''TabletopGame/{{Starblazer Adventures}}'' and ''TabletopGame/LegendsOfAnglerre''. The also related but somewhat less pulp-ish ''TabletopGame/{{The Dresden Files}}'' omits it.)
* Classic ''TabletopGame/{{Traveller}}'' supplement ''SORAG: Handbook of Organization and Equipment''. During the {{PC}} creation process a SORAG agent can be assigned to the Medical Division. During the assignment, the agent can be given immunity to Truth Drug by injections of small doses of the drug over an extended period under carefully controlled conditions to build up the body's natural resistance. There is a small chance of the agent's body resisting the treatment, in which case no immunity is gained and the agent's Endurance drops by 1 point.
* In ''[[TabletopGame/{{Warhammer}} Warhammer Fantasy]]'', ogre butchers (wizards that eats all kinds of dangerous things to cast spells) have the immune to poison rule, so one would assume they have built up a very handy poison immunity.

* In a similar vein to the ''Pokemon'' example below, in ''Manga/FairyTail'', the heroes face an enemy that uses colored magical confetti to produce various elemental effects. When said enemy attempts to use yellow [[ShockAndAwe lightning-producing]] confetti on Mirajane, the latter laughs, as (having had Laxus for a guildmate during his entire [[JerkAss jerkass]] phase) she's been zapped enough times that the yellow confetti can't produce enough voltage to faze her.

* The Rough-Skinned Newt has enough tetrodotoxin to kill a room full of adult humans, as a result of a ridiculous [[LensmanArmsRace evolutionary arms race]] with Gardner snakes. The evidence suggests that each newt eaten adds more to the snake's overall resistance.

** In ''ComicBook/SpiderIsland'', Mary-Jane is one of the last people to be infected with Spider Flu. [[ComicBook/FantasticFour Reed Richards]] theorizes that the delay was due to her having [[GettingCrapPastTheRadar been with]] [[Franchise/SpiderMan Peter Parker]] for years.

* In "Literature/RappaccinisDaughter", the botanist Rappaccini tries to replicate an old legend about an assassination attempt against Julius Caesar by raising his daughter on poison so that her very nature is poisonous and a kiss could kill a man. Then a young man sees her and falls in love. Rappaccini wants them be a new (poisonous) Adam and Eve but the young man accepts a vial that should neutralize her poisons so they can be together as a normal couple. Despite her foreboding and asking the young man if he really wants her to take it. [[spoiler: After she drinks it she dies, as her nature was so full of poison she could not live without it.]]

* In Creator/NathanielHawthorne's short story "Rappaccini's Daughter" the alchemist Rappaccini tries to replicate an old legend about an assassination attempt against Julius Caesar by raising a young woman on poison so that her very nature was poisonous and a kiss could kill a man. He raises his daughter in a garden of poisonous plants. Then a young man sees her and falls in love. Rappaccini wants them be a new (poisonous) Adam and Eve but the young man accepts a vial that should neutralize her poisons so they can be together as a normal couple. Despite her foreboding and asking the young man if he really wants her to take it. [[spoiler: After she drinks it she dies, as her nature was so full of poison she could not live without it.]]

* Poisoning is the de facto assassination method of the Nyissans in the ''Literature/{{Belgariad}}''. So much so that any government official who lives for very long (case in point: Sadi) has not only long since acquired immunity to some poisons, but is trained to recognize much more, and doses himself with antidotes frequently, just in case. It's explicitly noted that the poisons taste much better than the antidotes.

* in ''Literature/TheHungerGames'' short story ''Fanfic/{{Secrets}}'', a companion piece to "Fanfic/TheVictorsProject" it's mentioned that using this trope was the only thing that kept Luster Lancaster( leader of District One's career victors in the authors previous fanfics) from being killed by one of his own victors (who was prostituted by Snow at Luster's suggestion) several times during the fifth decade of the games.

* The movie ''WesternAnimation/FindingNemo'' posits this as the reason clownfish can survive life among sea anemones -- Marlin insists on Nemo brushing himself against the tendrils each morning in the vein of a human parent telling a child to brush their teeth thoroughly. Scientific theories vary on whether this is TruthInTelevision or not.

* In ''ComicBook/TheBoys'' the Russian mob attempts to kill the team with poison but while most of them were knocked out but kept alive by the [[AppliedPhlebotinum Compound V]] in their system, Hughie and Love Sausage are completely unaffected due to them drinking Love Sausage's [[VodkaDrunkenski brake fluid cocktail]] which happened to build up their tolerance for poison.

* In ''ComicBook/TheBoys'' the Russian mob attempts to kill the team with poison but while most of the team were knocked out but kept alive by the [[AppliedPhlebotinum Compound V]] in their system, Hughie and Love Sausage are completely unaffected due to them drinking Love Sausage's [[VodkaDrunkenski brake fluid cocktail]] which happened to build up their tolerance for poison.

