These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Harsher in Hindsight: With Robin Williams' death so soon after the show's run, it's quite painful to remember all those jokes about Simon's worry that he won't live to see any grandkids Sidney might give him.
Andrew’s sisters circumcised him themselves when the doctor who was supposed to do it didn’t arrive. Fortunately, they apparently ‘did a fantastic job’, but the kind of recklessness they display is horrifying.
Also, Andrew’s sister Elaine is a serial rapist who rapes men while they’re too drunk to know it happened the next day, and no-one seems to care.
Too Good to Last: One season and done. Though given the death of Robin Williams before a second season would have started, it was probably for the best.