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9* ''Series/BuffyTheVampireSlayer'': Vampires are humans who have been turned into soul-less demons. Some of them, like Series/{{Angel}} and later Spike, are able to regain their soul, but others are quite better off dusted. Also, restoring the soul doesn't reset a vampire to the person they were as a human. It just makes them capable of feeling empathy and guilt for what they'd done in the meantime.
10* Parodied in ''Series/{{Community}}'' with Troy and Abed's cyborg hero Kickpuncher.
11-->"The only thing beyond the reach of my fists...is humanity."
12* ''Series/DoctorWho'':
13** Daleks:
14*** The original Daleks started off as the Kaleds of Skaro, [[HumanAliens who looked like humans]] [[HumanOutsideAlienInside (on the outside, at least)]], but started mutating into tentacle blob things due to a generations-long nuclear war. Then the chief Kaled scientist Davros realized this, and decided to speed up the process, removing a few little details like "empathy" or "pity" while he was at it.
15*** Another Dalek faction, the Imperials, were made from [[HumanPopsicle Human Popsicles]]. "Not pure enough in their blobbiness" indeed.
16*** [[Recap/DoctorWhoS27E13ThePartingOfTheWays One iteration]] of the Daleks were produced by "filleting, sifting, and pulping" living humans to render a handful of cells judged strong enough to be shaped into Dalek form and welded into a travel machine.
17*** [[Recap/DoctorWhoS33E1AsylumOfTheDaleks "Asylum of the Daleks"]]: [[spoiler:Oswin Oswald. The insane Daleks in the Asylum turned her into one of them supposedly due to valuing her intelligence, and she was unable to deal with it, instead dreaming that she was still human.]]
18** Cybermen:
19*** The Cybermen, more than any of the others. It's arguably the whole conception behind the way they were originally written in the 1960s.
20*** [[Recap/DoctorWhoS28E6TheAgeOfSteel "The Age of Steel"]]: In the new series, Cybermen all look identical and have the same voice, so it's particularly jarring when Pete Tyler is confronted by a Cyberman that used to be [[spoiler:his ''wife''.]]
21** Many stories involving TheVirus: e.g., [[Recap/DoctorWhoS3E2MissionToTheUnknown "Mission to the Unknown"]], [[Recap/DoctorWhoS7E4Inferno "Inferno"]], and [[Recap/DoctorWhoS13E6TheSeedsOfDoom "The Seeds of Doom"]].
22** Poor little Jamie from [[Recap/DoctorWhoS27E9TheEmptyChild "The Empty Child"]]/[[Recap/DoctorWhoS27E10TheDoctorDances "The Doctor Dances"]].
23** [[Recap/DoctorWhoS28E2ToothAndClaw "Tooth and Claw"]]: The werewolf's host was a boy who lived near the monastery. The monks abducted him as a child, and the wolf "ate his soul and sat in his heart". [[AndIMustScream And yet there's still a little of the human host left...]]
24** [[Recap/DoctorWhoS29E11Utopia "Utopia"]]/[[Recap/DoctorWhoS29E12TheSoundOfDrums "The Sound of Drums"]]/[[Recap/DoctorWhoS29E13LastOfTheTimeLords "Last of the Time Lords"]]: The Toclafane are AxCrazy flying metal spheres that are able to deploy knives and laserguns. [[spoiler:Turns out that they once were humans living at the time of the universe's end. They turned themselves into metal spheres in hopes of surviving the end of the universe.]]
25** The Face of Boe may have once been [[spoiler:Jack Harkness, or maybe Jack was just messing with the Doctor and Martha when he said that.]]
26** The Gunslinger in "[[Recap/DoctorWhoS33E3ATownCalledMercy A Town Called Mercy]]" Was Once A {{Human Alien|s}}. It's shown that he underwent implicitly non-consensual cyborgification in the prequel.
27-->'''Gunslinger:''' [[PreMortemOneLiner Make peace with your gods]].\
28'''Kahler-Mas:''' They used to be your gods ''too''.\
29'''Gunslinger:''' Not any more.
30* Pretty much the whole cast of ''Series/DoomPatrol2019'' but particularly former race car driver Cliff Steele who, after an accident, the only thing they were able to save was his brain and lives out his days as a robot.
31* ''Series/{{From}}'': It is heavily implied that the creatures that stalk the villagers were once humans. The "Pas de Deux" episode reveals [[spoiler: that the monsters have human anatomy when, but with all liquid dried up in inside.]]
32* ''Series/GameOfThrones'':
33** The "Oathkeeper" episode reveals that [[spoiler:a good number of the White Walkers were originally Craster's sacrificed sons whom the Night's King transformed with a touch.]]
34** The White Walkers attempted to turn Benjen Stark into a wight, but he was saved by the Children, who restored his mind. However, his appearance and the way their magic works makes it clear he isn't strictly human anymore either way.
35** [[spoiler:The Night's King was a man before the Children of the Forest turned him into the first White Walker.]]
36* ''Series/HeatVisionAndJack'': The CoolBike Heat Vision used to be Jack's friend Owen, before he got hit with an experimental ray gun that caused him to merge with his motorcycle.
37* ''Series/TheLordOfTheRingsTheRingsOfPower'': In the " Udun" episode is revealed that [[spoiler:all of the Orcs we see in the show were originally Elves of Beleriand, enslaved and twisted by Morgoth into Orcs.]]
38* ''Series/{{Lost}}'': [[spoiler: The Man in Black]] claims to have once been a human before becoming [[spoiler: a sentient cloud of smoke.]] He's now human again, only able to switch between his monster form and [[spoiler: John Locke.]] A flashback episode shows that this is true.
39* ''Series/OnceUponATime'': The Wicked Witch's flying monkeys.