** Throughout the series, this is a racial trait of the [[LizardFolk Argonians]]. Living in the [[DeathWorld Black]] [[SwampsAreEvil Marsh]] with so many poisonous and toxic lifeforms has made the Argonians almost totally immune to natural and magical poisons. Likewise, the [[OurElvesAreBetter Bosmer (Wood Elves)]] and [[HumansAreWarriors Redguards]] typically have lesser (around 50%) natural racial resistances to poisons.

Here's a typical scenario: The hero has finally appeared at his confrontation with the BigBad, who's seated at his big table, just about to take his evening meal. "There's no reason to be uncivil," the villain says. Would the hero like some wine? The hero takes a drink and immediately starts choking. The villain laughs - that fool, the hero, should have known that the villain would poison the wine with the dreaded juice of the [[NamesToRunAwayFromReallyFast Ultramurder]] fruit!

* Implicitly in DC's ''Electric Warriors'', which is set somewhere in the post-apocalyptic world of ComicBook/{{Kamandi}} where humanity has somewhat recovered and is coexisting with uplifted animals. The Earth has settled into a galactic community that avoids war over scarce resources through a hunger games kind of ritual where they [[SuperEmpowering empower]] champions to battle on their civilization's behalf. The food stocks from Earth are stuff known to be highly toxic like [[ComicBook/Elongated man Gingold]] or the Joker's [[Recap/BatmanTheAnimatedSeriesE34TheLaughingFish laughing fish]].

* In ''The Orphan and the Jeweler'' (a companion story to ''VideoGame/{{Diablo III''}}), Stepfather Yao administers tea poisoned by a lethal plant known as scorpion root to Covetous Shen. After drinking the tea and remaining unharmed, Shen remarks that his immunity comes from a time when he was trapped on an island full of scorpion root and poisonous snakes and was forced to eat them to survive, thus granting him immunity to most poisons. As one might expect, Yao is properly baffled by this.
* In the ''WebVideo/SuperMarioLogan'' episode, "[[Franchise/{{Shrek}} Shrek's]] Diet", it is revealed that the diabetes Shrek got from eating nothing but [[TrademarkFavoriteFood cheesecake]] his entire life has caused his body to build up an immunity to diabetes.

* After extensive exposure to the powers of [[CastingAShadow darkness]], it's revealed in ''VideoGame/KingdomHeartsDreamDropDistance'' that Riku has become immune to the corruptive nature of darkness, [[spoiler:meaning Xehanort is unable to use him as a vessel any longer]].

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* ''Webcomic/EnsignSueMustDie'': Mary Sue built up an immunity to ''phaser blasts'' this way.
* [[InvokedTrope Invoked]] and then immediately [[SubvertedTrope subverted]] in this Webcomic/{{Exiern}} [[http://www.exiern.com/2012/05/03/pass-the-iocaine-powder-2/ page]]:
-->'''King Urtica:''' I trust I have a resistance to the poison in this wine. (''sips'')\\
'''Madam Amalia:''' Any poison I would use wouldn't give you the opportunity.
* ''Webcomic/LatchkeyKingdom'' has princess Rosaline Lannistark, though her parents were [[http://latchkeykingdom.smackjeeves.com/comics/2261667/minion-11/ a bit mean-spirited]] in teaching her.
* One (SFW) ''Webcomic/{{Oglaf}}'' comic has a very experienced food taster [[http://www.oglaf.com/naturalcauses boasting that he's immune to pretty much everything by now]] to his latest client, who then keels over after one bite of the meal he'd just tasted.
-->'''Food Taster:''' You won't be wanting that, then?
* ''Webcomic/RiversideExtras'': Subverted. [[FemmeFatale Ophelia]] does drug both drinks, foiling Simon's attempted PoisonedChaliceSwitcheroo, making a dramatic exit as Simon lies on the floor twitching...only to stumble and see double once she's left the room. She just had the advantage of anticipating the effects of the ether. Fortunately, the ether's effects are nonfatal for both of them.
* [[TokenWizard Isaac]] of ''Webcomic/ValAndIsaac'' has managed to achieve this by ''[[https://tredlocity.tumblr.com/post/180114719416 accident]]'' due to him drinking poison that his college [[TheEngineer Minow]] keeps putting next to his coffee.

* Sylvester, in ''Literature/{{Twig}}'', is the recipient of the Wyvern formula, which consists of a variety of natural toxins and poisons which is regularly ''injected into his brain'' in order to improve brain plasticity and healing, which grants him the ability to rapidly retrain himself in different skillsets. As a side effect, he's developed resistance to a variety of common poisons, though there's still more that can beat him.
* In the ''WebVideo/SuperMarioLogan'' episode, "[[Franchise/{{Shrek}} Shrek's]] Diet", it is revealed that the diabetes Shrek got from eating nothing but [[TrademarkFavoriteFood cheesecake]] his entire life has caused his body to build up an immunity to diabetes.
* A milder example, as it's not really a poison. In WebVideo/TheNostalgiaCritic's music video "F**king Love Christmas", Critic sings a psychotic metal song about how much he loves the holiday. He terrifies Malcolm and Tamara so much that Malcolm has to tranquilize him. He then sings that he built up an immunity to tranquilizers because of his insane love of Christmas.
* In ''Roleplay/FenQuest'', it's mentioned that immunity to [[{{Mutants}} Tomato]]'s deadly venom must be periodically "maintained" by ingesting some of it, otherwise, it wears off over time. When his sister [[ThemeNaming Cheese]] is accidentally stung after months apart, they determine she still has enough resistance to survive unaided, but will nonetheless get gravely ill without an antidote.

