It's no secret that the Big Show has acromegaly, the same condition that André the Giant suffered from. This is the reason for The Big Show's huge size. Unlike André, however, he actually got treated for it.
Show is still embarrassed about WCW booking him as "André the Giant's son" in his early matches there to the extent that, to this day, he still gets eager fans telling him how much they loved... his dad.
His run as a whole in WCW is this, as he hated the negative work environment as well as the constant back-and-forth backstage politics that made it difficult for him to work a match properly. Since he left for the WWF, he's been very vocal about his disgust working in WCW, even noting at one point that, despite being WCW Champion for a year, he was being paid less than Hulk Hogan and other veteran talents who defected from WWF.
Show looks back negatively on his run in WWE's ECW brand despite the fact that he's the only wrestler to hold the WWE Championship, the WCW Championship, and the ECW Championshipnote Show noted in WWE Untold that he never wanted the ECW Championship to begin with, as he knew the ECW fanbase would disapprove of someone who had never wrestled in ECW at all holding the belt. He's especially embarrassed by his match against Batista at the Hammerstein Ballroom in New York, as he had to deal with the fans booing and heckling throughout the whole match.
Dyeing for Your Art: From 1995 to mid-1996, his hair was permed, likely in order to look more like André the Giant.
Promoted Fanboy: Show was a huge Professional Wrestling fan in his youth. His favorite wrestler was Arn Anderson. He stated that he would like Anderson to induct him into the Hall of Fame someday.