These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
YMMV: Dead Space
Anti-Climax Boss: The Hive Mind boss fight is pathetic, even on Hard mode. The only way you could possibly lose is if you're low on health, or low on ammo (or if you just piss it away during the fight). But it's kinda hard to be low on either one given that the floor is covered with ammo crates... not to mention that right before the fight, you can stock up on ammo or health at the store.
Broken Base: Get a large group of Dead Space players together in one room, and then immediately ask them whether or not this is one of the scariest horror games ever created. We'll wait.
Word of God admitted that the series is a love letter to the sci-fi and sci-fi horror genres in general.
Complacent Gaming Syndrome: Many people consider the Plasma Cutter the best weapon by far, and therefore play the game using only it. The fact that there is an achievement for doing this doesn't help. Using only one weapon also makes the game much easier, since you only get ammo drops for weapons you have equipped. If you only have one weapon equipped, then all of the ammo that drops will be for it. You'll get so much you'll be able to sell most of it without worry and spend the money on something useful.
Crosses the Line Twice: The Lurkers are actually dead babies that the necromorphs have had no qualms with assimilating into their ranks. Think zombie babies are bad? Wait until you see the grapple kill Isaac uses against the Lurkers, which involves him throwing it to the floor and punting it across the room.
Germans Love David Hasselhoff: Japan has a rather unusual affection to the Dead Space series. If you ever go into the FPS side of Japan (which is a niche market there), you will occasionally see references to it, even in many other FPSs as well. The fact that there are complete wikis dedicated to translating the entire series from English to Japanese despite not having an official translation there at all should tell you something.
Goddamn Bats: Swarmers are mostly annoying... unless encountered with other stronger Necromorphs.
Good Bad Bugs: When fighting a Brute, run down some stairs. They will turn and walk away from you. At which point you can unleash hell on them. Same happens if they're confronted by a narrow doorway, even though they have been shown to be able to completely demolish doors when the situation requires them to.
And let's just say that Necromorphs are really bad about opening doors (i.e. they can't). While this will have limited application in most cases, you can use it to gradually wear them down while they remain unable to retaliate.
Harsher in Hindsight: Anyone who read Dead Space: Martyr will likely cringe anytime the phrase "Altman Be Praised" is uttered since that book reveals that Altman was trying to stop the Marker's destructive influence and prevent it from being used as a weapon but he was eventually brutally murdered by corrupt Earth government officials who proceeded to twist the events of his death into making him the martyr of their new religion centered on the Markers, the very opposite of what he was trying to achieve.
Hell Is That Noise: The Divider give off a deep, unsettling groan as you get approach one.
Hype Backlash: There are many people, critics and regular players alike, who don't consider this game to be very frightening at all, despite the thousands of people who label it as the scariest game ever.
Iron Woobie: You'll really want to give Isaac a hug after his ordeal is over.
The entire scene with Kendra's killing of Kyne and revealing that she's The Mole.
Nightmare Retardant: The Hive Mind. All of the previous enemies, like the ones detailed above, kept you on your toes and your gun pointed up and into the shadows of the Ishimura's bowels just in case they try something. With the Hive Mind just there when you fight it, it's not as scary.
Fridge Logic: Instead of only preventing Isaac from running outside of a somewhat generous circular area but otherwise only occasionally attacking, why doesn't the Hive Mind just swipe its tentacles madly at Isaac as it did to Kendra?
At any rate, the Nightmare Fuel is restored if you simply look at the chunk of Aegis VII that's free-falling just above where you fight the Hive Mind.
Paranoia Fuel: You will DREAD going into a room full of corpses... Not because of what killed them, mind you but because the corpses themselves might try to off you.
You may develop an extreme phobia of ventilation shafts from this game as well.
Screw that - where did all that inert biomass growing all over the walls, floors, and ceilings come from? Ordinary dust, which is made up of dead skin that has flaked off. Bet you want to dust every single surface in your house now, don't you?
After one of the first Necromorph encounters, you may find yourself somewhat wary of elevators.
The Hunter, AKA: that damn regenerating Necromorph. Similar to the SA-X from Metroid Fusion, although it lacks the magnificently tense scripted scenes. Still, just knowing it's around somewhere in the ship is quite freaky.
Peril Rollover: "Great, you fixed the engines so we won't crash. Now you have to go and shoot down all the asteroids that are about to smash us to pieces. After that there's this giant monster in hydroponics that's screwing up our oxygen..."
Run Like Hell follows a character in deep space, separated from his girlfriend, who's trained in medicine. The station has been attacked by a previously unknown alien race, which has massacred basically everybody. The main character's lady sometimes sends him messages to show that she's okay.
The enemies, too, are quite similar. There are "Cutters", with scythe-blades for arms. There are "Brutes", who are huge, heavily-muscled berserkers who can resist massive gunfire. There are "Scouts", creatures with a scorpion tail. There are "Scout Sprites", breakaway enemies that serve as suicide bombers. There are "Elites", who can take human heads and put them atop their own bodies. And there is "Biomass", which converts the environment into an area appropriate for the aliens.
That One Boss: the giant space slug boss at the end of chapter eight involves using the most infuriating turret system ever to defeat. You start with 100% shields. One hit from a projectile knocks 10% of your shields down. The projectiles all move far, far faster than you can turn the gun. The kicker? One of the secret achievements for the game is to defeat the boss with over 50% of the turret's shields remaining. Uh, no.
This is hardly an issue with the PC version, which has the option to customize your aiming sensitivity. One wonders why the dev team didn't give console gamers a similar option, especially since most modern console shooters do.
That One Achievement: That achievement may be hard, but the achievement for doing the same thing when shooting the asteroids bombarding the ship is a huge pain in the ass, especially since in that case you don't start with 100% shields.