- The Cast Showoff: Natalie slicing open a bottle of wine, which Cameron Diaz can do in real life.
- Creator Backlash: Jackass star Chris Pontius, who makes a cameo, admitted that he hates this film.
- Executive Meddling: The original script revealed the main villain's identity from the start, but the studio forced them to rewrite it into a surprise reveal like in the first film. And then they openly spoiled it in the trailers anyway.
- Fake Irish: Justin Theroux (Seamus) is American.
- Fake Mixed Race: This movie makes Alex an example as her father is played by John Cleese (white English) while Lucy Liu is Chinese-American.
- Franchise Killer: A third and fourth installment was initially planned to go into production, but after the box office disappointment of this film, Sony cancelled plans for any further sequels before a soft reboot with a new cast was released in 2019.
- Incidental Multilingual Wordplay: In English, the orphanage's mother superior describes their relation with the Thin Man as "the odd haircut now and then", allowing the French dub to use the amazing pun "une coupe de cheveux plutôt décoiffante", that is, literally "a fairly hair-messing haircut" (décoiffant usually meaning "exciting").
- Real-Life Relative: Luke Wilson's brother Andrew makes a brief appearance as a police officer.
- Refitted for Sequel: The first film was meant to have the original Angels make cameo appearances. That didn't pan out, but Jaclyn Smith appears here.
- Remake Cameo: Jaclyn Smith reprises her television role as Kelly Garrett.
- Scully Box: For the "U Can't Touch This" dance scene, Drew Barrymore (who is 5-ft-4) and Lucy Liu (who is 5-ft-3) wore heels in order to fit in the same frame as 5-ft-9 Cameron Diaz, who is barefoot.
- What Could Have Been:
- Jamie Foxx was originally in talks to play the new Bosley. Will Smith was also considered.
- Courtney Love was offered the role of Madison Lee, but turned it down. Joan Cusack was also considered.
- Tyler Hoechlin auditioned for the part of Max.
- Working Title: Halo.
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