Please don't list this on a work's page as a trope. Examples can go on the work's YMMV tab.
Tear Jerker: The Magic School Bus
Tear Jerker: When D.A. loses her book bag and self-confidence in in "Blows its Top".
Keesha's Heroic BSOD and subsequent ten-minute retirement in "Gets Ants in Its Pants".
The Bus almost gets flattened in "Revving Up". The music does not help.
Tough girl Wanda actually cries in "Holiday Special" when her favorite toy from early childhood, which she'd intended to give away to other children who otherwise wouldn't get Christmas presents, gets mulched up and melted down into plastic pellets instead.