History MadScientist / VideoGames

* ''VideoGame/{{Fallout}}''
** The Master from ''VideoGame/{{Fallout|1}}'', who beneath a calm, arrogant exterior topped by the reasoning of a WellIntentionedExtremist exhibited a multiple personality disorder and overall emotional frailty.
** ''VideoGame/{{Fallout 3}}'' had Dr. Stanislaus Braun, a Vault-Tec scientist who created an advanced simulation program that he subjected the population of Vault 112 to, torturing and killing them in different ways and bringing them back with the technology at his hands.

* The BigBad of ''VideoGame/SecretAgent'' and the head of [=DVS=] [[note]]DiabolicalVillainSociety[[/note]] is Dr. No Body, a BrainInAJar in a robot body, who stole the plans for a powerful space laser and seeks to rebuild it to threaten the world.

** For the expansions, Dr. Oggurobb (a Hutt science genius) qualifies, referring to his experiments as "[[TrueArtIsIncomprehensible art]]" and casually suggesting that you find a Force-sensitive to [[ImAHumanitarian feed a Dashade]] you free from stasis in an optional quest.

* ''VideoGame/DeadSpace'' has two, one [[TheProfessor good]], the other...[[KnightTemplar not]] [[BigBad so]] [[EvilutionaryBiologist much]].
** The first one, Terrance Kyne, while he's gone a bit batty after being thrust into the middle of a ZombieApocalypse, and has a habit of talking to his [[DeadPersonConversation late wife]] ([[spoiler:although that's not a sign of mental illness, it's a manifestation of the Marker]]), he's an OK sort who just wants to help Issac.
** The other is {{M|adDoctor}}ercer, who will do [[MoralEventHorizon absolutely nothing]] to endear you to him.
** Nolan Stross from ''VideoGame/DeadSpace2'' was also a scientist. In the prequel movie ''Aftermath'' [[spoiler:he is exposed to a shard of the Marker and incidentally causes most of the crew of his ship, the ''O'Bannon'', to get killed by Necromorphs. He also murders his wife and infant son in a fit of hallucinations.]] He's institutionalized on the Sprawl, [[spoiler:and links up with Isaac and Ellie; at first he's somewhat lucid and wants to destroy the marker, but as the game goes on, his hallucinations worsen, and becomes violent, gouging Ellie's eye out. He later tries to murder Isaac, who kills him in self-defense]].

* Any and ''every'' scientist working for Umbrella in the ''Franchise/ResidentEvil'' series is virtually guaranteed to be a Mad Scientist. The majority of the games in the franchise have also had a batshit insane researcher as the BigBad, including [[VideoGame/ResidentEvil Albert Wesker]], [[VideoGame/ResidentEvil2 William Birkin]], [[VideoGame/ResidentEvilCodeVeronica Alexia Ashford]], [[VideoGame/ResidentEvil0 James Marcus]], [[VideoGame/ResidentEvil5 Wesker, again]], and [[VideoGame/ResidentEvilOperationRaccoonCity Four-Eyes]].
** Overall series? Besides Wesker, we also have Spencer, who was originally a scientist who worked on the Progenitor Virus.

-->'''Hanpan:''' There you go again, with another crazy idea... Isn't this illegal?\\

* ''VideoGame/AdvanceWars'' had Lash, a girl genius version of the mad scientist. The reboot ''Days of Ruin'' has Caulder/Stolos, completely insane nutcase, but still a genius.

* ''VideoGame/TheNewOrderLastDaysOfEurope'' has Magnitogorsk led by Trofim Lysenko as a nation ruled by those. A group of talented but otherwise insane scientists, Lysenko and his fellow biologists make any sacrifices to defeat their enemies, including performing all kinds of abuse and torture on their people under the guise of "experiments" for the sake of their dubious theories in hopes that under extreme duress the tortured people will become super soldiers that are capable to defeat the Russian warlords and Nazi German invaders. In the mod proper, Magnitogorsk starts with the "Mad Scientist" spirit, which improves their defenses and gives boosts to research time, but decreases their manpower.

* ''VideoGame/{{Plants Vs Zombies}}'' has Dr. Zomboss, BigBad of the series. Also, BigGood Crazy Dave is implied to be one.

* In ''VideoGame/BlazBlue'', there's a heroic example in {{Jerkass}} CatGirl Professor Kokonoe, and a villainous one in one of the [[BigBadDuumvirate main villains]], the local MarionetteMaster and [[AbusiveParents abusive parent]] Relius Clover.

* ''VideoGame/SonicTheHedgehog'':

* ''VideoGame/StarFox'': Andross, who employed several bio-weapons (as in, lifeforms created as weapons) in VideoGame/StarFox ''64'' and ''Command''. The later however somewhat redeems his actions by revealing that [[spoiler: he had been working on a device that would terraform the aptly named planet Venom into a more inhabitable one. Which just happens to be the perfect counter to the new threat, which come from the acidic oceans of the planet]]. However, the same game also hints that he was the one who created the new threat in the first place in the Good Bye Fox scenario.

* [[spoiler: [[TheMole Dr. Pettrovich Madnar]]]] is revealed to be this in ''VideoGame/MetalGear2SolidSnake''.
* In ''VideoGame/MonsterLab'', the player is an apprentice Mad Scientist.

