A list of actors and actresses appearing in works based on the fiction of Arthur C. Clarke.
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Live-Action Films
2001: A Space Odyssey
- Keir Dullea: David Bowman
- Gary Lockwood: Dr. Frank Poole
2010: The Year We Make Contact
- Bob Balaban: Dr. Chandra
- Elya Baskin: Maksim Brajilovsky
- Candice Bergen: SAL 9000
- Dana Elcar: Dimitri Moisevitch
- Taliesin Jaffe: Christopher Floyd
- John Lithgow: Walter Curnow
- James McEachin: Victor Milson
- Helen Mirren: Tanya Kirbuk
- Roy Scheider: Dr. Heywood Floyd
Live-Action Television
Childhood's End
- Charles Dance: Karellen
- Georgina Haig: Annabel Stormgren
- Osy Ikhile: Milo Rodericks
- Julian McMahon: Dr. Rupert Boyce
- Colm Meaney: Hugo Wainwright
- Benedict Samuel: Fence
- Mike Vogel: Ricky Stormgren
- Ashley Zukerman: Jake Greggson