* In ''The Orphan and the Jeweler'' (a companion story to VideoGame/{{Diablo III}}), Stepfather Yao administers tea poisoned by a lethal plant known as scorpion root to Covetous Shen. After drinking the tea and remaining unharmed, Shen remarks that his immunity comes from a time when he was trapped on an island full of scorpion root and poisonous snakes and was forced to eat them to survive, thus granting him immunity to most poisons. As one might expect, Yao is properly baffled by this.

* Downplayed variant in ''WesternAnimation/SallyBollywood''. When everyone in school gets sick except for Sally, it turns out it was because the lunch that day used an extra strong pepper. Sally was the only one unaffected thanks to her heritage meaning that she was used to eating food that spicy, having eaten that same pepper her entire life.

* Similar to the SNL example above, in ''WesternAnimation/FamilyGuy'', Quagmire has also built up [[BlackComedyRape an immunity to mace]] after being pepper-sprayed so many times.
* In ''WesternAnimation/{{Metalocalypse}}'', Pickles is immune to the mind-erasing effects of Totally Awesome Sweet Alabama Liquid Snake, and every other drug as well, as the result of doing "government weed" daily since the age of 6.
* Similarily, but on a more technological level, Old Man [=McGucket=] from ''WesternAnimation/GravityFalls'' has a built-up immunity to the effects of the Mind-Wiper Gun due to using it on himself so much. PlayedWith in that the Mind-Wiper Gun doesn't have any effect on him because it has already done [[DisabilityImmunity all the damage]] [[InsanityImmunity it possibly could.]]

* In one segment of ''[[WesternAnimation/RockyAndBullwinkle Peabody and Sherman]]'', Mr. Peabody uses this trope to help the husband of Lucrezia Borgia.
* In ''WesternAnimation/YoungJustice'', Aqualad reveals that he is "largely immune" to the jellyfish toxin that Cheshire uses to coat her darts. Largely doesn't mean completely, though: he was weakened by it, more with each dose. Of course, this may be a result of his Atlantean biology and not an acquired trait.
* Dan from ''WesternAnimation/DanVs'' has been hit with tear gas and pepper spray so many times that he doesn't feel their effects anymore. He can even tell the differences.
* Nigel Thornberry claims in ''WesternAnimation/TheWildThornberrys'' that he's developed an immunity to poisonous plants by rubbing their juices all over his body.

* The titular ''WesternAnimation/{{Archer}}'' has been poisoned and drugged so many times in his line of work, he can metabolize and shake off toxins with ludicrous speed.

* In Creator/JohnWyndham's ''Literature/TheDayOfTheTriffids'', the narrator is only alive at the beginning because a career of working with Triffids has led to him building up enough resistance to survive the sting that put him in hospital. Simon Clark's sequel, ''Literature/TheNightOfTheTriffids'', develops the idea, with a way being discovered for people to deliberately cultivate an immunity, offering a way in which humanity can finally take the world back from the Triffids.
* One ''Literature/SixteenThirtyTwo'' short story centers around a poisoning that was originally suspected to be a murder until it was discovered to be an accidental suicide. The dead man had been dosing himself with arsenic regularly in an attempt to build up an immunity. Unfortunately, his regular supplier had been selling him adulterated drugs, so his immunity wasn't built up anywhere near as much as he thought. After buying a new supply from a different chemist, who sold him pure arsenic, he took what he thought was the appropriate dosage for his regimen, which was based on the weaker drugs of his first supplier. The massive dose of pure arsenic overpowered his limited immunity and killed him.
* In Nathaniel Hawthorne's short story "Rappaccini's Daughter" the alchemist Rappaccini tries to replicate an old legend about an assassination attempt against Julius Caesar by raising a young woman on poison so that her very nature was poisonous and a kiss could kill a man. He raises his daughter in a garden of poisonous plants. Then a young man sees her and falls in love. Rappaccini wants them be a new (poisonous) Adam and Eve but the young man accepts a vial that should neutralize her poisons so they can be together as a normal couple. Despite her foreboding and asking the young man if he really wants her to take it. [[spoiler: After she drinks it she dies, as her nature was so full of poison she could not live without it.]]
* In ''Literature/RiverOfTeeth'', [[MasterPoisoner Hero]] has acquired a poison immunity by taking small doses of poison with their iced tea each day, though it's never specified which poison in particular it is.
* In Literature/TheCulture novel ''Literature/{{Inversions}}'', a doctor called Vosill is called to treat a man being tortured, [[MercyKill only for him to die suddenly]]. Suspicious, the TortureTechnician insists that Vosill taste the medicine that she just gave the deceased, but it has no effect. Later when the doctor's assistant goes to taste the medicine out of curiosity Vosill quickly stops him, implying this trope. [[spoiler:It's strongly implied that Vosill is a [[AliensAmongUs Culture agent]], so would be immune to poisons and disease thanks to their advanced technology.]]
* ''Literature/JourneyToChaos'': Tiza states that her apprentice training included small doses of different poisons to develop an immunity. She refuses to say which ones because it is a secret but one of them comes in handy [[spoiler: when a trio of zombies try to kidnap her using chloroform.]]
* {{Downplayed|Trope}} in "Different Kinds of Darkness" by Creator/DavidLangford, wherein "basilisks" are printable images that [[BrownNote short out the human brain when viewed]]. A group of schoolchildren makes an endurance contest out of staring at a weak version they call "the Trembler", [[AchievementsInIgnorance unknowingly]] building up a resistance to the basilisk effect; when a truly deadly basilisk is left in the school, a member is able to destroy it and only passes out from the sight.
* ''Literature/ThreeDarkCrowns'': Thanks to her Arron training Katharine has this for a variety of poisons, but it has come at the cost of her health.
* In ''Literature/TheFolkOfTheAir'', Jude Duarte has been intentionally ingesting small amounts of the various Fae poisons in order to gain an immunity to there deadly effects over time. This backfires though as she eventually becomes addicted to these poisons.
* ''Literature/FateStrangeFake'': False Assassin mentions that she trained to be able to imitate Hassan of Serenity's technique Zabaniya: Delusional Poison Body, which turns her into a PoisonousPerson. Her training made her immune to many poisons.

