* ActorAllusion: Skylar's daughter asks her at one point "Are you a terminator?" [[Series/TerminatorTheSarahConnorChronicles She is.]]
* CaliforniaDoubling: Set in New York City, filmed in Toronto.
* FakeAmerican: Ryan Cartwright (Gary) is actually from England.
* FilmingLocationCameo: At the end of the season 1 episode "Catch and Release", some of the characters travel to Toronto.
* FollowTheLeader: It has some similarities to ''Series/TheFortyFourHundred''.
* PlayingAgainstType: Skylar's first episode initially appears to portray her as the kind of crazy superpowered teenager that Creator/SummerGlau was famous for playing in ''Series/{{Firefly}}'' and ''Series/TerminatorTheSarahConnorChronicles''. This makes the revelation that she's trying to save her own daughter much more of a surprise, since nobody would expect that type of character Glau normally played to be old enough or stable enough to be bringing up a kid.
* ScrewedByTheNetwork: It took around three months for Syfy to announce the show would be cancelled, after so much hope was generated for season three. An interesting example because Ryan Cartwright (Gary's actor) initially posted on his Twitter that he will assume Alphas is cancelled after waiting so long to "decide" and this forced Syfy to react and contradict him. Of course in the end, it was still cancelled, serving as a KickTheDog moment for the fans.
* YouLookFamiliar: Brent Spiner has appeared in both ''Alphas'' and ''Warehouse 13'' playing different characters. Notable as this is the first time they've reused an actor in a different role '''since''' the series was established to exist in the same universe as ''Eureka'' and ''Warehouse 13''. [[note]] The latter series reused actors, but this happened long ''before'' the crossover occured.[[/note]]

* Kimi Milard (Sarah Slywchuk) actually had one openly spoken line of dialogue in the entire second season, though it was cut for unknown reasons.