- Alternative Character Interpretation: Gordon Rennie in one of his monthly rant columns in the Judge Dredd Megazine speculated that there is much Ho Yay between Johnny and Wulf. Naturally, this has resulted in much backlash and even prompted John Wagner to specifically write a scene where Wulf gets laid just to debunk this. He also speculated that Johnny was a drug addict who was imagining his powers.
- Complete Monster: Nelson Bunker Kreelman is a staunch anti-mutant politician in New Britain. Starting a Nazi-esque movement of "Kreelers", he institutes various anti-mutant policies to force them into ghettos and refugee camps in the bombed-out wastelands to slowly starve. When his son Johnny Alpha is born with a mutation and fearing that this might hurt his political career, he frequently abuses his son before trying to lock him up forever. The rebel mutant army succeeds in capturing most of the government, but Kreelman tells them to go ahead and kill the hostages anyway, figuring he can rule the country alone. Meanwhile he has 100 mutants executed every hour until the rebels surrender. Finding out that Johnny is among the captured mutant generals, he eagerly orders his execution. Kreelman then begins the construction of death camps to destroy the entire mutant population of New Britain, but is forced to resign by the prime minister when they realize he's gone too far and becomes a fugitive. He resurfaces years later to get revenge on Johnny, secretly taking over the Search/Destroy agency to frame Johnny and his allies, and later personally overseeing his son's slow death by torture.
- Crowning Moment of Awesome: There's certainly a good handful of these, especially when Max Bubba finally gets what's coming to him for killing Wulf.
Max Bubba: Why, Alpha—Why are you doin' this to me? Why are you torturin' me this way?Johnny: Because I hate you. [GUNSHOT]
- I Am Not Shazam: The main character is called Johnny Alpha. Strontium Dog is a derogatory term for a Search/Destroy agent.
- Iron Woobie: Johnny is a rare example of a manly character who still manages to fall under this trope. Whether it's the sheer amount of crap that gets piled onto him, or the way he stoically accepts the abuse and soldiers on; if you don't occasionally feel the urge to buy the poor man a beer and pat him on the back, you have no heart.
- Recycled In Space: Basically X-Men set in space.
- Replacement Scrappy: Feral falls squarely into this in the Spinoff Strontium Dogs; he wasn't necessarily seen as a bad or hated character, but since he was filling in for the lead after Johnny Alpha had died, he had very big shoes to fill.
- The Scrappy: The Gronk.
- Some Anvils Need to Be Dropped: Early strips were pretty heavy-handed with the anti-mutant racism. It's easy to forget that these were written when the Apartheid regime in South Africa still existed.