An expedition in Antarctica discovers ruins of a structure built by aliens. Inside, the explorers are attacked by those aliens and find carvings illustrating part of their history: they came to the Earth in ancient times and used a non-sapient, genetically engineered species for their own purposes. That species eventually (almost) obliterated them. In the climax, the protagonist flees out of the structure, chased by a creature from that non-sapient species.
What am I describing? Alien vs. Predator
or At the Mountains of Madness
The AVP movies and games are canon and are set in the same universe with both franchises
Okay, this might be odd for many but the very existence of Charles Bishop Weyland
in the first AVP movie is a big give away as we see the many Bishops in the future as found in the two movies and two games. Bishop (341-B) of the second movie, Karl Bishop Weyland of the third AVP game, Michael Bishop Weyland of the third film and the Bishop in the Aliens: Colonial Marines
video game. The OWLF sprung up again in the second movie which would bring us back to the second Predator film that showed a xenomorph skull in the Yautja trophy room.