No Biochemical Barriers
Puny humans, surrender your Doritos to the Swarm or be destroyed!

R2: Obviously the air is highly caustic and poisonous.
Obi-Wan: Apparently not.

In Speculative Fiction, it is far too often the case that writers do not take into account the fact that the differences between terrestrial species and their alien counterparts would run deeper than appearance alone. Given that alien species would have evolved in environments vastly different to terrestrial ones, contending with different atmospheric conditions, different levels of background and cosmic radiation, different soil conditions, different pathogens and parasites, and so on, it is patently unlikely that any aspect of their biology would be directly compatible with their terrestrial counterparts. Aliens in speculative fiction are usually depicted less as properly alien creatures and more like humans from another country, and alien animals are merely exotic species from a different climate.

This, then, means that you will often find one or more of the following in speculative fiction:

  • Half-Human Hybrid - the most blatant offense against conventional biological wisdom. See that entry for examples.
  • Alien Food Is Edible - Humans and aliens are able to share food and drink. As an extension of this, humans or aliens shown as being able to derive sustenance from utterly alien animal or plant life. (Aliens eating humans also falls into this category.)
  • Cross-Species Disease - Humans or aliens affected by alien pathogens or parasites that should not have had time to adapt to a different species' physiology. Even on Earth, most viruses, bacteria, and parasites only affect a single species or a few related ones, and so-called "zoonoses" have generally only been a big deal amongst livestock, which we've intentionally cultivated in close proximity for ages.
  • All Atmospheres Are Equal - While species that breathe something other than oxygen are sometimes seen wearing protective gear when moving in oxygen-based atmospheres, species that are capable of breathing an oxygen-rich atmosphere are never shown to be hampered or even affected at all by the other gases (nitrogen, for example) that constitute the air familiar to humans. Nor do they suffer any problems related to the air pressure — presumably, All Planets Are Earthlike.

Some of these are more plausible than others, although not by much. While there is reason to believe that Earth's atmosphere carries life because it is particularly suited to life, this is basically a confirmation bias — we consider it suited to life because it is suited to our life. This position is called the anthropic principle.

Similarly, some people claim that most life-forms in the universe would be fundamentally compatible with each other because they would be formed from the same basic chemicals. Considering that life on other planets wouldn't even necessarily be carbon-based,note  this is a very naive position. Also, arsenic is one of those "same basic chemicals" as well.

This is one of the problems to watch out for in How to Invade an Alien Planet. A technological counterpart is Plug 'n' Play Technology. If different species (including, for example, humans and aliens) are shown reacting to drugs in exactly the same way despite biochemical barriers, see One Dose Fits All.


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Alien Food is Edible

  • In Axis Powers Hetalia, Alfred's alien-buddy Tony is regularly seen snacking on the same fast-food junk Alfred does.
  • In Birdy the Mighty, Birdy can eat human food, and quite enjoys it, but needs to eat a lot more of it to survive.
  • In Death Note, Shinigami don't need to eat, but many enjoy human food anyway, as a form of Alien Catnip. Ryuk likes apples, and Sidoh likes chocolate.
  • Please Teacher!. Aliens love Pocky.
  • Dita Liebely, the female protagonist of Vandread, samples the food from Hibiki Tokai's home planet, but she finds it revolting and inedible. Believing the opposite must be true for Hibiki, she feeds him food from her home world, which he found to be delicious. Following this, Dita has little problem spending time with Hibiki on the condition that she feed him. Although Dita considers Hibiki to be an alien lifeform, most outsiders would point out that they are the same species, just different genders.

    Comic Books 
  • Green Lantern. The human Green Lanterns have problems getting good food at the Oan cafeteria. The chef just isn't that skilled.
  • In the backmatter for the second volume of The League of Extraordinary Gentlemen, this is a problem for Alice of all people after she returns from Wonderland through the looking glass. Her whole body is reversed left-to-right, so her hair part is on the wrong side - as is her heart. Then, she mysteriously dies of malnutrition, despite eating normally for a while. It's not explained in the text, as Victorian science wouldn't be able to figure it out, but the science-minded reader might conclude that the reversal extended all the way down to the molecular level, and that Alice's digestive enzymes were backwards compared to the molecular substrates in her food.
    • This could also be a reference to a part of Through the Looking Glass and What Alice Found There, where she briefly wonders if "backwards milk" would be good to drink. The Annotated Alice discusses the effects of food with "backwards" molecules and how they would basically be poison, concluding that no, backwards milk would not at all be good to drink.
  • Tenzil Kim and his fellow Bismollians from Legion of Super-Heroes can eat anything, except certain materials he specifically can't use his power against.
  • In Tom Strong #16, it's established that while unaltered humans can eat Devil's Footstool food, the opposite is not true. (With a few exceptions, such as coffee.)
  • In Transmetropolitan the Vilnius and late-stage transients (humans turning into Vilnius) can't eat human food, which helps influence the transient secession movement in the first volume.

    Fan Works 
  • A mild aversion in Red Fire, Red Planet. Ens. Kate McMillan offers her Xindi-Primate superior a cup of coffee but Lt. Medrona reminds her that caffeine is bad for the Xindi stomach lining. She accepts a cup of herbal tea, though.
  • Downplayed in Speak Now Or.... The human being can digest The Crystal Empire berries, but they taste really, really bad.
  • Averted with the races of the Terran Systems Alliance in the story Tyrant Kings, a Mass Effect and Jurassic Park crossover, as due to Earth having both Levo-amino acid and Dextro-amino acid based life, they can basically ignore what is otherwise a fairly serious and dangerous barrier to the rest of the galaxy.
  • In An Intergalactic Halloween, a human is mentioned as having five separate bowls of treats for various alien races. At one point a Yvorn (basically a space vampire) tries apple cider but can't quite hide how disgusting she finds the stuff. Though oddly, everyone can breathe the same air just fine.
  • In Sailor Orbital Blue Oyster stops Kikai from eating Earth food based on this very issue. Kikai assures her that she recently used a magical spell to "align" herself with a native animal and so she's perfectly safe.

  • Many films where aliens, particularly sentient ones, eat humans (humans being eaten by alien beasts can be explained by the alien eating things that act like prey without knowing that it's bad for the alien's health).
  • Alien Nation: Newcomers can survive on Earth, but there are noted differences in their needs. They cannot drink (or even touch) salt water because it burns them like battery acid. Spoiled milk gets them drunk, so they drink it as a beverage rather than alcohol, which has no effect. The TV spin-off greatly expands on Newcomer differences.
  • Averted in Avatar, in which Jake doesn't get to try native fruit until he's in his avatar body, which is designed to accept such fare.
  • The aliens in District 9 eat a lot of beef and pork, and have a craving for tinned cat food. There are some biological differences though: they don't just enjoy eating cat food, it tastes so good that it verges on being an addictive drug. It's described as being sort of like catnip is for cats to them, only a lot more intense. Initially this is played for laughs, until we later see aliens selling off advanced technology or even alien children for a few cans of it. They also like to chew tires, though it isn't clear if they can digest it, or if they just enjoy chewing it, like bubble gum.
  • The Men in Black films and cartoons imply that all alien immigrants and visitors to earth can eat (or appear to eat, in the case of the Mobile-Suit Human-wearing Arquelliens) human food, although most of them need to in order to live as ordinary humans. Presumably those that can't eat Earth food find more-palatable corners of the galaxy to hang around in.
  • Averted for comic effect in Galaxy Quest, when the actor that the aliens think is an alien is treated to food from his "native" planet... seaweed-like stuff and live bugs in a bowl of water.
  • Though it's frequently derided today for the Fridge Logic that it inspires, the infamous Twist Ending of Signs is essentially an aversion of this trope. Just when the alien invaders seem invincible, it turns out that water—the most abundant substance on Earth—is actually a corrosive chemical to them, and it burns their skin like acid.

