Creator Breakdown: Writer Bob Budiansky suffered from stress due to trying to constantly shove in new toys, which led to him leaving the comic. He has since said that he has no intention of working on Transformers again, though that doesn't mean he wouldn't say "no" if Hasbro asked him. His only post-Marvel Transformers work was IDW's faithful adaptation of the animated movie, which was less stress-inducing for obvious reasons.
Sequel Gap: After 21 years the comic is finally getting a proper, epic conclusion with Regeneration One.
ShinjiAramaki also did several character designsnote Soundwave, his Cassettes and Reflector, to be specific. and created Perceptor.
Two that pertain to the movie: Several of the animators, prior or after, were employees of (among others) Studio DEEN, Madhouse and Studio Pierrot. Whereas Unicron was designed by Hiroyuki Hataike and Takehiko Ito, two men who would go on to help create Outlaw Star.
Jossed: Fanon assumed that the character Dion from the episode "War Dawn" survived the attack on storage yard 67 and was rebuilt into someone important (Ultra Magnus being the most popular choice), seeing as his best friend, Orion Pax was rebuilt as Optimus Prime. In 2010, Hasbro flat out stated that Dion was never rebuilt into anybody else and had not even survived. Also, The Transformers: Wings of Honor continuity had Dion survive the attack, but he was still called Dion.
The Other Darrin: Several characters went through this; most noticeably with series voice director Wally Burr, who voiced Ratchet (Masquerade), Thundercracker (War Dawn) and Jazz (Kremzeek) in different episodes when their normal actors (Don Messick, John Stephenson and Scatman Crothers respectively) were unavailable, and it showed. Onslaught also switched from S. Marc Jordan to Steve Bulen by "The Rebirth".
In "War Dawn," Ariel was supposed to die along with Dion. However, members of production realized that since she was Orion Pax's Love Interest, she could simply be rebuilt as Elita One. (This, by the way, is why fans propose Dion was also rebuilt into someone Optimus would know.)
Octane's role in "Starscream's Ghost" was originally intended for Blitzwing, who was banished from the Decepticons in the "Five Faces of Darkness" five-parter. Blitzwing was replaced by Octane to promote Octane's newer toy.