* ''Series/TheTwilightZone1959'': In "[[Recap/TheTwilightZoneS5E149TheJeopardyRoom The Jeopardy Room]]", the Soviet commissar Vassiloff tricks the defector Major Ivan Kuchenko into drinking wine mixed with a sleep drug by drinking first. He built up an immunity to the drug by repeatedly taking increasing doses over time.
* In ''Series/TheVampireDiaries'' Katherine has built up an immunity to vervain, she can still get disabled by it if taken by surprise by a large enough dose but she gets over it much faster. Stefan uses this technique to get over his addiction to human blood.

* In a sketch in ''Series/HumanGiant'' a contestant practices for a literal gas guzzling contest (as in ''drinking'' gallons of petrol and yes it was shown to be as deadly as that sounds) by drinking various poisons including paint thinner to build up an immunity. [[spoiler:he wins but doesn't have a car.]]
* On ''Series/MyNameIsEarl'', Catalina has been given some tea spiked with sleeping pills by a vengeful "Crazy Witch Lady" (played by Creator/BettyWhite). She winds up in the woman's basement with Earl and company...but she ends up tying herself up, saying that because [[FridgeHorror her drinks have been spiked with so many date-rape drugs over the years]], she's developed a tolerance, but couldn't make a woman who reminded her of her aunt back home feel bad.
* In one episode of Series/{{NCIS}}, the victim turns out to have been a hitman and his murderer is one of his intended victims. He used snake venom, and the woman kept snakes and developed immunity, although she didn't specify whether this was her intention or just a side-effect of her preferred pets.
* In ''Series/OneThousandWaysToDie'', a man decided to pick up a spider and let it bite him to gain immunity to its venom. Naturally, since he had no idea what he was doing, the bite kills him.
* In the Halloween episode of ''Series/GameShakers'', "Scared Tripless, this was part of the prank Double G played on the kids, primarily his son. [[spoiler:Since the previous Halloween, he had been taking small amounts of venom so he can fake his death after being bitten by a snake.]] While it is successful, he forgets that [[spoiler:snake bites can become infected and the doctors have to give him a shot in his butt to prevent it.]]
* There was an episode of an old show (can't recall the name), where a child was bitten by a rare breed of a snake. It turned out that there was just enough anti-venom available for a single dose. Unfortunately, a doctor ends up accidentally also getting bitten by the same snake. She chooses to let the child have the anti-venom. Luckily, there's a hermit snake wrangler, who has developed an immunity to the same venom, and he eventually allows his blood to be drawn and distilled into an impromptu anti-venom for the doctor.

* An inadvertent version in ''Series/IClaudius''. The wife of a Roman official is drugging his wine so she can have an affair with Serjanus while he's asleep. Serjanus convinces her they have to MurderTheHypotenuse instead, as he'll eventually become resistant to the drug.

* In ''[[TabletopGame/{{Warhammer}} Warhammer Fantasy]]'', ogre butchers (wizards that eats all kinds of dangerous things to cast spells) have the immune to poison rule, so one would assume they have built up a very handy poison immunity.
* ''TabletopGame/SpiritOfTheCentury'' features an endurance stunt called Developed Immunities that makes a character flat-out immune to "common" poisons and gives +2 or +6 to rolls to resist uncommon ones, depending on whether or not the character has encountered them before. A character who combines this stunt with a sufficiently high Endurance trait has nothing to fear from any save perhaps the most outlandish poisons. (As they run on their own versions of the same system, the exact same stunt can also be found in ''TabletopGame/{{Starblazer Adventures}}'' and ''TabletopGame/LegendsOfAnglerre''. The also related but somewhat less pulp-ish ''TabletopGame/{{The Dresden Files}}'' omits it.)

