* ActorAllusion: Skylar's daughter asks her at one point "Are you a terminator?" [[Series/TerminatorTheSarahConnorChronicles She is.]]
* FakeAmerican: Ryan Cartwright (Gary) is actually from England.
* FollowTheLeader: It has some similarities to ''Series/TheFortyFourHundred''.
* ScrewedByTheNetwork: It took around three months for Syfy to announce the show would be cancelled, after so much hope was generated for season three. An interesting example because Ryan Cartwright (Gary's actor) initially posted on his Twitter that he will assume Alphas is cancelled after waiting so long to "decide" and this forced Syfy to react and contradict him. Of course in the end, it was still cancelled, serving as a KickTheDog moment for the fans.
* YouLookFamiliar: Brent Spiner has appeared in both ''Alphas'' and ''Warehouse 13'' playing different characters. Notable as this is the first time they've reused an actor in a different role '''since''' the series was established to exist in the same universe as ''Eureka'' and ''Warehouse 13''. [[note]] The latter series reused actors, but this happened long ''before'' the crossover occured.[[/note]]

* Kimi Milard (Sarah Slywchuk) actually had one openly spoken line of dialogue in the entire second season, though it was cut for unknown reasons.