  • In Neal Stephenson's Anathem, it is shown that chemicals from other space-time continua will not react with those present in the protagonist's continuum (though light elements such as oxygen react, though more weakly, making the atmosphere just breathable to the travellers). This results in the food not being toxic, but being indigestible, resulting in it passing through a digestive tract unchanged. Similarly, alien pathogens are explicitly mentioned as being no threat, at least until they've had a chance to evolve a little.
  • Animorphs uses that trope a lot, with varying plausibility:
    • Andalites are a species which somehow eat grass with their hooves. Whether grass is something unique to both the Andalite planet and Earth or just a common biological formation for most inhabited planets is not developed.
    • Similarly, Taxxons can apparently eat anything that bleeds. Also, Hork-Bajir are capable of eating the bark of Earth's trees, although they don't really like it.
    • The technology that game the series its name is based on absorbing DNA. It starts to make sense with The Elimist Chronicles, which explain that the Ellimist created the Pemalites to seed life on as much planets as possible, to beat Crayak at their "Will all life in the universe be utterly destroyed or not" game, so they probably used the same DNA-based cell for each one.
  • In Chasm City by Alastair Reynolds, one human is tortured by being fed to a hamadryad (a giant snake-like alien) which swallows him whole and promptly dies due to terran proteins being lethally toxic to it. The victim is cut out of the creature's stomach, still alive if a little unhinged by the experience.
  • C. J. Cherryh's works:
    • Tully, the sole human in the Chanur Novels, has no problem with Hani food.
    • In the Foreigner series humans must be very careful as to what atevi food they eat. Many "teas" and seasonings are deadly to them. The atevi can eat all human foods without problem, though human food is lacking in essential atevi vitamins, so an atevi can't survive on only human food.
  • In the universe of The Color Of Distance all life-bearing worlds but Earth are inhospitable to humans. Allergic reactions to even things in the air are quickly fatal, so they go everywhere in environment suits. Tiangi, however, is home to the Tendu whose healing and life-reshaping powers mean they can adapt themselves to have no trouble on other worlds, and treat the allergic reactions of humans or create a "skin" that protects human outsides and insides from the air and water. One human with such a "skin" is wounded once, breaking it, and has to be healed.
  • Averted in the Corean Chronicles. The world was colonized and mildly terraformed to allow humanity to survive. The majority of the surviving fauna and flora is completely alien to their biology, consisting largely of Life Energy interwoven with the natural elements of the land. The meat of nightsheep, the only known fleshy creature able to subsist on native flora, is poisonous to humans.
  • In The Court of the Air, the crab-like craynarbians are unable to stomach human jinn (gin), which makes them vomit and slows their heart rate dangerously.
  • Averted in Courtship Rite, by Donald Kingsbury, where humans on an alien planet can eat nothing but the ""sacred eight" organisms which survived their arrival. There is some talk of being able to process a few types of the native plants to make them non-toxic, and of carefully selecting the edible bits of other native species. Some groups of humans have deliberately selected themselves for greater resistance to the poisons in the native organisms. The available foods include honey bees (the only other animal besides humans) and wheat. Cannibalism is part of the culture, with baby's tongue being a delicacy!
  • Used somewhat in Allen Steele's Coyote. A colony ship of humans going to a new, alien world doesn't know, while in orbit, if the planet has the right kind of soil(dextro versus levo amino acids may have been involved) to grow Earth crops; the colonists couldn't have survived on native food from the wrong kind of soil. They were lucky.
  • Averting this trope is the whole premise of Larry Niven's Destiny's Road, where human colonists populate a biochemically incompatible planet. People gain no sustenance from native life (and vice versa). They live on transplanted Earth animals and plants, but something different about the place means essential nutrients are missing, so humans must regularly consume something called "speckles" or go insane and die. The native life does not contain fat, or (key plot point) potassium (with the exception of a few plants). You CAN survive on the native life forms (at least for a lot longer than by starving) but you'll gradually lose all body fat, so makeup and source of "speckles" is a major plot point. This is used by a character trying to lose weightnote , as you feel full, but your system can't process the food. You excrete everything and keep nothing—rapid weight loss happens then.
  • Also subverted in Pratchett's Discworld novel "Moving Pictures".
    Troll: I knows what they say about us trolls, but it not true! We made of rock. We don't eat humans!
    Other Troll: Swallow. We don't swallow.
  • In Roger Zelazny's Doorways in the Sand, the main character stays on Earth, but gets run through a dimensional inverter, resulting in him being mirror-flipped. The first time he tries to drink beer he realizes that all molecules are now backwards to his physiology and he had better stick with food and drinks that have symmetrical molecules, or else he'll poison himself.
  • It is mentioned in a Dragonriders of Pern novel that humans cannot eat any of the native Pern plants and can only eat the plants originally brought from Earth, but they can eat the native animals.
    • Yet Klah (the coffee analogue) is made by steeping tree bark from a native Pern plant...
    • McCaffrey also averted this trope in Dinosaur Planet, in which the exploration team heavily tests any local organism they consider using for food. Also, the intelligent pterodactyls that were transplanted from Earth to Ireta separate out any native fringe-organisms from their fishing nests and discard them as inedible.
  • Played with in the sci-fi novel Godspeed, a human colony world is cut off from the rest of civilization after something went wrong with every hyperdrive in the galaxy at once. Without imported food from Earth, the colony has to grow its own crops. While they're edible, and humans can live off them pretty comfortably, the local food has two severe health effects: one, puberty is delayed by nearly ten years, and two, something in the food causes a gross imbalance in the ratio of boys to girls born, such that girls are extremely rare. It's a plot point that unless they find a way to counteract this, the planet's population will collapse within a generation or two.
  • Present Ursula K. Le Guin's Hainish novels. Characters from one planet frequently live on other planets, sometimes for years at a time (Genly, a Terran, on Gethen in The Left Hand of Darkness and Old Music, a Hainishman, on Werel in several short stories, among others). May be justified given that all of the people involved evolved from a common race, the Hainish, and so may have sufficiently similar biology to be able to eat one another's foods without complication.
  • Peter F. Hamilton
    • Averted in Fallen Dragon, where alien ecosystems are completely incompatible with human biochemistry — meaning the first step in colonizing a new world is to irradiate patches of land to kill native fauna and flora and reseed it with terrestrial organisms.
    • Played straight in The Night's Dawn Trilogy, where many exotic foodstuffs are imported from alien planets, and earth plants are genetically tweaked to grow on other worlds; the best alcoholic beverage in the Human Confederation is made from the water accumulated in the flowers of Norfolk roses. A short tale describes how some of the first scientists to land there, while inspecting the local flora, tasted said water. Norfolk was cleared for colonization days later as a result.
  • The Hitchhiker's Guide to the Galaxy
    • The Restaurant at the End of the Universe has approximately 85% of sentient races having a drink called a "gin and tonic" (or "jynnan tonnyx", or "jinond-o-nicks", or "gee-N'N-T'N-ix", or "chinanto-mnigs", or "tzjin-anthony-ks"...). However, all these drinks are radically different, ranging from a gin and tonic to ordinary water at slightly above room temperature to a drink that supposedly kills cows at a hundred paces. Yet they all have the same name, and were all named such before the races had discovered space travel. This may also apply to Ouisghian Zodahs.
    • Also specifically averted, as Ford tells Arthur that things like nuts and berries native to alien planets may well kill you. (Or they may not, but there's normally no way to tell except to try them, so only try them when you're at the point of dying if you DON'T find something edible.)
  • Honor Harrington:
    • The title character is stranded on an enemy Prison Planet that was chosen because none of the native, plants or animals were edible to humans at the best of times and very toxic most of the time. Thus prisoner populations of millions could be controlled by a hand-full or guards by spreading the prisoners in remote camps and flying-in their food. A species of plants is found to provide nutrition for humans but has devastating neurological effects. Conversely, native "shuttlesquitos" love to suck human blood — but quickly die from it.
    • The treecats in the Honorverse obtain zero nutritional benefits from most celery, but absolutely love the stuff: celery modified to grow on Sphinx contains a chemical that helps maintain their telempathic abilities, and tastes better than the bitter-tasting native plant that was the source of the chemical before humanity arrived. They just eat the other celery because it tastes good. But since they're mostly carnivores over-indulging in celery causes digestive problems because of all the fiber...
  • Both played straight and averted in the Humanx Commonwealth universe of novels by Alan Dean Foster. The vast majority of species in the galaxy seem to be able to exist just fine on the same basic foodstuffs and in similar atmospheric conditions, though they rarely find it comfortable or life-threatening; for example, Thranx consider Earth's tropical jungles to be cool and arid. To be sure, analysis is required to ensure compatibility before attempting to eat strange foods, and there are some cases where things are explicitly pointed out as being toxic to certain species, but the trope is obeyed in a general sense. One amusing application of the trope is that drug laws are all but impossible to enforce; just about every species has something another considers Alien Catnip as part of its essential diet.
  • The food of one planet is inedible to a native of another planet in The Madness Season. In addition, the main character, a shapeshifter is only able to transform into creatures native to the planet Earth.
  • Averted in The Mote in God's Eye. After a good deal of biochemical research, the Moties eventually come up with some local foods that the humans can eat. Moties find coffee about as lovely as torture, but they do like hot chocolate. With a drop of machine oil in the cup.note 
  • Averted in Eric Flint's Mother of Demons, in which humans can eat nothing on the planet Ishtar but "childfeed", which is semidigested plant material regurgitated by large herbivorous lifeforms (normally to feed their offspring). Additionally, it turns out that the meat or bodily fluids of every animal on the planet are deadly poisonous to humans—but then, it also works the other way around.
  • In the 1992 novel Murasaki, written by several well-known science fiction authors, this trope is averted in an almost sad way. Humans discover the planet Murasaki and mount an expedition. The local life is almost completely poisonous to humans because they use a wider variety of amino acids. The natives, in an effort to make friends with the humans, find one life form that has some parts that are edible to us and present them in a feast. They are delicious. But they are also now extinct. Every last of the animals was harvested in order to provide the feast.
  • Averted in the My Teacher Is an Alien series: when a human on a space ship full of thousands of species goes to the dining hall, a couple of crewmembers analyze his biochemistry and hunt through the menu/database for something that they're almost certain will not make him vomit or drop dead.
  • Usually played straight in John W. Campbell's Penton and Blake stories, in which Penton and Blake are able to eat Callistan jelly fruit and stragath (although the latter squicks Blake out because it tends to move around while you're trying to eat it). Averted in "The Brain Pirates", though, when Penton and Blake become stranded on the outer-system satellite Pornan and fear starvation because all the food there is full of heavy metals.
  • Zig-zagged in John Ringo and David Weber's Prince Roger series.
    • Mardukan life forms are similar enough to Earth's that most of them can be at least partially digested by baseline humans, but the operative word is partially.
    • For all its similarities, Marduk is still an alien planet, and a particularly nasty one at that. Several key micronutrients are just not present in Mardukan life-forms, and micronutrient deficiencies are an ever-present threat.
    • The titular prince and his bodyguards have an easier time handling nutrient deficiencies that their civilian auxiliaries because they have genetic modifications and nanite packages tailored to help them in exactly this type of situation. However, even their nanite packages can't create complex things like vitamins out of base elements.
    • Some Mardukan poisons do not affect humans at all, and others are in fact useful as nutrient supplements. One poison which is instantly lethal and tasteless to Mardukans is harmless to humans, and has a very strong taste of rotten fennel.
    • When Roger discusses bringing Marduk into the Empire in practice instead of just on paper, one of the Mardukan commodities he thinks would find a good market in the Empire is their staple crop, dubbed "barleyrice" by the humans. To humans, barleyrice is both more flavorful and nutritious than terrestrial grains.
  • From the works of John Ringo:
    • In the Into the Looking Glass series, mostly co-written with Travis S. Taylor, the alien food is used as a diet plan, because while filling, it has no nutritional value, and thus doesn't provide energy in a form human biochemistry can use. Used in that anyone from one of the four biological patterns (called Green, Blue, Red and Orange based on the version of chlorophyll found) can eat anything of that pattern. However, even same-pattern foods may or may not be nutritious, or even safe- there's just a better chance of it being digestible.
    • Also used and averted in another Ringo series, Legacy of the Aldenata, the Posleen are a ravening horde of Extreme Omnivores who can and will eat anything, including each other, but are immune to infection and disease of any kind. However, its justified by the fact that the Aldenata were trying to modify them into a less violent species. Oops. This trope is even lampshaded by a member of a crustacean-like species trying to convince humans to abandon its attempts at developing biological and chemical weapons against the Posleen. Obviously, when the survival of one's species is at stake, ethical considerations are a hard sell, but once it was pointed out that any human exploiting its resemblance to a terran lobster would grow sick if not die from the alien biochemistry, while the Posleen are unhindered by such considerations, it became clear that any attempt at creating a biochemical weapon that would 'zap' Posleen but leave humans and their allies un-harmed was a fool's errand.
    • This gets subverted in Ringo's latest series, Troy Rising, where maple syrup is an incredibly potent alchohol-like substance for one of the alien races.
  • Averted in Larry Niven's Ringworld: the protagonist mentions that he once survived an attack by an alien beast because it stopped to swallow the chunk of him it had already ripped off and promptly curled up and died, poisoned by his biochemistry. And Justified in the case of those lifeforms that evolved from abandoned Slaver foodplanets, like Earth and Kzin.
  • In addition to the disease issue, this is also brought up in the Sector General novels. Specifically, the cafeteria at the hospital has a very wide selection of foods on the menu, with notations as to what foods can be safely eaten by what species. Occasional problems come when a diagnostician comes in for lunch after having a tape personality active for awhile, and as a result has to force himself to pick a meal that is suitable for his actual body rather than what his alternate personality thinks he is, and then force himself to eat what looks to be a highly unappetizing substance from the tape personality's perspective.
  • This trope goes all the way back to the first Space Opera, The Skylark of Space. Though the main characters are initially wary of eating Osnomian food, Seaton gives some Earth spices (as well as cigarettes) to an Osnomian without being at all worried for the alien's health.
  • The Apicians in the Cordwainer Smith short story "From Gustible's Planet" are capable of eating Earth food (and think it's delicious). This is specifically said to be unusual, though.
  • Averted in 2061 by Arthur C. Clarke. A spaceship lands on Europa, one of the crew is killed, and the corpse is eaten by a large water creature. Said creature promptly dies, because the biochemical differences means that human flesh is poisonous to it.
  • Averted beautifully several times in Speaker for the Dead and its sequels.
    • A human colony on an alien world has to grow their own crops because alien plant species are either inedible or nutritionally useless. They are also trying to genetically alter the local plant life to make it a food source for humans.
    • The humans have to genetically engineer their own wheat crops in order for the natives to be able to eat it.
    • The locals on the colony world can eat one of the native grasses and it acts as a pain suppressant. Several major plot points revolve around the fact that the grass has no effect on humans.
    • The planet is ALSO home to the most deadly virus-like diseases in the known universe (it has a nasty habit of "ungluing" DNA, splitting the helix into two useless strands and killing the cells in a horrifying and painful manner). It turns out that not only is this disease rapidly "learning" to overcome what protective measures the human colonists have devised it is also essential for the life-cycle of every native species on the planet meaning any attempt to simply eradicate it would essentially be Xenocide.
  • Averted in Star Carrier. Life-bearing worlds are hard to come by as it is, and those that are habitable by humans are few and far in between. Among the worlds colonized by humans, only two have breathable atmosphere, and only one has the native life with the same exact biochemistry as terrestrial life, allowing the colonists to eat local life. In fact, the plot of the fifth novel is the discovery of a new alien race whose biochemistry matches human norms... and they like the taste of human flesh... and the Too Dumb to Live Confederates have just shown them where Earth is located.
  • David Weber's Starfire novels In Death Ground and The Shiva Option have a Bug War against aliens who eat all sapient species, and breed them as food sources on conquered planets because everything made of meat is food to them.
  • Unusually for Star Trek, it's averted in Articles of the Federation. The Trinni/ek food fleer/ok has to be removed from the menu during preparations for a state dinner welcoming the Trinni/ek Speaker. It's determined to be poisonous to Bajorans, Betazoids, Humans, Trills, and Vulcans, and causes an allergic reaction in Tellarites.
    • Also in Diane Duane's My Enemy, My Ally, when a group of Romulans pretend to take the Enterprise, McCoy and the Romulan ship's doctor work together to tag any items in the food processors that will give the Romulan crew the "Titanian Two-Step."
  • Touched on in Star Wars Legends; though most species apparently have comparable digestive systems, a few unusual species, such as the Gand, enjoy foods that would either be indigestible or outright poisonous to others.
    • In an example from the Jedi Apprentice series, an Arcona, snacking on ammonia crystals, covers his plate when a human (Obi-Wan) reaches for the salt, explaining that sodium chloride is a dangerously addictive drug for his species.
    • According to Tales from the Mos Eisley Cantina, there is apparently only one human bartender on Tatooine, due to the insanely large amount of information about drinks that needs to be memorized so as to not kill customers with the wrong drinks. In another novel Han mentions that the bartender at the bar better not be watering down the drinks, since the species he's serving is allergic to water! Said bartender is also attempting to develop a perfect drink for Jabba. A single drop of the prepared liquor is enough to leave him convulsing on the floor.
    • After Tycho kills a cave creature in the X-Wing Series comics:
      Wes: What's that?
      Tycho: Might be dinner.
      Wes: Are you nuts? What if it's toxic?
      Tycho: Let's cook it and see how it smells.
      • Turns out that it's a ronk. Female ronks are physically nearly identical to males, but their flesh is highly toxic when eaten. Fortunately, Tycho killed a male.
    • Hutts are also apparently indigestible, even to the Sarlacc, but Hutts can seemingly eat anything; in one of the Tales from Jabba's Palace, it's revealed that someone is attempting to poison his food. The problem for the investigators? Over half of what Jabba eats is poisonous to most other species. Another example comes up in The Han Solo Trilogy; when Jabba wants a rival Hutt poisoned, it's tremendously difficult to find anything that will actually work.
    • An aversion comes up as a Noodle Incident in Death Star.
      Ratua: Dinner, when you get off? My place?
      Memah: As long as you promise not to cook.
      Ratua: You wound me, woman.
      Memah: Better than poisoning you, like you nearly did me.
      Ratua: How was I to know your kind can't eat sweetweed?
      Memah: You could have looked it up. You plan to date outside your species, it's on you to know what's poison and what's not.
      Ratua: You're never going to let me forget it, are you?
      Memah: Not a chance, Green-Eyes.
  • Subverted in Terry Pratchett's Strata where an important plot point is that the carnivorous Silver has a different biological makeup that makes it impossible for her to eat meat from a different planet. Being a predator, she will however turn into a ravenous badass killing beast which will still kill everyone in sight if her hunger gets the better of her.
  • A True Story, an Ancient Roman novel by Lucian, has the unbuilt form. Moon people, Sun people (yes, the sun is an inhabited world), and people from various stars all eat quite similar food to humans — milk, cheese, cabbages, onions, etc. Their worlds are also located inside Earth's atmosphere.
  • Averted in David Brin's Uplift novels. A food eaten by one species is likely to trigger an allergic reaction in another. One planet has so thoroughly incorporated heavy metals that dolphins who swim in its oceans need chelation afterward. In GURPS Uplift, a Hoon goes into a delirium when a human child gives him peanut butter.
  • Played both ways in the Vorkosigan Saga by Lois McMaster Bujold. The wildlife on the newly discovered earthlike planet Sergyar is edible, but has to be well cooked because native parasites might find humans edible as well. On the other hand, the native flora of the world of Barrayar is hostile to its human inhabitants. Most of the plant life is some shade of red or brown, is completely inedible (and often poisonous to humans), and produce enough environmental toxins that mutation can be a real problem on the planet. Especially during a centuries-long period of isolation from the galactic community leading to the loss of modern medicine. Barrayarans developed a very Sparta-like attitude towards birth defects and deformities as a result.
  • Specifically mentioned in David Gerrold's The War Against the Chtorr novels: the invading Chtorrans have absolutely no problem chowing down on Earth lifeforms, leading human scientists to speculate that the attackers were deliberately created/bred to be compatible. (Whether this is true or not is yet to be revealed.)
  • Both averted in The Witling by Vernor Vinge. The food on the Earth-like alien planet is biologically compatible with human digestion, but all of it contains heavy metals which will eventually poison a human over a period of weeks to months as they slowly build up to toxic levels in the human body. The (human-like) aliens' bodies can process and excrete the heavy metals naturally.
  • Somewhat touched upon by Harry Turtledove's Worldwar Alternate History series. The Race's biology and biochemistry are similar enough that they can live on Earth and eat some Earth biomatter with no problems. However, what would be slightly chilly to humans is beastly cold to them. Their home planet is basically a large desert with no freestanding oceans, and so hot that ice only exists in laboratories. Less prominently mentioned is that Earth is also a lot wetter than they are used to: Lizards stationed in Earth's tropics are very susceptible to molds and rots. Moreover, household spice ginger is so addictive to them it becomes their version of cocaine. It also triggers "heat" in their females.