* ''TabletopGame/HollowEarthExpedition'', supplement ''Mysteries of the Hollow Earth''. Cannibal tribes are known for their skill in creating poisons. Some of them include small doses of poison in their meals to build up an immunity to them.
* In ''TabletopGame/MiceAndMystics'', the first mouse to be captured with at least one poison wound will not receive poison wounds until the end of the chapter.

* Also spoofed in the NewspaperComic ''ComicStrip/CloseToHome'', where a golfer subjects himself to gradually stronger shocks of electricity to build immunity to lightning strikes.

* The titular badger in ''Fanfic/TheUrthbloodSaga'', among his other powers, has built up an immunity to all but the strongest poisons from this method. One poor ferret who tried to poison him and take over his army learned this the [[CruelAndUnusualDeath hard way...]]
* In ''[[Fanfic/{{Origins}} Origins]]'', a ''Franchise/MassEffect''[=/=]''Franchise/StarWars''[[spoiler:[=/=]''[=Borderlands=]''[=/=]''[=Halo=]'']] MassiveMultiplayerCrossover, Samantha Shepard has to ''turn this off'' in order to get drunk since she's now more [[Franchise/StarWars machine than woman]]. Mordin Solis even has to adjust the power in her cybernetic legs to let her dance!
* In ''Fanfic/RubyAndNora'' Oobleck thinks he has this trope. While one tranquilizer doesn’t knock him out, a heck of a lot more do.
* In ''WebVideo/YuYuHakushoAbridged'', it is implied that this is how Suzaku learned to control ''lightning''.

* in ''Literature/TheHungerGames'' short story ''Fanfic/{{Secrets}}'', a companion piece to "Fanfic/TheVictorsProject" it's mentioned that using this trope was the only thing that kept Luster Lancaster( leader of District One's career victors in the authors previous fanfics) from being killed by one of his own victors (who was prostituted by Snow at Luster's suggestion) several times during the fifth decade of the games.
* In ''WebVideo/UltraFastPony'', [[WeaksauceWeakness Rarity is allergic to water]]. In "Copywrong", she tries to build up immunity by soaking in a pool. Twilight points out that her allergic reaction seems to be getting worse, not better.
* In ''Fanfic/FateIngensCor'', Assassin picks up one of Archer's missed poisoned arrows and stabs herself. The poison weakens her a bit, but she quickly recovers and gloats that the poison will never affect her again.

* ''Film/ThePrincessBride'': The Man In Black challenges Vizzini to drink from two cups, one of which has been poisoned with iocaine. After they both drink [[spoiler:and Vizzini dies, the Man in Black reveals that he poisoned both cups because he'd spent the last ten years developing an immunity to iocaine]].
* ''Film/UnderSiege2DarkTerritory'' has a thug who has been pepper-sprayed so many times, all it does is clear out his sinuses. And then he proves it by using it as a breath freshener.

* In ''Film/ThankYouForSmoking'', terrorists [[spoiler:try to kill the main character by covering him in nicotine patches, which would overwhelm any normal person, and leaving him naked on the lap of the Lincoln Memorial]]. He survives and recovers fairly quickly because he'd been chain smoking for years and had built up a [[BlessedWithSuck superhuman tolerance to nicotine.]] Unfortunately (fortunately?) it also means [[CursedWithAwesome he can never smoke again.]]

* In ''Film/YourHighness'', The Wise Wizard, Fabious, and Thadeous smoke herbs together. The Wise Wizard and Fabious get stoned immediately and suffer hallucinations, but Thadeous (who regularly smokes pot) is unaffected.

* In the short film ''Film/TheBloodyOlive'', the female lead explains to a bystander that she was vaccinated against all types of poisons, which rendered the villain's poison dart ineffective.

