In general, many players will take on this trope also as a means to avoid the cliché plotline of having the villain kidnap the player's parents as hostages. For many other players, this is just an easy character development device to justify their character's attitude towards the world.
The Vampire: The Masquerade and Mage: The Awakening core rulebooks specifically advise players not to play orphans or people who are estranged from their parents specifically because this trope is used so often and there are lucrative storytelling possibilities involved in having mortal/Muggle friends and family.
Present in Warhammer 40,000: the Emperor's twenty clone sons were lost in a warp storm due to the Chaos gods and scattered across the galaxy to be raised by whoever-or whatever-found them. Wolves, on one occasion.