    Live Action TV 
  • Alien Nation expands on the differences between human and Newcomer biology. In addition to getting drunk on spoiled milk and burned by salt water, caffeine makes them dizzy, tobacco makes them stutter, and chocolate will give them a heart attack (like dogs). Meanwhile, certain things which are toxic to humans are harmless to them. Methane, alcohol, asbestos, and radon have no effect on them. They even use arsenic flakes as a food seasoning. They cannot absorb nutrition from food which has been cooked, so they eat meat and vegetables raw. As for hybridization, both humans and Newcomers initially think it is impossible, but later grow afraid that given how adaptable the Newcomer genome is, viable hybrids might eventually occur (though none have by the most recent entries in the franchise).
  • Babylon 5 features several examples of characters consuming food from alien societies. Sometimes there's no problem, other times... Well, this is what happens when Centauri try human fast food: "It tastes so good going down. Coming back up, it's not so good." Everybody can (and does) eat spoo. Even pak'ma'ra, who are carrion-eaters with a strict religious-based dietary code.
    • On the other hand, the show at least pointed out at other times that a few species are explicitly not biologically compatible with human standards. A few sections of the station are fitted for exotic atmospheres, particularly the methane-breather section. The Gaim even have to wear space suits all the time when they go to the regular oxygen-rich parts of the station.
    • At one point G'Kar claims that every race has independently created their own version of Swedish Meatballs. According to the card game, even the Vorlons have one and it's apparently a sentient lifeform. Very much Played for Laughs.
    • When Londo Mollari asked what an item a salesman was offering, he said "Candy, only for carbon based life-forms who can metabolize sugar, otherwise it's decorative."
    • Alcohol appears to have exactly the same effects on Centauri that it does on humans - and, it's implied, on Narns and possibly other aliens as well. Well, Narns seem to have an alcohol tolerance maybe twice what is normal for humans (due to their overall robust physiology), so they just drink higher proof booze. On the other hand, Minbari react quite badly to booze and become feverish and homicidally violent. Basically, alcohol is like PCP to Minbari.
    • Unlike Star Trek, cross-species hybrids are difficult if not impossible to create naturally (even though cross-species sex is possible for certain species pairs). First One tech is able to hybridize the adult Delenn, who then has a hybrid baby with Sheridan by virtue of the fact that she is already a hybrid - and even then, their doctors thought her odds of successful conception were negligible. They do consider splicing the telepath gene across species barriers, but the telepath gene was actually spliced into most races by the Vorlons, so it was artificial to begin with.
    • In the novel To Dream In The City Of Sorrows, Sinclair has to drink a certain Minbari beverage as part of the ritual to become Entil'Zha (Head of the Rangers), and is nearly killed by it. The Minbari knew this would happen, which is why that part of the ritual was delayed as long as possible, he only drank one sip, and they had a medical team standing by to treat him the moment the ritual ended.
  • Doctor Who: The Doctor is apparently some kind of super-omnivore, with the exception of aspirin (and presumably other salicylates, like wintergreen Lifesavers) which is very toxic to Gallifreyans. However, the effects can be counteracted by consuming significant amounts of triglycerides (i.e. fat, in one specific case cocoa butter). It gets even worse when the Slitheen (who are calcium-based life) are shown eating regular human food so as to keep up appearance and thus not blow their cover. Must have been a bugger avoiding vinegar all the time, maybe they should've started their campaign by invading France.
  • Food is played with in Farscape. The human Crichton is forced to subsist on food from a far side of the galaxy which has never even heard of humans, so therefore wouldn't be expected to have any idea what a human's body can process. Obviously, any time he has a chance to have food from earth—even if it's all in his own head—he consumes it with relish. Additionally, food cubes are a standard processed food source used by many different species with no noticeable problems - though apparently, the whole idea behind food cubes was to make a standardized, cracker-like foodstuff which was molecularly simple enough that most carbon-based life forms can digest it.
    • On the other hand, even when fried, dentics (shrimp-like creatures that clean teeth and leave a somewhat minty aftertaste) are unpalatable to virtually any species, likely as a defense mechanism to prevent them from being ingested as they do their job. Unpalatable to anyone but Hynerians, at least...
    • Somewhat averted in Season 4, when Crichton's alien companions get to sample earth food. Apparently sugar is a highly-addictive narcotic with crack-like effects on Hynerians. Chiana also tries to eat a tube of lipstick, and justifiably finding it inedible.
    • On the other hand, it is eventually revealed that the Sebaceans (the human like race on that side of the galaxy) actually were originally humans. They were kidnapped from Earth thousands of years ago by a race of Precursors, and slightly genetically modified.
  • A mild aversion in Stargate SG-1. In the Season 4 episode "Small Victories", Sam is taken to the Asgard homeworld to help them defend against the Replicators. When she asks for food, Thor beams in some colored food bits and recommends the yellow one. Carter finds it disgusting. Thor presumably knew she could eat it just fine, but probably didn't take taste buds into account.
  • In Stargate Universe:
    • The crew of the Destiny often harvests foods from alien planets they stop by, simply because they're going to run out of Earth food in a hurry without any way to replenish it. They are, however, shown conducting tests on the food to ensure it is safe for human consumption (most of it tastes terrible regardless). Except for a few Funny Moments when Greer simply decides to take a bite out of alien fruit and is chastised by the medic for possibly poisoning himself.
      • "What are you doing, we don't know if that's poisonous?" Greer (deadpan): "We will."
    • In another case, they try to establish friendly intentions with a new alien by offering it some (Earth) fruit. It hesitantly takes a bite... and begins spitting and coughing in disgust. Fortunately, it and its friends seem to understand that the humans were not deliberately trying to harm them.
  • Star Trek is a flagrant and persistent violator of this one. Humans who like Earth dishes are in a distinct minority. In fact, almost any foodstuff mentioned is prefixed with an alien adjective ("Rigellian cheese", "Centauri trifle") while Klingon food gets its own vocabulary and a legion of human devotees. Practically the entire crew of Deep Space Nine seems to subsist on Raktajino (Klingon coffee). At least some examples may be cases in which Earth-derived foodstuffs are merely prepared using techniques introduced from other worlds.
    • It's subverted in one episode of The Next Generation, where Doctor Pulaski gives herself an injection before drinking some of Worf's tea, and the Klingon tea is also poisonous (though not 100% fatal) to Klingons, as the point of the tea ritual is that "Death is an experience best shared".
    • Most races do not like to eat Klingon food. Of course that isn't because it's inedible, but it's still moving.
    • It was also subverted in one of the paperback novels, where Riker has to go to sickbay after having lunch with Worf and accidentally eating some items which were explicitly listed as indigestible to humans.
    • Episode "The Way To Eden" in TOS averted it. The plant life of Planet Eden was toxic and corrosive.
    • Used as a plot device in one episode, "Allegiance". When Picard and a group of three different aliens are captured for a 'rat in the box' type experiment, one of the aliens cannot eat the food provided. Given that he is a predator of other species and very violent, this becomes a reason to escape.
    • And there was an episode of Enterprise featuring a human crewmember stranded on a hostile planet with an alien. They tried sharing a canteen, which didn't work so well. The alien also had some kind of spittle that could rapidly heal wounds on human skin.
    • Another episode of TNG had Picard and Crusher stranded on an alien planet. Crusher was injured, and had Picard pick a random herb for its medicinal properties, which she could determine because its juices turned his skin yellow, and it tasted bitter (yes, the DOCTOR had Picard taste it before she knew what it was, though she does warn him not to swallow any). This could have been justified as part of her medical training, except she says she knew of it because it was a folk remedy in her native Scotland.
    • Deep Space Nine touched on this at least once. Sisko, annoyed by an assassination attempt made on the station, sits down with Gul Dukat and Weyoun (the official representative of the Dominion) with the bottle of poisoned kanar (Cardassian booze). As Sisko and Dukat argue, Weyoun knocks back a glass of the stuff, and exclaims, "Oh, that is quite toxic, isn't it?" Turns out Vorta are immune to most known poisons. This is probably because the Founders of the Dominion genetically constructed the Vorta from the ground up to be their perfect servants.
    • Averted in Star Trek: Voyager. When Neelix and another person beam down to look for what the ship scans say are edible flora despite slightly harsh atmosphere (only slightly toxic, if a human (or Neelix) are exposed to it for too long could cause a rash and then after about three hours get seriously ill), they instead find nothing. The atmosphere actually also has amino acids and other nutrients in it that the local sentient but primitive live on, and it's slightly toxic to other species.
    • Played amusingly straight in an early episode where a large portion of the crew beams down to a planet to forage for food. One crewman locates what appears to be an apple and is about ready to bite into it before Neelix explains that it's highly toxic and will cause all sorts of unpleasant reactions. This despite the fact that by this point Neelix has known of the existence of humanity for maybe a month and definitely doesn't have the medical knowledge required to know what would happen to human physiology if they ingest the fruit. He then goes on to recommend a less tasty but much more suitable plant instead...
    • In TNG, it was revealed that the transporters have a "biofilter" that is capable of removing pathogens (but to look at it sardonically, it doesnít ever work any time an episode is about bringing a plague onto the ship).
    • Justified in an example that straddles the line between this variation and the alien disease version. In DS9: "Body Parts" Julian has to administer some pretty serious medicines so that Kira, a Bajoran, is able to act as an emergency surrogate mother for Kirayoshi O'Brien. Among other things, he had to drug the fetus so it could accept nutrients from a Bajoran womb.

