Creator Killer: Director John Leonetti's career outside of cinematography was appropriately annihilated by Mortal Kombat: Annihilation; he wouldn't direct again until 2006 and only directed two more movies since.
The film also performed a Fatality on the career of producer Lawrence Kasanoff, which was a double flawless with the protracted production of his animated film Foodfight!; that movie's failure impaled his cinematic career period.
Fan Nickname: Get into any discussion of Mileena online and see how long it takes someone to refer to her as You Wish.
Franchise Killer: There were plans for a third movie follow up, but disappointing box office returns saw them sent on a one-way trip to the NetherRealm. Years later, there were serious talks of a new movie, that may or may not have been a true sequel, but production difficulties led to it being scrapped.
The Other Darrin: Done with several of the main characters. The only actors from the first film to return for the second were Robin Shou (Liu Kang) and Talisa Soto (Kitana).
Aside from the main cast, only one actor from the first film returned for sequel, namely, stunt double Keith Cooke. Here, however, he plays Kuai Liang, a.k.a. the younger of the Sub-Zero brothers; in the first film, he was Reptile's humanoid ninja form.