Federico is voiced by Elias Toufexis, who was also Adam Jensen.
In a rare in-series example, the voice of the Damascus Bureau rafiq in AC1 returns as the voice of Leonardo da Vinci in AC2. Out-of-series, he's also Dom.
Playing Against Type: In the Japanese version, Ayako Kawasumi and Kaori Nazuka are normally typecasted in Anime voicing heroic or kinder roles. In this game, both actresses voiced two of the most cruelest women of the Renaissance: Lucrezia Borgia and Caterina Sforza, respectively.
Ezio, Cesare and Lucrezia were Gilgamesh, Archer and Saber respectively. Special mention towards the relation between Ezio and Lucrezia since their roles are switched out from their roles in Fate.
Values Dissonance: It's all over the pages how awesome Caterina Sforza's speech is in the DLC, and how she really said that in real life, which makes it more awesome. We're talking about 16th century Europe, where that sort of behavior from a woman would probably have been considered shocking and obscene, worthy of, if not death, then banishment. She was probably unpopular merely for being a woman in a man's job. In other words, we can't know if she actually said and did those things with certainty, especially as she was judged very harshly by history, even in contrast with other female rulers who typically get the fuzzy end of the lollipop regardless.