    Tabletop RPG 
  • Partially justified in Traveller, where the Vilani (a race of Transplanted Humans brought to another planet in ancient times by meddling Precursors) have a culture shaped by the immediate incompatibility with their environment; one of their governing castes grew out of those with the necessary skills to chemically reprocess alien foodstuffs into human-suitable nutrition. One of the disadvantages of this history was that their biotechnology suffered from lack of compatible pathogens, and once they went to war with the Terran Federation many died of disease.
  • Averted in Centauri Knights. The surviving Centaurian ecosystems on the space colonies are home to incompatible foods and creatures, but a biomod is available to change a character over from Earth food to Centauri food permanently, with no mix-and-match. The planet itself has no ecosystem left, as it was wiped clean to the bedrock by nanomachines thousands of years before, and thus humanity is able to begin terraforming it without contamination.
  • In a Played for Laughs subversion, school dietitians in Teenagers from Outer Space react to the arrival of thousands of new and weird alien species in a unique way: they keep serving the same stuff they served all along. After all, it wasn't quite meant for human consumption anyway.
  • Averted in a sourcebook for Werewolf: The Forsaken dealing with werewolf physiology and behavior. The book makes it very clear that becoming all fuzzy when you've got chocolate, caffeine or drugs in your system can mess you up something fierce (as chocolate and caffeine are trouble for canines, and... well, the drugs should be fairly obvious, shouldn't they?).
  • "Alien Wars", a Military SF setting for Star Hero, features the Xenovore race, which can metabolize any meat regardless of which planet it comes from. Sentients are the tastiest, but they'll eat nonsentients if that's what's available.
  • The number of half-X, half-Y creatures in Dungeons & Dragons borders on mind-boggling. Depending on the edition and setting, you could encounter a half-elf, half-orc, half-dragon, half-demon, half-devil, half-angel, half-robotic-thingy, half-undead, half-eldritch abomination, half-god, half-halfling, half-giant, half-fey, half-chaos frog thing, half-elemental, half-djinn, half-dwarf, half-furry, half-golem, half-mutated egg-laying cousin of humanity, half...oh, you get the idea. Most of them can eat and drink the same things (if they do indeed eat and drink.) And the idea of the act bringing some of these creatures into existence ranges from hilarious (half-giant) to pure Squick. Sometimes, a Wizard really did it, and how!
  • Justified in Myriad Song where the Syndics usually didn't bother with enslaving species that couldn't survive on the same food and air as most of their slaves. The most notable exception being the silicon-based Towsers, who can still breathe oxygen (and carbon monoxide) but need to eat polysiloxanes.
  • Bleak World not only can the Alien Race eat human food, the occupation team is better at preparing red meat than most humans are.

