He is a man of good birth and excellent education, endowed by nature with a phenomenal mathematical faculty. At the age of twenty-one he wrote a treatise upon the binomial theorem which has had a European vogue. On the strength of it, he won the mathematical chair at one of our smaller universities, and had, to all appearances, a most brilliant career before him. But the man had hereditary tendencies of the most diabolical kind. A criminal strain ran in his blood, which, instead of being modified, was increased and rendered infinitely more dangerous by his extraordinary mental powers. Dark rumours gathered round him in the University town, and eventually he was compelled to resign his chair and come down to London... He is the Napoleon of crime, Watson. He is the organiser of half that is evil and of nearly all that is undetected in this great city.
—Sherlock Holmes on Professor Moriarty, "The Final Problem"
Doctor: Just one small question, ah... why do you want to blow up the world?
Zaroff: 'Why?' You, a scientist, ask me why? The achievement, my dear Doctor! The destruction of the world! The scientists' dream of supreme power!
"Can you believe it? Wimpy old Professor Warren—and look at me! Able to take on not one, but two Spider-Men at the same time! I'd like to see the nitwits at NSU deny me tenure now! "
— The Jackal, The Clone Saga
"Dr. Francois Duvalier was the former President for Life of Haiti, a title which he gave himself because that's the kind of thing you do when you're a crazy dictator. His father was named Duval Duvalier and was a judge while his mother, Ulyssia Abraham, was insane. The only thing missing was exposure to radiation to help him on his way to perfecting his villainy."