History MadScientist / VideoGames

* ''AdvanceWars'' had Lash, a girl genius version of the mad scientist. The reboot ''Days of Ruin'' has Caulder/Stolos, probably the most extreme mad scientist ever. Among his creations are [[spoiler:the games equivalent to nukes, a giant bomber, cloned humans intended to be used as [[SuperSoldier Super Commanders]], and most of all, a virus that kills its host by growing flowers all over its body]]. He also loves to manipulate people into fighting each other just so he can observe them and views humans as little more than test subjects... [[CloningBlues Including himself]].
** He [[spoiler: doesn't think that the flower virus is deadly enough, so he UPGRADES it to kill EVERYONE (rather than just children, which is what the first version did).]] Also, [[spoiler: 'Giant Bomber' means a plane so large that two armies can fight on one wing, and each bomb can destroy thirteen buildings in one explosion.]] Guy is a genius. Completely insane nutcase, but still a genius.

** Relmyna from [[VideoGame/TheElderScrollsIVOblivion Oblivion]]'' expansion ''Shivering Isles'' stands out. Obsessed with the power of flesh (no, really), she enjoys creating twisted monstrosities such as Flesh Atronarchs and the Gatekeeper, and considers them her "children". She also conducts some grisly experiments on the concepts of pain and suffering. Oh, and [[SociopathicHero she's on your side]].

* ''Franchise/TheElderScrolls'' has several, but Relmyna of ''Shivering Isles'' stands out in particular. Obsessed with the power of flesh (no, really), she enjoys creating twisted monstrosities such as Flesh Atronarchs and the Gatekeeper, and considers them her "children". She also conducts some grisly experiments on the concepts of pain and suffering. Oh, and [[SociopathicHero she's on your side]].

** Surely Bowser can count. He's mad all the time. Not crazy mad, angry mad, but still... And who do you think designs and builds all his mechanical toys?

* ManaKhemia gives us Jess, a [[RoseHairedGirl Rose-Haired]] GenkiGirl who loves to experiment with alchemical bombs and medicines. And by "medicines", we mean "potions that magnify cavity pain and/or turn people green." The fact that her experiments tend to [[EpicFail blow up in her face]] might actually be a good thing.

** Warwick was a "mercenary alchemist" until he was transformed into a werewolf as an [[{{Unishment}} attempted punishment]]. He really likes being a werewolf, but hasn't made a lot of scientific contributions since, presumably because he's too busy tearing people apart.

** Heimerdinger wants to create a weapon powerful enough to prevent war. As a result of an experiment his [[MyBrainIsBig head has expanded to make room for more brain]]. Unlike most of those listed he's highly respected as an inventor and his creations are used by others.

* [[spoiler: [[TheMole Dr. Pettrovich Madnar]] ]] is revealed to be this in ''VideoGame/MetalGear2SolidSnake''.

* ''VideoGame/{{Thief}} II: The Metal Age'' features Father Karras of the Mechanists. He's mentioned in the first game as the fellow responsible for Garrett's replacement ocular, but by the second installment, he's gone completely 'round the bend and is cheerfully intent on bringing about TheEndOfTheWorldAsWeKnowIt. Among his achievements are the successful invention of robots, cameras, voice recordings, and motion-sensing automatic cannons in a vaguely Medieval SteamPunk setting, along with horrific cyborgs that [[FateWorseThanDeath constantly weep in agony and beg for death]]. He also has a preoccupation with Garrett...

* Mao in ''VideoGame/{{Disgaea}} 3''. Despite being the main character, Mao is quite possibly the archetypal mad scientist. Thoughts of experimentation on interesting subjects send him into an excited fit, even if the subject turns out to be himself. The main story ends with [[spoiler:Mao capturing and continually experimenting on the BigBad, instead of killing him.]]
** ''[[VideoGame/Disgaea4APromiseUnforgotten Disgaea 4]]'' introduced the Professor class. One of her personality types is even called "Mad Scientist".

* The ''{{Pokemon}}'' games usually have a few scientists willingly working for the main villains.

* Dr. F of ''MySims Kingdom'', who enthused after a successful experiment that "History will replace the word 'science' with the name 'F'!"

* Daniel Dankovski, Bachelor of Medicine from {{Pathologic}} is an InUniverse subversion of this trope. He is thanatologist, pursuing the purpose of [[EnemiesWithDeath defeating death]] by researching pocesses of dying and necrosis. He is infamous for revolutionary ideas and experiments that seem insane and immoral. So he was called in press, his labaratory is closed and he is persecuted by society and government. In fact, though he is a bit eccentric, he is a decent guy, completely sane, just pretty sarcastic.

** He [[spoiler: doesn't think that the flower virus is deadly enough, so he UPGRADES it to kill EVERYONE (rather than just adults, which is what the first version did).]] Also, [[spoiler: 'Giant Bomber' means a plane so large that two armies can fight on one wing, and each bomb can destroy thirteen buildings in one explosion.]] Guy is a genius. Completely insane nutcase, but still a genius.

*** Played straight and then subverted by [[spoiler: Dr. Morbius, who plays the stereotypical mad scientist bent on domination and revenge with [[ForScience science]] but it then turns out *he* is the responsible one (sort of) who's role is to keep the other scientists who are actually far worse than him in check.]]

** A better example is Daro'Xen; a quarian who believes the geth should be put back under the control of the quarians, regardless of how much HeelFaceBrainwashing it takes. In fact... especially if it involves that. She casually mentions that she [[TheyWouldCutYouUp performed surgery]] on her toys [[CreepyChild as a kid]], and [[WhatMeasureIsANonHuman the geth are no different]]. Tali calls her insane to her face right after. She's appropriately voiced by ClaudiaBlack.

* ''{{Thief}} II: The Metal Age'' features Father Karras of the Mechanists. He's mentioned in the first game as the fellow responsible for Garrett's replacement ocular, but by the second installment, he's gone completely 'round the bend and is cheerfully intent on bringing about TheEndOfTheWorldAsWeKnowIt. Among his achievements are the successful invention of robots, cameras, voice recordings, and motion-sensing automatic cannons in a vaguely Medieval SteamPunk setting, along with horrific cyborgs that [[FateWorseThanDeath constantly weep in agony and beg for death]]. He also has a preoccupation with Garrett...

* ''VideoGame/MassEffect2''s Mordin Solus may qualify, although he's more eccentric than outright mad. He's a Salarian doctor who was formerly a member of a special forces squad, then ran a clinic where he cured a population of a devastating plague while personally shooting attacking mercenaries in the head, both of which he sees as a public service. He also seems to have a taste for Gilbert & Sullivan.
** He also keeps up a set of ethics and principles that he refuses to break, notably despising the idea of PlayingWithSyringes and experiments that lead to more suffering than necessary. In the end, he believes in saving lives, even through [[IDidWhatIHadToDo questionable]] [[WellIntentionedExtremist means]].
** A better example is Daro'Xen; a Quarian who believes the Geth should be put back under the control of the Quarians, regardless of how much HeelFaceBrainwashing it takes. In fact... especially if it involves those. She casually mentions that she [[TheyWouldCutYouUp performed surgery]] on her toys [[CreepyChild as a kid]], and [[WhatMeasureIsANonHuman the Geth are no different]]. Tali calls her insane to her face right after.
*** Daro'Xen is appropriately voiced by ClaudiaBlack.

** Henry Lawson! Ohh boy, Henry Lawson. First he creates DesignerBabies to continue he legacy and [[OffingTheOffspring disposes of them]] whenever they don't meet his standards. And then there's Sanctuary which he advertised as a safe haven during the Reaper War and lured thousands of war refugees and families. Once they got there, they were experimented on and turned into husks and indoctrinated soldiers for Cerberus.

->"I even cured walking...Then, I invented Globotron, [[DisproportionateRetribution which would destroy anyone FOUND walking]]."

** We also have Dr. Weil from the ''[[VideoGame/MegaManZero Zero]]'' series, [[spoiler:Master Albert]] from the ''VideoGame/MegaManZX'' series, as well as Wily and [[spoiler: Regal]] from the ''BattleNetwork'' series, and Vega and [[spoiler:King]] from the ''[[VideoGame/MegaManStarForce Star Force]]'' series. In fact, it seems most Mega Man villains are mad scientists. [[FridgeLogic How else would they get all those robots, if not building them]]?