    Video Games 
  • Played straight in Borderlands. The occasional spit-roasted Skag seen at raider camps can be handwaved as the ill-educated locales (i.e. Rednecks) not knowing any better, but then you find that there is industry devoted to producing canned Skag meat which is quite popular. Also, T.K. Baha grew bladeflowers on his farm. They seem to be somewhat popular with the ladies there, suggesting the pollen of the plants is no worse than that of Earth plants.
  • Played straight with the Mothership Zeta DLC of Fallout 3. Throughout the exploration of the titular alien spaceship the Lone Wanderer finds numerous alien delicacies like squids and worms that when consumed restore your health with no obvious side effects. The alien equivalent to Stimpacks heal you just as well, but have the occasional side effect. Though the game in general does function on what people of the 1950s thought a world after nuclear war would be like, so it is most likely also showing what people from that era thought aliens would be like.
  • In one event FTL: Faster Than Light, you are offered to share a drink with a captain of another ship. It's a 50/50 chance that it is just wine, or poison. However, if you have a rock crew-member, who are immune to just about any poison imaginable, you can send it to have the drink and be the "captain" in your stead.
  • Halo often plays this pretty straight:
    • The Hunters in particular are capable of eating basically anything that exists (though they seem to prefer metal).
    • Additionally, several Covenant species are capable of eating other species (including humans) with no ill effects. Brutes especially consider humans very nice eating (at a Nightmare Fuel extent), and Grunts, Jackals, and Drones will happily chow down on POWs and KIAs of almost any species. Heck, Grunts will occasionally advise "If hungry, eat Jackal", and one point in Halo 2 has two Brutes wondering why they're not allowed to eat their Elite prisoner.
    • In Halo: Glasslands, the first human to visit Sanghelios (the Elite homeworld) is served Sangheili food with no problem, although the, um, texture isn't very appetizing ("Who ate that before you?").
    • According to The Forerunner Saga, the Forerunners can safely eat Earth-based food as well. Though it is mentioned that they cannot catch human-based diseases.
    • The reveal that a species known as the Precursors was largely responsible for seeding the Milky Way with intelligent life might go some way to explain all this.
  • Averted in Mass Effect:
    • Turian, quarian and volus biology is such that they cannot eat the same food as most other species. Turians and quarians both require dextro-amino acids in their proteins and can't derive nutrients from levo-foods, and at best the food will pass right through, providing no nutrients, as opposed to humans, salarians and asari, who all use levo-amino acids. Volus, meanwhile, have an ammonia-based biochemistry, which is utterly incompatible with everyone else's.
    • A human in the Expanded Universe got sick off alien food designed to resemble earth origin food. Whether this is due to biochemical barriers, or a lack of competence on the aliens' part is unclear.
    • In the sequel, there's a romance path for either a turian or a quarian, depending on PC gender. In the case of the quarian Tali, she actually contracts a mild allergic reaction to the male PC (but it was completely Worth It in her opinion), while with the turian Garrus, a female PC is cautioned by the ship's doctor not to... ingest.
    • Also in said sequel, one mission involves a group of Alliance soldiers that crashed on a planet and started eating the local plant and animal life. The food caused gradually increasing neurological damage in those who consumed it.
    • Likewise, Grunt claims that the krogan equivalent of alcoholic beverages goes through humans "like broken glass". Shepard can survive having a krogan drink in one of the hub-world bars, but then (s)he isn't 100% human anymore. It's also fairly understandable why this is the case; the krogans have evolved to the point that only a few very strong chemicals can likely affect their biochemistry, and dextro-proteins can still wreak havoc on their systems — the asari bartender of Eternity on Illium casually mentions that, about 600 to 700 years ago, she saw a krogan drink liquefied turian (that is, a turian that had been blended into liquid) for a bet. In her words, "nobody came out of that one looking pretty". She also warns against the red nuts, as they are for turians and quarians, and will only give humans cramps.
    • In a conversation between a turian salesman and human customer at a restaurant, the turian explains to the human (and not for the first time, judging by the tone of voice) that mixing spices of the wrong chirality can kill him if he eats it.
    • There's cut content in which the turian Citadel groundskeeper explains that turians haven't created many intoxicants, and is amazed by human ingenuity in brewing.
    • Some content even goes into hanar intoxicants: since they can't get drunk (being 90% water jellyfish creatures, dehydration is kind of a bad thing for them), they eat "mindfish", which are mildly hallucinogenic. Shepard asks what the effect of mindfish is on humans, and gets the reply: "Much more potent. Also releases into our systems very slowly, so best to clear your entire weekend first."
    • Lampshaded in the Citadel DLC if Javik is brought to the casino. He'll try to distract the guard by complaining that the beverages are toxic to Protheans. The guard wearily replies that everything they serve is toxic to someone, and guests should be vigilant while selecting their drinks.
  • Pikmin: In the second game, Olimar discusses the possibility of bringing back the giant fruits and vegetables he finds for use as food on Hocotate, but he also notes that he's not a biologist, so he's unable to test for health effects. Louie also eats most of the native fauna (including one explicitly described as "inedible"). In the third game, the Koppaites can eat fruit found on PNF-404 without any trouble. However, it is noted that they searched practically the entire galaxy for planets with food safe for them to eat, and PNF-404 is the only one they found.
  • Justified in Sid Meierís Alpha Centauri, where you have to research the appropriate technologies in order to harvest resources from xenofungus squares. This quote from an in-game character sums it up:
    Deirdre: Juicy ripe grenade fruits may look appealing, but a mouthful of highly toxic organonitrates will certainly change your mind in a hurry.
    • Furthermore, although it's mostly All There in the Manual, it's explicitly stated that although terrestrial plants take to Chiron like flies to honey (or perhaps more precisely vinegar) humans must wear oxygen masks and filter their water with ozone lest they die of nitrogen narcosis.
    • Played completely straight, however, in its Spiritual Successor Civilization: Beyond Earth, where you can immediately farm the native flora and fauna, as well as grow terrestrial plants with ease.
  • Starbound: Taken to the point where plants of Glitch (who are a race of robots) are edible by all races, despite having clearly shown metal cover.
  • Startopia: Used and averted; all aliens breathe the same air without complaint and synthetic food can be eaten by all species. However, some species will find certain biodeck environments highly unpleasant and specialist food can cause problems if eaten by some species. There are also diseases that can be caught by any of the aliens races, but hit some races harder than others, meaning the disease in question can be a debilitating or a simple sniffle.
  • Used in Sword of the Stars: Humans, tarka and hivers can all eat each others' foodstuffs with no ill effects (though non-hivers find hiver food terribly bland). Hiver biochemistry and taste organs are wired such that human spices and fermented goods (such as cheese) are near-narcotic to them (on the other hand, they have no reaction whatsoever to ethanol), and hiver warriors apparently eat garlic as a form of manhood test because the taste sensation makes it actually dangerous to them. Zuul are able to eat everything (or anyone) without any bad side effects, though being genetically modified this may be justified.
  • Xenoblade Chronicles X: None of the various alien races seem to have a problem with human food, except the Zaruboggans, who consume toxic waste for sustenance (and humanity produces plenty of that to fulfill their dietary needs). Especially obvious with the Ma-non, who become absolutely obsessed with pizza, to the point that they will accept payment for their ludicrously advanced technology in the form of a few pizzas. This hilarity gets much darker when, late in the game, the wife of the owner of a pizza restaurant commit suicide because of the stress of fulfilling the Ma-non's endless requests for more pizza, causing her husband to go on a psychotic Ma-non killing spree.
  • In the X-Universe, a tofu-like substance called BoFu makes up a large portion of the Boron diet. The squids love the stuff and can live on a nugget of it for a week, but the other races can't eat it.

