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Tear Jerker: Drakengard
The very first ending you get in the first Drakengard game is truly a tearjerker. Not only does Angelus show her change in opinion of humans but also Caim finally shows compassion for the first time (we are talking about a guy who killed thousands of people in cold blood and didn't cry when he lost all his soldiers, his sister, and even his best friend). The sequel only pushes it further although it can be actually comforting in that they do not have to suffer anymore.
And in the sequel? As the two burn to ash, sharing one last moment together in life as Growing Wings, the series Leitmotif, plays, the following exchange occurs between the two pact partners: