The Amazing Adventures of the Living Corpse: Dr. Brainchild, who's perfectly willing to start zombie outbreaks, kidnap children, make them work for him, and throw their lives away to achieve true resurrection. He doesn't even want to do it for any good intentions, simply For Science!
Steele from Balto is a malevolent Jerkass that masquerades as the town hero and keeps his fellow race dogs in line through fear, bullies and torments Balto because he can, his behavior towards Jenna is... disturbingly predatory, and, most reprehensibly, was willing to allow Balto along with his former teammates to perish in a blizzard and was willing to allow the town's children to die slow, painful deaths of diphtheria all so he could twist the events around to make himself look like the hero.
Chicken Run: Mrs. Tweedy. At first it might seem that she's just a harsh, ambitious woman whose job involves killing poultry but, as the movie progresses, she proves to be extremely callous and self-centered, to the point that she treats her husband as a mere tool for her plan. She's also prone to fits of anger and seems to enjoy killing chickens. Just like many real life sociopaths, she's able to hide this traits behind a veneer of politeness when it conveniences her.
Coraline: The Other Mother must eat life energy to survive, but goes about it in the cruelest way possible. She finds children unhappy with their lives, and creates a world that appears to be anything they want. After a time, she convinces them to sew buttons on their eyes, trapping their ghosts behind a mirror. If they refuse, she drops the mask and imprisons them and their parents until they do. She has an impulsive love of games, but will cheat to win them, and immediately reneges on any deals made if she does lose.
Krishna Aur Kans: King Kans, who imprisons his cousin and murders dozens of her babies to keep himself in power, ultimately setting a demoness he knows will murder hundreds of kids when one of them escapes.
Kung Fu Panda 2: Lord Shen is certainly an odd example. As an extreme Narcissist who believes that he is above all others, Shen has inordinate self-worth, a sense of self-entitlement, is violent, unsympathetic and more than willing to kill anyone who questions him. On the other hand, he does show some mercy to the Soothsayer and wishes he had his parents' validation. This would make him a subversion, but his overwhelming need to be on top of everything and everyone cancels out everything else.
A Matter of Loaf and Death: Piella Bakewell. Her revenge is as petty as they come, she has absolutely zero remorse for her killing spree, and even her pet dog is just a tool that she couldn't care less about.
Megamind: Hal Stewart/Titan believes he's entitled to have Roxanne no matter what, and when she rejects him, he uses his powers to go on a rampage throughout the city, completely uncaring of who's going to get hurt or killed in the process.
Monsters vs. Aliens: Gallaxhar is a genocidal alien warlord who has no problem trying to wipe out an entire planet in order to replace the population with clones of himself. He even nonchalantly mentions that he destroyed his own home planet, fully aware that there were innocent people on it.
The Storm King from My Little Pony: The Movie (2017). Charming enough to win the trust of the ultra-cynical Fizzlepop Berrytwist, alias Tempest Shadow, and when he got the powers spent his time messing with the day-night cycle for his own amusement. He cast Tempest aside when he had no further use for her, and conjured up a storm without thought for his own guards' being in the way.
Puss in Boots: The Last Wish: Big Jack Horner is a wealthy heir to a bakery who is also a crime boss who hoards magical items. He cares only for power and world dominance. Several of his henchmen are killed during his quest; some of them he personally kills by accident while using his magical items, and he doesn’t care. He uses some of them as a bridge to cross a cliff, and most of them end up falling to their deaths. He only spares one of them on the grounds that she won’t talk to him, only to later sacrifice her to save himself. When the Ethical Bug (the film's version of the Talking Cricket) discovers he has no excuse for his evil deeds, he calls him an irredeemable monster. Jack's only reply is to call the Bug an idiot for not realizing that sooner.
Mok Swagger from Rock and Rule. An aging rock singer, Mok proudly proclaims he's the "greatest thing since World War III," and wishes to summon a demon to massacre his audience at a staged concert because they didn't love him enough. He has moments of superficial charm when trying to manipulate Angel into lending her voice for this operation, and goes as far as to torture her friends with Edison Balls to force her compliance. He also doesn't care about anything or anyone not useful to him, as seen when he reacts nonchalantly to the death of one of his henchmen.
The Fairy Godmother in Shrek 2. She views Fiona as nothing more than a way to power and is completely unconcerned with her feelings unless they suit the Fairy Godmother's needs. When she sees Fiona does not love her son, she is only concerned with the power she will lose and creates a love potion to ensure Fiona falls in love with Charming. Fiona's father Harold owed her a favor and she blackmails him into giving Fiona the potion. This ultimately fails as Harold has a Heel–Face Turn, deciding last minute not to give Fiona the potion and eventually accepts his formerly despised son-in-law.
The Super Mario Bros. Movie: Bowser. In a stark contrast to his game counterpart, who was given many redeeming qualities over the years as part of Characterization Marches On, this version of the Koopa King has all the textbook traits of a sociopath whether it'd be his lack of care for anyone that isn't himself, his unhinged personality and violent mood swings, his total Lack of Empathy, and overall being a murderous psycho who will kill anyone who gets in his way. Even Peach, the one person that he does seem to "love" (even then in his own morbidly twisted and warped way), he does not hesitate at all to hurt or even kill when she dares to refuse to marry him and even has no problem making her watch one of her own Toad followers get slowly tortured and slowly killed right in front of her just so he can force her to do what he wants.
Where the Dead Go to Die: Daddy, who makes child porn of his daughter and hangs her from the ceiling when he dislikes her behaviour.
