- Actor Allusion: Skylar's daughter asks her at one point "Are you a terminator?" She is.
- Fake American: Ryan Cartwright (Gary) is actually from England.
- Follow the Leader: It has some similarities to The 4400.
- Screwed by the Network: It took around three months for Syfy to announce the show would be cancelled, after so much hope was generated for season three. An interesting example because Ryan Cartwright (Gary's actor) initially posted on his Twitter that he will assume Alphas is cancelled after waiting so long to "decide" and this forced Syfy to react and contradict him. Of course in the end, it was still cancelled, serving as a Kick the Dog moment for the fans.
- You Look Familiar: Brent Spiner has appeared in both Alphas and Warehouse 13 playing different characters. Notable as this is the first time they've reused an actor in a different role since the series was established to exist in the same universe as Eureka and Warehouse 13. note
- Kimi Milard (Sarah Slywchuk) actually had one openly spoken line of dialogue in the entire second season, though it was cut for unknown reasons.