- Acting for Two: Rodger Bumpass plays both Toxie and Dr. Killemoff, and Hal Rayle voices both Bonehead and Dr. Bender (the right half of Headbanger).
- Follow the Leader: For the 2023 game, it's not hard to think that it's following the lead of Teenage Mutant Ninja Turtles: Shredder's Revenge. Not that anyone's complaining.
- He Also Did: Jon Lock, the 2023 game's writer, was previously responsible for working on titles like Afterlife Inc and Spectacular Sparky.
- Recycled: The Series: The cartoon replaced all the R-rated elements with jokes and ridiculousness. Despite this, the series actually kinda works.
- Self-Adaptation: Unlike the older licensed games, Lloyd Kaufman and Troma were directly involved with supervising the development of Retroware's game.
- Sequel Gap: The 2023 video game, which is advertised as a sequel to the cartoon, came 32 years after the last episode aired in 1991.
- Sequel in Another Medium: According to the 2023 game's writer Jon Lock, it's a sequel for the original cartoon. Xander Arnot, the art director, noted in an interview that it essentially acts as a "Season 2".
- Show Accuracy/Toy Accuracy: The toyline is far more grosser and grizzlier in design than the characters' show designs.
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