    Web Comics 
  • Averted with a vengeance in Digger, when the eponymous wombat (a strict herbivore) is forced to attend and participate in a Hyena funeral (the hyenas practice funerary cannibalism). She gets very ill, and the hyena healer has to administer a purgative medicine and sneak her out to save face.
    • Also played for laughs with Ed's warrior tea, which is meant to strengthen the... territorial scent markings... of a female hyena, to establish herself as a fearless warrior who goes where she pleases. Digger is not a hyena, does not plan to stay in the area, doesn't use urine to mark her territory, and can't stand the taste, but drinks the tea to be polite.
  • In Freefall, the incompatibility of amino acids on Pfouts with terran biochemistry was the reason for Dr. Bowman's experiments with uplifting nonsapient species, in lieu of very expensive space travel and terraforming. The Bowman's Wolf (including Florence) was to be a "proof of concept" test.
    • Played with in regards to Sam's biochemestry; since he comes from a planet with a relatively benign climate that forced few selection-pressures on his species and lacked anything like the asteroid strike believed to kill off dinosaurs on Earth, his protein structure is surprisingly simple, and delicious to most Terran animals.
      • Counterwise, Sam can seem to eat most stuff humans can, and quite a lot else that may be poisonous to humans.
  • The huge and scary People-Eating Poly-Sorbate Insectoid in The Inexplicable Adventures of Bob! is perfectly capable of swallowing a man-sized creature whole, but cannot digest Earth life. Hence, a swallowed character can punch the critter's stomach lining until he is... forcefully regurgitated.
  • At first appears to be the case in Mare Internum, when some kind of Martian fungus attaches itself to Mike, presumably "eating" him. Later justified when we find out that Earth life evolved from Martian waste.
  • Saturday Morning Breakfast Cereal: Discussed in this comic. Where The Smart Guy actually points out that they wouldn't be nutritious nor tasty.
  • Generally present Schlock Mercenary - common food is freely edible by many different species. Averted on a specific occasion here, when a sea monster, being composed of highly toxic materials and nanobots, proves to be utterly unsuitable for consumption by anyone except Sergeant Schlock. Schlock himself is a carbosilicate artificial lifeform that is capable of digesting pretty much anything. His reaction to aggressive electroplating nanobots in the sea monster is that he admires food that fights back and likes the fizz.
  • Discussed in Spacetrawler when Dimitri visits an alien bakery, and handwaved with the approxiscan, a device which can identify compatible substances for one's biochemistry. In fact, Dimitri sells the aliens his grandmother's cookie recipe, which becomes insanely popular.

    Web Original 
  • Averted in Pay Me, Bug!, at least as far as getting drunk goes. One species' intoxicant is another's deadly poison, so you need to have your wits about you when drinking with others, or you could accidentally grab a bottle of poison. Of course, if you're drunk, that's precisely the time you don't have your wits about you.
  • Averted in Nemo Ramjet's Snaiad. Snaiad life has right handed amino acids in its proteins, compared to left handed ones in humans. This makes Snaiad life almost indigestible to humans (with the exception of the energy one could get from breaking down sugars and what not). This also goes for the native Snaiadi wildlife, who quickly found out that humans weren't tasty.