* ''VideoGame/FiveNightsAtFreddys'': The SerialKiller William Afton (the "Purple Guy") is revealed to pretty much be one over the course of the series. It's firmly established in ''VideoGame/FreddyFazbearsPizzeriaSimulator'', where he [[spoiler:is revealed to have been killing the kids to experiment with what's called "remnant", akin to the soul after death. He tried to find a way to allow souls to continue on in robotic bodies]], which shines light on his [[JokerImmunity seeming inability to die]].

* ''VideoGame/{{BioShock|1}}'': Dr. Suchong is the sinister and detached version, the warped genius behind much ADAM research, including several plasmids, the [[CreepyChild Little Sisters]], and the Big Daddies. He was the linchpin behind virtually everything that went wrong in Rapture, including [[spoiler:the protagonist himself]] -- but, at least, he [[spoiler:died an [[HoistByHisOwnPetard ironic death]]...]]

* In the first ''VideoGame/{{Borderlands}}'' DLC, Dr. Ned is a mad scientist played for laughs.
** Dr. Zed might not have a doctorate but he certainly qualifies. A short quest line in the sequel involves him creating two hybrid critters, the Skrakks (Skag/Rakk) and the Spycho (spiderant/Psycho).

* ''VideoGame/CallOfDutyBlackOps'' had three: Dragovich, Kravchenko, and Steiner.
** Clarke, who not only worked on Nova 6, but gave CrazyPrepared [[ExaggeratedTrope a whole new meaning]].

* The ''VideoGame/{{Helltaker}}'' DLC, Examtaker, is focused around a HalfHumanHybrid ungoing testing from the new demonic ruler of Hell, Loremaster. [[spoiler:This is the logical conclusion to [[FallenAngel Azazel's]] transformation into a demon, where her curiosity transformed her desire for research into an amoral seeker of new knowledge ForScience]]
* [[HerrDoktor Dr. Ort-Meyer]] from the ''Franchise/{{Hitman}}'' series, responsible for the protagonist's creation. With a reputation as a disgruntled, megalomaniacal geneticist (even pulling an extensive TheyCalledMeMad speech in the first game's finale), he was capable of creating a mindlessly loyal and equally lethal version of 47 over the course of the game, which nonetheless ended up being destroyed by 47 (although there survived a more primitive version which went on to serve as a minor antagonist in ''[[VideoGame/Hitman2SilentAssassin Silent Assassin]]''). The backstory of ''[[VideoGame/HitmanBloodMoney Blood Money]]'' deals with the impact of his creation's legacy and the prospect of it falling into the wrong hands.

* [[HerrDoktor Dr. Ort-Meyer]] from the ''VideoGame/{{Hitman}}'' series, responsible for the protagonist's creation. With a reputation as a disgruntled, megalomaniacal geneticist (even pulling an extensive TheyCalledMeMad speech in the first game's finale), he was capable of creating a mindlessly loyal and equally lethal version of 47 over the course of the game, which nonetheless ended up being destroyed by 47 (although there survived a more primitive version which went on to serve as a minor antagonist in ''[[VideoGame/Hitman2SilentAssassin Silent Assassin]]''). The backstory of ''[[VideoGame/HitmanBloodMoney Blood Money]]'' deals with the impact of his creation's legacy and the prospect of it falling into the wrong hands.

* ''VideoGame/PokemonXAndY'': [[BigBad Lysandre]] was a brilliant scientist whose earlier attempts to fix the world legitimately, through the inventions and profits of Lysandre Labs, didn't have the effect he was looking for -- where he expected the needy to be sated, they instead yearned for still more. [[MaddenIntoMisanthropy His two main conclusions]]: (1) World aggregate happiness is effectively finite; after a certain amount of beings, happiness and survival can only be attained by taking it from/denying it to another. (2) [[MisanthropeSupreme The vast majority of humans]] (and maybe even Pokémon, if his musings about Mega Evolution are anything to go by) are irredeemable, incapable of anything beyond the most narrow selfishness. [[ANaziByAnyOtherName Therefore]], the only way the world will ''ever'' know beauty and hope everlasting is to [[FinalSolution expunge all those imperfect creatures]] who ought never have existed, who can only ever ''be'' plagues on existence. As his report in Lysandre Labs puts it, "[[OverpopulationCrisis either everything is lost, or only a handful are saved]]". After being defeated he has a VillainousBreakdown, screaming that the player's "condemned the world to a future of misery and death" and attempts a TakingYouWithMe.

* The ''VideoGame/{{Portal}}'' series gives us Aperture Laboratories, a company full of mad scientists. Driven by their grandiosely insane founder and CEO, Cave Johnson, they got started in TheFifties by recruiting the best of the best of humankind and employing them as human lab rats in a vast array of MadScience experiments. Said experiments involved such things as BodyHorror transmutations, [[ILoveNuclearPower irradiation]], [[GeneticEngineeringIsTheNewNuke DNA injections]], and their signature ThinkingUpPortals device, one result of which was the Handheld Portal Device that forms a core part of the gameplay. Their crowning achievement was ArtificialIntelligence, but even here they only succeeded in creating an AI as madly deranged as they were. [=GLaDOS=] proceeded to [[TurnedAgainstTheirMasters take over the research program]]... by [[MurderIsTheBestSolution murdering all the scientists]] with a deadly neurotoxin. It is then up to the protagonist to enter this maze of insanity and [[EscapeFromTheCrazyPlace find a way to escape]]. The closing song to the first game (sung by [=GLaDOS=]) makes all this starkly clear.

*** Most infamously there was his [[SarcasmMode brilliant]] plan to breed [[WhiteMagicianGirl Aerith]] and [[IntellectualAnimal Red XIII]] together.