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Tear Jerker: Starman
If the ending doesn't make you at least misty, you have no soul.
The television show
When Starman wears "his" old cap from the film, Jenny (not knowing who he really is) becomes upset. It's a touching, sad moment.
The comic book
Ted Knight's death and even worse, funeral at the end of the '90s Starman run. There's just something about seeing those characters walk up and say their piece that had this troper needing to put the comic down for a few minutes.