    Western Animation 
  • Played straight in the 3-2-1 Penguins! episode, "Give and Let Give". Kevin manages to gulp down a whole chocolate cupcake Michelle baked without suffering any ill effects from the theobromine.
  • Averted in Ben 10. Ben feeds an alien chocolate, and nearly kills him in the process. This particular alien was a pastiche of Superman, thus making chocolate his kryptonite and only ate it because Ben offered, and he didn't want to seem rude (though neither of them seemed to KNOW that this would happen). There's also Upchuck, who can't eat human food, but CAN eat absolutely everything else.
  • Played straight AND averted in The Fairly OddParents!, depending on the episode and substance in question. Mark Chang has been shown able to consume human vegetables and (on one occasion) feces (with Cow Manure apparently being the most delicious), but any type of candy is caustic enough to melt through his flesh (well, not his, but one of his buddies from the same race, so we can assume the same could happen to him). Also, while it's not shown, it's stated that hugging cute fuzzy stuff or prancing through a field of flowers can cause their skin to bleed and/or catch fire.
  • Averted in Invader Zim. Water is caustic to the eponymous alien, and meat actually fuses to his flesh. He does attempt to build up a tolerance, but GIR, being a robot, can (and does) eat anything. There was one Earth food Zim discovered he could eat (to his own surprise) in the episode "Zim Eats Waffles", except the ones made by GIR because he put peanuts and soap in them.
    "GIR, your waffles have sickened me! Fetch me the bucket!"
  • Star Wars: The Clone Wars: Zigzagged in "Senate Murders" — the first murder is committed by spiking a bottle of liquor, drunk by multiple people of multiple species, with a species-specific poison.

    Real Life 
  • Caffeine. To us, a mild stimulant. To a bug, a deadly poison of doom. Nicotine is somewhat similar - long-term use may not be particularly good for you, but it kills insects very quickly.
    • Even among mammals, you run into problems. Chocolate chip cookies with macadamia nuts and raisins are a rather easy thing for humans to eat, but to a dog the chocolate will cause potentially fatal arrhythmia and raisins are essentially kidney failure pills, while the macadamia nuts are a powerful paralytic. Some humans don't like onions and/or garlic, but most canines and felines will have their red blood cells dissolve if they eat enough.
    • Nor is it only a problem from one species to another. Cow milk is usually tasty to individuals of Western European stock, but Chinese or Thai groups have an impressive predisposition to lactose intolerance, since after infancy it is the default. It seems that only people from cultures where people traditionally drink milk from cows or other animals are lactose tolerant, since it apparently evolved when we started domesticating animals and taking their milk for ourselves, as being able to properly process the stuff even in adulthood would then have been beneficial. Since fermenting milk into cheese or yogurt destroys most of the lactose, people who are lactose intolerant can generally digest those foods much better than they can raw milk. This is why anybody bothered milking farm animals in the first place.
      • Some anthropologists believe that this is why the Native Americans turned against Leif Ericson's expedition to North America in 1066. The natives gave the explorers an offering of food, to which Ericson's group responded with an offering of their own — fresh milk from the goats they had brought with them. Unfortunately, the lactose-intolerant natives grew ill from the milk, and decided that Ericson had tried to poison them!
    • Similar patterns apply for alcohol. To ensure that water was safe for human consumption, early civilizations fell into one of two camps: those who boiled their water (primarily Asia, where dried leaves were added for flavour and was the origin of tea drinking) and those who fermented either juice or sweetened water, creating wines, beers, and mead. (It's not strictly the alcohol: the fermentation itself kills off pathogens, as the quickly dividing yeast absorbs all the food and starves them.) To this day people of European descent have a generally higher alcohol tolerance than Asians do, and among Europeans cultures that discouraged alcohol drinking will have less tolerance.
    • Also, brewing beer involves using boiling water to leach the sugars necessary for fermentation from the malt. In the same way for making mead, honey dissolves a LOT faster in boiling water, and if any pathogenic lifeform DOES contaminate the fermentation process, it is usually VERY easy to detect it in the product, adding another layer of protection. Honey itself is known to kill bacteria.
    • Pure nicotine applied to the skin will kill any mammal, humans included, in seconds. And caffeine becomes lethal past a certain level of blood content. It's not a matter of biochemical barriers; it's a matter of scale. A study by NASA of all people shows the results of caffeine, marijuana, Benzedrine (speed), and choloral hydrates (sleeping pills) on a spiders ability to make a web.
      • Hilariously spoofed here.
  • This works the other way as well. Death's cap mushrooms are, as the name suggests, potentially lethal (hello, liver transplant!) to humans, but are commonly eaten by other animals, especially deer. In fact, more than one person has died from eating death's cap after assuming it was safe because he saw some other animal eating it.
    • Oh, and they taste good, too. Death caps (Amanita phalloides), and the destroying angel (Amanita verna) have been used for assassinations because their good taste and harmless appearance conceal deadly amanitatoxins, which destroy the liver. First symptoms of acute liver failure appear 6-8 hours after poisoning, giving the assassin plenty of time to slip out unnoticed before the victim even realizes he's been poisoned.
  • Peppers are hot because they are filled with a chemical called capsaicin (or methyl vanillyl nonenamide, if you really must sound impressive). This chemical is toxic to most small mammals, but not to birds, which also cannot taste it and to some extent acts as an anesthetic. The seeds, likewise, can pass through bird digestive systems, but are rendered non-viable by mammals. The capsaicin, thus, serves by its burning sensation to prevent mammals from eating it, leaving the flesh for the birds which help spread the seeds. Humans are large enough that it doesn't normally kill or poison them, but most animals don't actively seek out food that burns their mouths...although on the other hand, the fact that humans do seek out food that burns their mouths can be seen as a victory for the pepper plants' strategy, since the human love of spicy food has resulted in the spread of the peppers far and wide around the world and all but guaranteed the survival of the species that humans have cultivated.
    • Dimethyl anthranilate, which is used as the principal artificial flavoring in grape soda, has the same biochemical effect on birds that capsaicin has on humans.
    • And the reason humans originally got to like spicy things was because they didn't spoil as readily, since capsaicinoids repel fungi.
  • Some avocados are toxic to some birds, and most other animals native to the regions in which they grow. It is hypothesized that the fruits evolved to be eaten by giant ground sloths which are now extinct, which would spread the seeds in their droppings. Nowadays guacamole-hungry humans and their knowledge of agriculture serve the same purpose.
  • Sales of royal jelly, a nutrient-rich secretion which bees feed to their larvae, mostly hinge upon buyers' belief that one of the effects of this substance on bee larvae designated as future queens - specifically, a greatly-extended lifespan - will transfer over to humans if ingested or applied topically. It's not toxic in this case, just useless due to extreme physiological differences between bees and people.
  • There's at least one genus of plant that stores up its energy as a carbohydrate that exists nowhere else in nature, rather than as starch. So far as is known, nothing can utilize this storage-molecule except the plant itself, so no herbivore bothers to try to eat it.
  • Played straight in the story of the Ghost Dance, wherein people dreamed of visiting the moon and eating animals from the moon.
  • There are very very few life forms on Earth that are able to digest plastics. This is why our garbage is expected to last for millions of years before it decomposes, and to leave behind toxic chemicals when it does. Recent observations of the North Pacific Gyre suggest that we're providing enough food to allow the few we do have to start to thrive.

Cross-Species Disease

    Anime and Manga 
  • Brought up and then averted in an approved doujin sidestory to Dance in the Vampire Bund. Not only are vampires immune to all human diseases (Except for tooth decay, which isn't communicable), some vampires actively seek out the blood of the ill, as the disease changes the flavor.
  • In Dragon Ball Z, Goku apparently contracts a disease while on the planet Yardrat, weakening his heart and which would have eventually killed him. He's saved by a vaccine brought over from an alternate future where he did die. While Goku is an alien himself, the Saiyan biochemistry is identical to a human being's as far as nutrition and reproduction are concerned.
  • Higurashi: When They Cry: It is speculated that the parasite behind the Hinamizawa Syndrome actually came from another planet. Then again the person who said that is also the one who wanted to turn it into a bio-weapon, so it's questionable how trustworthy this is.
  • The V-Type Infection from Macross Frontier, which comes from bacteria that live in Vajra, and is lethal to humans and Zentraedi (though it takes a few years to actually kill someone). Ranka Lee is the only known person to have been infected and survived; indeed, she's completely immune to it, speculated to be because she contracted the disease when still in her mother's womb. It turns out that the bacteria are the mechanism that allows the Vajra's Hive Mind, and the human/Zentraedi infections were the Vajra's attempt to communicate with them. The problem is that in most infections, the bacteria went for the host's brain, and caused lethal damage. The bacteria in Ranka settled in her intestines, where they achieved symbiosis. Once the Vajra figure this out at the end of the series, it is implied they are able to influence the bacteria in other infections to do the same, preventing any further deaths.
  • Mobile Suit Crossbone Gundam: Ghost has an alien microbe that the villains plan on releasing on Earth, which the heros are trying to prevent. The logic is that since the microbe has a completely alien biochemistry, nothing on Earth will be able to defend against it, and it will spread like wildfire and wipe out any life it comes across. This ignores the fact that the opposite should be equally as true: the microbe should be just as defenseless against Earth's microorganisms. Or, in the most likely case, absolutely nothing happens, and the alien microbe dies due to lack of its native environment.
  • Taken Up to Eleven in episode 4 of Space Dandy, with a zombie virus that infects every single species in the galaxy, including humans, all kinds of aliens and robots.