* In Kim Newman's ''Literature/TheHoundOfTheDurbervilles'', in an international meeting of bad guys, Rupert of Hentzau passes around a flask that no one takes since nobody trusts the others. Even after Rupert openly takes a drink, Colonel Moran thinks to himself that he could have built up an immunity, and mentions that Madame Sara (another Victorian villain) who does take a drink, likely has made herself immune to all poisons.
* The Battle of Wits scene in William Goldman's ''Literature/ThePrincessBride''. The Man In Black has just tricked Vizzini into consuming poisoned wine, and reveals to Buttercup that the wine he'd consumed was also poisoned; [[OutGambitted he had developed immunity to the poison via this method]].
* The murderer in the Literature/LordPeterWimsey novel ''Strong Poison'' builds up an immunity to arsenic in this way. This does ''not'' work in RealLife... though the reference books Lord Peter reads really do exist, and they really did [[ScienceMarchesOn claim that it worked]].
* ''Literature/{{Discworld}}'':
** A novel or two mentions a food-taster who has ingested so many poisons that he's not only immune to them but can recognize them by taste (very handy). He can also tarnish silver by breathing on it (not so handy). He reputedly eats a toad a day to stay in practice.
** The [[OurVampiresAreDifferent vampires]] in ''Literature/CarpeJugulum'' have also built up a resistance to garlic, sunlight, holy water, [[BeatItByCompulsion vampiric OCD,]] and holy symbols by this method. [[spoiler:It backfires, sort of. When they lose the immunity, they realize they're surrounded by ''the shapes'' of holy symbols they wouldn't recognize if they hadn't been shown so many different ones becoming immune in the first place]].
** Played with in ''Mort''. The first King that Mort sees die asks Death how he was killed. Death explained it was by a crossbow. The king laughed and said "And here I have been making myself immune to all of these poisons. There's no immunity to cold steel, eh?"
* In ''Literature/TheCountOfMonteCristo'', old Monsieur Noirtier survives a murder attempt using poison because he has been taking a medicine that contains the same compound, and has built up a resistance to it. Realizing that his granddaughter and heir Valentine is also a target, he starts giving her small doses of his medicine; this saves her life when the poisoner has a go at her. The poisoner later tries again using a different poison, but by then Valentine's LoveInterest Maximilien has called in his friend the Count of Monte Cristo, who saves the day in his own inimitable style.
* Poisoning is the de facto assassination method of the Nyissans in the ''Literature/{{Belgariad}}''. So much so that any government official who lives for very long (case in point: Sadi) has not only long since acquired immunity to some poisons, but is trained to recognize much more, and doses himself with antidotes frequently, just in case. It's explicitly noted that the poisons taste much better than the antidotes.
* In the Creator/DashiellHammett [[Literature/TheContinentalOp Continental Op]] short story "Fly Paper" (1929) a woman wants to poison her abusive boyfriend but is afraid he'll be suspicious if she gives him something without drinking it herself. After reading ''Literature/TheCountOfMonteCristo'' she takes small doses of arsenic (extracted from flypaper) to build up an immunity, but instead fatally poisons herself. In discussing the case afterward the detectives reveal that the book is wrong; while some people have a natural resistance to arsenic, it's not possible to build up immunity through controlled exposure. The poison of choice in ''The Count of Monte Cristo'' is in fact [[http://en.wikipedia.org/wiki/Brucine Brucine]], and '''is''' subject to Mithridatism.

* The Creator/AEHousman poem "[[http://www.bartleby.com/123/62.html Terence, This Is Stupid Stuff"]]" retells the legend of Mithridates, a king who over the course of his life ate small doses of poison in his food to slowly build immunity to poisons and thus foil potential assassins. This story is used as an allegory; Housman's poem claims that the purpose of his poetry is to inoculate the reader against the evils of the world by describing them in palatable verse.
* Liz Williams' ''The Poison Master'' averts this: the Master Ari Ghairen modifies his own body with spider and snake genes to be both resistant and toxic, in an effort to keep up with the cold war in his Guild.
* The Dornish in ''Literature/ASongOfIceAndFire'' are rumoured to put extremely low doses of snake venom in their food along with all the spices, which may be an allusion to this trope. It's supposedly done more for the mild numbing, tingly effect and/or MachoMasochism (''a la'' fugu) than a conscious attempt to build up immunity, though... that is, if it's not just a lie they tell to outsiders.
* In Kalki's classic Tamil novel ''Sivakamiyin Sabadam'' (''Sivakami's Vow''), the villainous monk Naga Nandi builds up an immunity to cobra venom. It gets to the point that it runs through his veins instead of blood, and cobras come flocking to him, attracted by the scent.
* This is a plot point in Sharyn [=McCrumb's=] novel ''If I'd Killed Him When I Met Him''.
* Harnrim Starangh, a Red Wizard from ''[[Literature/TheElminsterSeries Elminster's Daughter]]''. "It had taken two years of retching weakness to build up a resistance to killing doses of staeradder", but being able to use a fast-acting poison freely was worth it since his most dangerous foes were other wizards whom he couldn't expect to quickly defeat by magic.
* In ''Literature/TheHungerGames'' [[spoiler:President Snow tried to build up a resistance to all of the poisons used to kill his opponents, but wasn't always successful, hence the smell of blood from the long-term injuries he's suffering from]].
* In ''The Journey of The Catechist" Etjole Ehomba can talk to animals, and a snake puts a very slight poison into his waterskin due to his politeness. He then shrugs off a poisoned dart after having built up an immunity. At which point the dart shooter decides to switch to much more effective magic, and kills Etjole outright.
* The ''Franchise/{{Disgaea}}'' [[LightNovel/DisgaeaNovels novels]] gives an explanation as to why [[Characters/DisgaeaHourOfDarkness Laharl]] survived being poisoned by [[Characters/DisgaeaHourOfDarkness Etna]] in the [[VideoGame/DisgaeaHourOfDarkness game]], the reason was that his crazy aunt [[Characters/DisgaeaNovels Yasurl]] gave him the same poison when he was little and in her care.