40** ''Series/OnceUponATimeInWonderland'': The Grendel became a cannibal monster under the Red Queen's curse after he stole her Forget-Me-Knot. Also, all genies are revealed to have once been regular people.
41* ''Series/TheOrville'': At the start of the third season, the ''Orville'' goes to a new area of space where they come in contact with alien microbes that transform whatever being they come in contact with into spider-like aliens. This happens to at least a few dozen of the crew, and is treated as a DeathOfPersonality, seeing as how their bodies are still alive, but their minds have been completely erased.
42* ''Franchise/PowerRangers'':
43** In ''Series/PowerRangersTimeForce'', Frax, the robot who worked for Ransik but would eventually go solo, was once a human named Dr. Fericks who saved Ransik's life in the past, but was rewarded with the destruction of his lab and body. After using his own technology to rebuild himself, Frax vowed revenge on Ransik, and infiltrated his organization to bring him down from within.
44** Master Org in ''Series/PowerRangersWildForce'' was a Doctor before taking on the powers and identity of the original Master Org. His minions weren't happy when they found out, but he proved to be too much for them when they tried to rebel.
45** Zeltrax was transformed into a cyborg after a lab explosion. He is ''not happy'' about the loss of his body, and has decided that it is (in a roundabout manner) Tommy's fault. Mesogog was once a human scientist too.
46** In ''Series/PowerRangersSamurai,'' Deker and Dayu were once human. Dayu sold her soul to save the life of the then-human Deker, but Deker has lost his memory and is now a BloodKnight who fights to satisfy his bloodlust, either by defeating a WorthyOpponent or by being put out of his misery. [[spoiler: Last time he fought the Red Ranger, it looks as if the latter has finally happened. However, the season's only half over...]]
47* ''Series/{{Primeval}}'': Several people are infected by mutant mushrooms from the future, and two of them turn into [[MushroomMan mushroom monsters]].
48* ''Series/SleepyHollow'':
49** In "[[Recap/SleepyHollowS2E14KaliYuga Kali Yuga]]", Carmilla used to be human until she was captured by a cult and transformed into a Vetala. She later turns her henchmen into Vetalas and attempts to do the same to Hawley.
50** In "[[Recap/SleepyHollowS3E02WhispersInTheDark Whispers in the Dark]]", the whispering wraith is actually Marcus Collins, a turncoat soldier.
51* ''Franchise/StarTrek'': All Borg started as other species, usually humanoid. Seven of Nine, in particular, is an actual human from the Federation.
52* ''Series/{{Supernatural}}'': Several of the monsters are transformed humans.
53** The most important being the demons, all of which are formerly-human souls which turn into monstrous dark spirits after being tortured, corrupted and "mangled beyond human recognition"; usually in the bowels of {{Hell}}.
54** Others include some of the monsters created by [[MonsterProgenitor Eve]] such as vampires, werewolves
55** The title monster species in "[[Recap/SupernaturalS01E02Wendigo Wendigo]]" are what humans who've committed cannibalism and eaten enough human flesh transform into over the years. Likewise, the kohonta in "[[Recap/SupernaturalS14E16DontGoInTheWoods Don't Go Into the Woods]]" was created when a settler ate his family during a rough winter and was cursed by shamans with everlasting hunger.
56* ''Series/ThatMitchellAndWebbLook:'' The Quiz Broadcast sketches have '''Them''', deep-voiced, red-eyed zombie-like things who want to get inside (they ''really'' want to get inside), and are implied to know more about what caused the mysterious "Event" than anyone else. But they were once human, something that breaks the game-show host's StepfordSmiler routine briefly.
57-->'''Host:''' Why do They look like us?\
58'''Peter:''' Because they used to be us, didn't they?\
59'''Host:''' Yes, that's right. They used to be... us.
60* ''Series/{{Torchwood}}'': In "[[Recap/TorchwoodS1E5SmallWorlds Small Worlds]]", Jack reveals that each and every one of the monstrous Faeries was originally a child, all from different time periods, who became a Chosen One like Jasmine.
61* ''Franchise/UltraSeries'':
62** In Episode 23 of the original ''Series/{{Ultraman}}'', the MonsterOfTheWeek is Jamila -- an astronaut who was stranded on an alien planet without any water, only to be abandoned by his people back home. Mutated by the environment, the astronaut evolved into a monster and eventually rebuilt his rocket to travel back to Earth, which he sought to attack in revenge for its people leaving him out in the cosmos to die. Serious TearJerker ensues as our heroes are extremely reluctant to kill the mutant human, but are forced by their superiors to treat him [[WhatMeasureIsANonHuman as just another mindless kaiju]].
63** Jamila is later homaged by ''Series/UltramanGaia'' with a monster named Tsuchikera. He was originally Kondo, a biological warfare researcher during UsefulNotes/WorldWarII whom the Imperial Army mutated with a serum he developed to create super-soldiers when he refused to use it for the war. He fled to the swamps driven half-mad by his transformation but his friend Hirano remained by his side to help keep him sane. Unfortunately, radioactive leakage from underground nuclear testing begins to scramble Tsuchikera's brain and turns him into a giant monster. The results are an even sadder than Jamila's episode.
64** In ''Series/UltramanEighty'', the monster Lavuras used to be a human; specifically, Chief Itou, the second-in-command of the UGM, who was abducted by the slave-master monster, Gymaira, having drained Itou of his humanity and turning him into a monster. Gymaira did this to at least another victim as well, since the episode features a second monster slave, the octopus-kaiju Daron. Towards the end of the episode, Lavuras ultimately regains his humanity as Chief Itou long enough to assist Ultraman Eighty in battling Gymaira.
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