Director John Leonetti's budding directorial career was appropriately annihilated by Mortal Kombat: Annihilation; almost all of his work for the next 16 years (outside of The Butterfly Effect 2) was back in his usual job as cinematographer, before he made a second, somewhat more successful transition to director in the mid-2010s.
The film also performed a Fatality on the career of producer Lawrence Kasanoff, which was a double flawless with the protracted production of his animated film Foodfight!; that movie's failure impaled his cinematic career period.
Dueling Movies: With another dark fantasy film from New Line, Spawn, and another martial arts movie from New Line, Rush Hour. It lost to both, but Spawn also earned some hard knocks from critics.
Fan Nickname: Get into any discussion of Mileena online and see how long it takes someone to refer to her as You Wish.
Franchise Killer: There were plans for a third movie follow up, but disappointing box office returns saw them sent on a one-way trip to the NetherRealm. Years later, there were serious talks of a new movie, that may or may not have been a true sequel, but production difficulties led to it being scrapped.
The Other Darrin: Done with several of the main characters. The only actors from the first film to return for the second were Robin Shou (Liu Kang) and Talisa Soto (Kitana).
Aside from the main cast, only one actor from the first film returned for sequel, namely, stunt double Keith Cooke. Here, however, he plays Kuai Liang, a.k.a. the younger of the Sub-Zero brothers; in the first film, he was Reptile's humanoid ninja form.
Just like in the first movie, Michael Jai White was slated to portray Jax. Ultimately, he turned down the role, this time to do Spawn (which unfortunately didn't fare any better with critics not named Roger Ebert than MKA did). He finally portrayed Jax in Mortal Kombat: Rebirth and Mortal Kombat: Legacy.
Christopher Lambert decided against reprising his role as Raiden to appear in Beowulf (1999) instead.
Linden Ashby was asked to reprise his role as Johnny Cage, but backed down because he was unceremoniously killed off five minutes into the movie.