- Hey, It's That Guy!: His starring role in Wiseguy meant that Ken Wahl was no longer described merely as a "Sylvester Stallone look-alike". Kevin Spacey (who played Mel Profitt) would go on to Hollywood fame in the thriller Se7en. Steven Bauer played Tony Montana's ill-fated sidekick, Manolo Ribera, in Scarface (1983). Former comedian Jerry Lewis takes on a serious role as rag trade businessman Eli Sternberg, while other guest stars included Annette Benning, Stanley Tucci, Robert Davi, Joan Severance, Ron Silver, Tim Curry, Michael Chiklis, Chazz Palminteri, David Strathairn, and politician/actor Fred Thompson as Racist Villain Knox Pooley.
- Rearrange the Song: The Mike Post theme was given a Latin upgrade in Season 4.