Alice is a mean old recluse who makes a point of chasing everything off, especially cats.
Alice is a cat who has a house full of old ladies.
Bob is a sane young man that has one, and just one, dog.
Alice has some cats, but also an active social life with humans.
Alternatively: Alice barely even talks to other people when she's out in public, and refers to taking things home to her "darlings"... Which turn out to be dolls.
Alice isn't a Crazy Cat Lady (indeed, may not even have a pet), but she is a Christmas Cake, and her family and friends try to "motivate" her to find a man by saying that she'll turn into a CCL if she doesn't find one and settle down soon.
Double Subverted: The only humans she interacts with are her relatives, or members of the Feline Appreciation Society.
Zig Zagged: Sometimes Alice interacts with her pets, other times with actual human beings.
Averted: Alice does not have any pets, not even a betta fish.
Enforced: The writer is a Christmas Cake, and worries that this will be her fate.
Lampshaded: "How many cats does Alice have, again?"
Invoked: Alice was a victim of Abusive Parents at a young age and the only friend she has was a cat, now she's old with the mindset that her only friends are cats.
Exploited: Bob knows that Emperor Evulz is allergic to cats, so he leads Evulz into Alice's house and defeats him at his weakest.
Defied: Alice doesn't have much of a social life, but refuses to substitute animals for human affection. Instead, she resolves to get out and meet people and do things.
Conversed: "Poor Alice. She should really get out and meet people."
Discussed: "Cats are no substitute for human affection. And why cats anyway? Everyone knows Cats Are Mean. Can you say, Irony?"
Deconstructed: Alice hoards cats because she feels alienated from other humans. She craves human interaction, but can't break out of her shell, and so she gets more cats. The loneliness builds up into actual craziness. And as she becomes more and more detached from reality, her house and her cats begin to suffer for it.
Reconstructed: Alice seeks help for her social anxiety. She brings the cats to the local animal welfare society, or adopts them out to loving homes herself (except maybe one or two). She eventually comes out of her shell and develops an active social life.
Played For Laughs: Alice not only has a lot of cats, but she's a board-certified Cloud Cuckoolander.
Played For Drama: Alice and the cats are suffering, but Alice is too far gone to realize it.
Go back to Crazy Cat Lady, unless you want to meet my pretties. They don't scratch...