Director John Leonetti's budding directorial career was appropriately annihilated by Mortal Kombat: Annihilation; almost all of his work for the next 16 years (outside of The Butterfly Effect 2) was back in his usual job as cinematographer, before he made a second, somewhat more successful transition to director in the mid-2010s.
For producer Lawrence Kasanoff, which was a double flawless with the protracted production of his animated film Foodfight!; that movie's failure killed his cinematic career.
Dawson Casting: Inverted; while Sindel is supposed to be Kitana's mother, Musetta Vander is only four years older than Talisa Soto, and looks to be about the same age as her on-screen. To be fair, Sindel didn't really look that old in Mortal Kombat 3 either, but this film makes it even worse.
Fan Nickname: Get into any discussion of Mileena online and see how long it takes someone to refer to her as You Wish.
Franchise Killer: There were plans for a third movie, but disappointing box office returns saw them sent on a one-way trip to the Netherrealm. Years later, there were serious talks of a new movie, that may or may not have been a true sequel, but production difficulties led to it being scrapped.
Done with several of the main characters. The only actors from the first film to return for the second were Robin Shou (Liu Kang) and Talisa Soto (Kitana).
Aside from the main cast, only one actor from the first film returned for the sequel, namely, stunt double Keith Cooke. Here, however, he plays Kuai Liang, a.k.a. the younger of the Sub-Zero brothers; in the first film, he was Reptile's humanoid ninja form.