* In the ''Literature/GauntsGhosts'' novel ''Traitor General'' it is mentioned that the Nihtgane partisans have built up immunity to the poisons in the Untill fauna.
* Sam of ''Literature/VillainsByNecessity'' has developed one of these to every poison he's likely to encounter in his career as an assassin -- [[CantHoldHisLiquor except alcohol]]. He actually chides his EvilTwin for poisoning a knife with a toxin they are both immune to while they fight.
* ''Literature/MalusDarkblade'' develops dermal immunity to poison after years of smearing himself with venomous slime of the huge fearsome lizard he uses as a mount, which he'd been doing so that the beast would allow him near it.

* A plot point in Gary Jennings' Raptor, becoming something of a ChekhovsGun. The idea is that a ''person'' can become poisonous, by taking small amounts of poison, and kissing or sleeping with that person will poison his or her partner.
* Speaking of Jennings, in ''Literature/{{Aztec}}'', the travelers all take their snakebite prevention medicine, which involves being injected with venom from a tooth of each kind of poisonous snake. The doctor who performs the procedure advises Mixtli that his bite will now be venomous; when he finds out it's not, he assumes he is not immune to snakebite.
* In the ''Literature/{{Paradox}}'' novel ''Even the Wingless'' after almost being poisoned with hekkret, a recreational drug for the Chatcaava but a deadly poison to most Alliance races, Eldritch ambassador Lisinthir starts smoking small amounts of hekkret to build up an immunity. Unfortunately, he becomes addicted, and it doesn't provide total immunity against the daily attempts to poison him as he starts vomiting blood.
* ''Literature/PhoenixAndAshes'': The aftermath of his World War I experiences has Reggie taking ''lots'' of sedatives in order to sleep at night (enough that he's getting concerned). Alison isn't aware of this, so when she injects him with opiates to keep him prisoner the dosage isn't nearly enough to do the job.
* In the ''Literature/TalesOfTheFiveHundredKingdoms'' book ''The Snow Queen'', the Godmother Aleksia is using her MagicMirror to gather information on a tyrant that she will need to deal with. She notes that the tyrant visits his Alchemist daily for a concoction made of thirty common poisons, which gives him immunity to all but truly exotic poisons (and the reason why he doesn't need to employ a tester). For the truly exotic poisons (which are usually slow acting), the alchemist would have the antidote handy.
* In ''Literature/EmilyTheStrangeStrangerAndStranger'', Emily does this with the Black Jackal spider. Even so, the bite still partially paralyzes her.

* Killua from ''Manga/HunterXHunter'' is immune to virtually all forms of poison due to his family's TrainingFromHell, and is seen happily downing five cans of laxative-laced juice before the Hunter Exam starts.
* In ''Anime/NinjaScroll'', Kagero's body absorbs toxins instead of processing them. It makes her ideal for working as her master's food taster, but it's also made her bodily fluids highly toxic, which is good for assassination -- [[BlessedWithSuck not so much for potential love interests]]. [[spoiler:However, the kiss she and Jubei share just before she dies is implied to be enough to counteract the poison in his body.]]

* ''Manga/SaiunkokuMonogatari'':
** Ryuuki built up a resistance to various poisons mostly thanks to growing up as TheUnFavorite at the bottom of a pecking order of six princes and their mothers. He once realized that [[TamperingWithFoodAndDrink Shuurei had been handed a poisoned drink]] and drank it himself before she gulped it down, counting on the trope to work; it did and he lived to tell, but it still made him rather sick.
** Sa Sakujun in the same series built up a similar resistance through bored experimentation, not that it does him a lot of good in the end.
* Most of the Gourmet Hunters in ''Manga/{{Toriko}}'' have resistance to various poisons due to incidental or deliberate exposure. Coco is an extreme example, having been exposed to so many toxins that he's able to [[PoisonousPerson synthesize them within his body]], and on the rare occasion that he's hit with a poison that he ISN'T immune to, he can adjust his immune system within seconds.

* Subverted in ''Manga/{{Bleach}}''. During Mayuri's fight with Szyael, as his bankai's poisonous gases seep over to the injured Uryu and Renji, Uryu initially believes that unlike Renji, he will be safe from the poison, as he was poisoned before in his previous battle with Mayuri. Uryu then shows symptoms of poisoning, and Mayuri mocks the idea that someone could become immune to his poison, saying that it is constantly adapting itself.
* In ''Manga/{{Dokuhime}}'' little girls are purchased for the purpose of bringing them up to be Poison Princesses and exposed from the time they're in their cradles to poison in order to build up immunity. Many don't make it, the successes are trained to be assassins whose very touch is deadly. They have to keep ingesting poison to function properly.
* In ''Manga/AkumaNoRiddle'', Haru Ichinose has gone through so many surgeries that she has started to become resistant to sleep-inducing drugs. Even if she does get affected, she wakes up a lot faster than a regular person would.
* In ''[[LightNovel/BOFURIIDontWantToGetHurtSoIllMaxOutMyDefense BOFURI: I Don't Want to Get Hurt, so I'll Max Out My Defense]]'', the main character Maple uses this to maximize her skill (via using potions when she's about to die) to develop a higher level of immunity and to have a chance to defeat a poison dragon.
* In a similar vein to the ''Pokemon'' example above, in ''Manga/FairyTail'', the heroes face an enemy that uses colored magical confetti to produce various elemental effects. When said enemy attempts to use yellow [[ShockAndAwe lightning-producing]] confetti on Mirajane, the latter laughs, as (having had Laxus for a guildmate during his entire [[JerkAss jerkass]] phase) she's been zapped enough times that the yellow confetti can't produce enough voltage to faze her.
* In ''Manga/Brave10'', this is a common part of ninja training as demonstrated by Anastasia, Saizo and Sasuke during the Goemon gang's KnockoutGas attack. They aren't immune to every kind of poison and even the ones they are cause them to become weak the longer their exposure is, but the three proper {{ninja}} of the team are all able to keep fighting even when the rest of the team is completely out because ninja are CrazyPrepared.
* In a later chapter of ''Manga/{{Onidere}}'', it's revealed that Tadashi has been rendered completely immune to all forms of poison due to constantly eating [[LethalChef his girlfriend's cooking]].
* Downplayed in ''Anime/LittleWitchAcademia2017''. For Akko, [[ComedicSociopathy getting repeatedly poisoned]] by [[TokenEvilTeammate Sucy]] finally pays off when it allows her to briefly resist the bites of a couple of venomous snakes [[spoiler:controlled by [[EvilAunt Lady Daryl Cavendish]]]], but she soon collapses and requires urgent medical attention.
* ''Manga/HolyCorpseRising'': Amala's parents died and her older brother abused her and kept her prisoner, feeding her poisoned food in an attempt to kill her. Determined to survive, she ate the food little by little, eventually developed an immunity to the poison, and grew strong enough to kill her brother. In the present, [[MasterPoisoner Mylitta's]] poisons only affect her for about a minute.
* In ''Manga/MissionYozakuraFamily'', the titular spy family doses their meals with poison on a regular basis to build up an immunity as part of their TrainingFromHell. It proves essential when facing enemies with poisoned weapons in the field and saves Taiyo's life on several occasions (at least after getting over the [[PottyFailure initial bouts of diarrhea]]).

* Spoofed in ''WesternAnimation/TheTick'', with a minor character [[ItRunsOnNonsenseoleum who claims to have been building up an immunity to bullets this way.]] The character was an expy of ComicStrip/DickTracy, who has been shot an absurd number of times over the decades.
* Also spoofed in the NewspaperComic ''CloseToHome'', where a golfer subjects himself to gradually stronger shocks of electricity to build immunity to lightning strikes.

* [[{{Ninja}} Chizu]] in ''ComicBook/UsagiYojimbo'' takes a small dose of poison every day for this reason.
* ComicBook/{{Wolverine}} has assassin Reiko invoke this trope with blowfish toxin, which Jubilee learns while dodging attacks.

* ComicBook/SpiderMan seems to be developing an immunity to the gas used by the Green Goblin to nullify his Spider-Sense. Originally, the stuff rendered him unconscious and would make him unable to use the power for several days. Most recently, when the Hobgoblin used it in the "Revenge of the Sinister Six" story, he was able to stay conscious and recover in little over ''one'' day.
* In ''ComicBook/SpiderIsland'', Mary-Jane is one of the last people to be infected with Spider Flu. [[ComicBook/FantasticFour Reed Richards]] theorizes that the delay was due to her having [[GettingCrapPastTheRadar been with]] [[Franchise/SpiderMan Peter Parker]] for years.
* ComicBook/{{Venom}}'s symbiote has been stated to have become increasingly resilient to flames and sonics through repeated exposure. How much more resilient it's become depends on the writer.
* In the comic ''New X-Men'', Laurie Collins aka Wallflower is the daughter of Sean Garrison, a mutant with extremely powerful pheromone production and control, who had Laurie's mother Gail in his thrall until Laurie was conceived. Because Laurie inherited her father's mutation, carrying her made her mother immune to Sean's pheromones and enabled her to break free of his control.
* ''ComicBook/BlackMoonChronicles'': The master of the ThievesGuild that Pilou grew up in kept the other criminals in line by putting poison in their food and providing an anti-toxin at the end of every day if they had fulfilled their quota. Pilou starts to take a small portion of the poison every day to build up an immunity so he can one day escape.
* ''ComicBook/RedRobin'''s opponents the [[MurderInc Council o]][[HuntingTheMostDangerousGame f Spiders]] have a couple of poison users who are [[RequiredSecondaryPowers immune]] to their own poisons.
* ComicBook/{{Blade}} once fought with [[HeroKiller Draconis]], a [[SinisterMinister vampire priest]] that developed immunity to all traditional weaknesses like holy symbols and sunlight with small gradual exposures to it, in addition to his unshakable faith turning him into a "[[ReligiousVampire Holy Vampire]]".

* Downplayed in ''Anime/LittleWitchAcademia''. For Akko, [[ComedicSociopathy getting repeatedly poisoned]] by [[TokenEvilTeammate Sucy]] finally pays off when it allows her to briefly resist the bites of a couple of venomous snakes [[spoiler:controlled by [[EvilAunt Lady Daryl Cavendish]]]], but she soon collapses and requires urgent medical attention.