    Comic Books 

    Fan Works 
  • "Solaere ssiun Hnaifv'daenn": Because bloodfire already managed to jump species once before (in the TNG novel Death in Winter, from Kevratans to Romulans), Doctor Emira t'Vraehn gives the human Jaleh Khoroushi a dose of the vaccine, just to make sure the disease doesn't develop a taste for humans next.

  • The Facehuggers in the Alien films are somehow able to impregnate species (like humans and dogs) that would not have been encountered in the environment in which they evolved or by the species that engineered them (the backstory is unclear on which is the case) as long as it is warm-blooded and alive. This is unsatisfactorily explained by claiming that it is capable of adapting itself to the DNA of the host and incorporate features of said host into the Chestburster it produces, but this does not account for how it is able to do so with a completely unknown species with a vastly different biology. If we suppose it was engineered rather than evolved, it seems likely that its creators would have designed it to target a specific species, because making it so adaptable that it could infest completely unknown species would surely mean that it could adapt to infest the species that created them. (Which, according to some sources, is exactly what happened...) As far as in-movie canon goes, Alien: Resurrection makes it clear that the Alien and host's DNA are somehow mingled, even in the host's own blood. That's still crazy from a biochemistry point-of-view (why would aliens even have DNA?), but at least they try to explain it.
    • Somewhat justified by a suggestion that the Xenomorphs were created as either a bioweapon or a terraforming construct (which is the same thing, when you come down to it). Step 1 of any biosphere replacement is going to be getting rid of the existing biosphere, and my aren't these efficient at slaughtering things... This idea presupposes that a simple, but non-obvious, kill switch exists in the Xenomorph biology allowing some easy-to-handle chemical to kill them all. Now imagine a strain that mutates so that it doesn't WORK any more...
    • Ripley in A:R was only the latest, successful attempt at cloning a human/Xenomorph hybrid. There's the memorable (and oft-referenced) scene where she burns the whole laboratory containing her failed predecessors after one of them begs for a Mercy Kill.
  • The alien organism depicted in The Thing (1982), and its prequel, is a single-celled life form, capable of invading the body of any terrestrial animal (including humans), and taking over that animal cell by cell, until it has perfectly imitated the animal. This includes all knowledge that animal had, allowing an imitated person to perfectly pass as that person indefinitely, as well as pass as any animal, integrating seamlessly into, say, a group of dogs. This concept takes this trope Up to Eleven.

  • In one Animorphs book, Ax catches a disease. All of the human Animorphs but Cassie come down with apparently the same disease, which manifests as the flu in humans (though it's much more potentially fatal to Ax.) Worse, the disease seems to affect everyone even in morph, including Tobias, who spends very little time in human form. Having morphing powers seems to be what made them susceptible: no other humans caught it.
  • In Arthur C. Clarke's Before Eden, astronauts discover lithovore slime-like life on Venus... only to wipe it out by inadvertently introducing pathogenic microorganisms from Earth.
  • Averted in the Corean Chronicles for good reason. Virtually all of the native fauna and flora were less animals and plants than rocks and gas interwoven with energy; the necessary jump from silicon- to carbon-based lifeforms or vice versa would be a major barrier.
  • In Robert Zubrin's First Landing, lots of people on Earth start worrying about this after the protagonists announce their discovery of microscopic Martian life. One of the astronauts radios a response back, giving the exact reason why it wouldn't happen — not coincidentally, she almost word-for-word quotes Zubrin's earlier nonfiction The Case for Mars. (The novel was mainly meant to promote the ideas in TCfM.)
  • Averted in The Flight Engineer between humans and Fibians, though the human characters do check to make sure before meeting with the Fibian central government.
  • Honor Harrington:
    • This is part of the backstory for Manticore — a few years after the colonists arrived, one of the local microbes crossed the species barrier and killed a substantial portion of the colonists. Somewhat justified in that one of the things that made Manticore inviting to colonize was how similar its biochemistry was to Earth's. In fact, per the Back Story, the same plague devastated the population of three worlds and their space forces several times.
    • The capital planet of the Anderman Empire had a native microbe that was harmless to humans but ate chlorophyll. The colony was slowly starving because of crop failures, when super-rich mercenary commander Gustav Anderman came along and paid for the expensive genetic engineering to make resistant plants, in exchange for being made emperor.
    • The planet Grayson is a Death World full of heavy metals which forces them to do all their agriculture either under protective domes or on orbital farms. Also humans from different planets have different tolerances. The heroine has to be careful about Grayson foods since even the ones grown in protective domes can have more heavy metals than she can handle while at least one Grayson is allergic to squash from her homeworld.
    • Hades/Hell is effective as a prison planet exactly because its wildlife couldn't be eaten by humans and the vegetation is eventually fatal, so inmates are completely dependent upon their wardens. Camps that misbehave have their food supplies cut off.
  • Avoided in Larry Niven's Known Space short story "Madness Has its Place". When the protagonists begin preparing for combating the incoming Kzinti, biological, chemical, and nuclear weapons are suggested. The main character promptly strikes down the first one; there was no guarantee that a bio-weapon that worked against humans would work against eight-foot tall war cats (if anything, they should capture some of their biologicals).
    • Also averted in the Ringworld books, in which inter-species sex (called rishathra) is common, and it is explained that STDs aren't an issue. Disease transmission would be a little more plausible in this case than in most of the other examples, because the humanoid inhabitants of the Ringworld are all distantly related to each other, and to Earthlings as well.
    • Apparently nobody had told Niven that new diseases could evolve from common soil bacteria, when he first introduced rishathra to the Ringworld's cultures. Until The Ringworld Throne, he'd claimed the Pak simply didn't put any pathogens there, V.D. included.
  • In David Starr, Space Ranger, a series of poisonings occurs in people who ate Mars grown food. A (human) Martian scientist says it could have been a poisoning by the local bacteria. Subverted later, when it turns out he was the Big Bad and was telling a deliberate lie.
  • Averted in James White's Sector General book series about an interstellar hospital. (This was someone who would Hand Wave most sci-fi technologies, but think long and hard about how to perform CPR on a six-foot-long, silver-furred, sentient caterpillar. note ) A basic principle of the entire station is that a doctor cannot be infected by exposure to patients of another species. The staff nevertheless remains jumpy at the thought of what a cross-species pathogen could cause if one was some day found. In one book, The Galatic Gourmet the possibility that a cross-species pathogen has not only turned up but gotten loose in the hospital is a large part of the plot. It wasn't. It was food poisoning from a misunderstood recipe.
  • Not exactly a disease, but in Silent Dances the main character avoids getting bug bites on the alien planet because the bugs can't handle her alien chemistry. On the other hand, she has no trouble eating most of the plants and animals on that planet for food...
  • In the Speaker for the Dead trilogy the humans and their crops are infected by a virus, the Descolada, on the alien planet. This trope is averted by the facts that the Descolada was engineered to specifically be able to adapt to different genetic codes, and that the virus may be semi-intelligent itself.
  • Star Trek Expanded Universe:
    • One series deals with a plot to infect all Alpha Quadrant species with 100%-mortality diseases. The first book in the series presents a virus that specifically infects characters of mixed heritage.
    • In Death in Winter, the first book in the Star Trek: The Next Generation Relaunch, bloodfire manages to jump species from Kevratans to Romulans.
  • Star Wars Legends:
    • In The Krytos Trap, an Imperial scientists engineers a biological weapon (the Krytos Virus) that affects many sentient species other than humans. At least partially justified — it's shown as a difficult task, requiring time and ingenuity, and he mostly targets species groups that apparently share a common origin. The disease is quite horrific, but the same adaptability that let it spread to other species also means that it quickly becomes less lethal.
    • In New Jedi Order, an engineered bioweapon is developed for use against the Yuuzhan Vong, who are extra-galactic—there are significant amounts of DNA they have that no known organism in the galaxy far, far away does.
    • Naturally, this comes up often in the MedStar Duology, a pair of Star Wars novels that serve as a medical drama.
      • Bacta seems to work on anything, but other medicines and treatments vary from species to species.
        Jos: Giving a Devaronian two cc's of plethyl nitrate will cure a lobar pneumonia and open up his congested lungs with virtually no side effects. Give that same dose to a human and it'll drop his blood pressure into the syncope zone. Give it to a Bothan—
        Bariss: And he'll be dead before he hits the floor.
      • Bota, called "an adaptogen that can cure anything but a rainy day," does something different for every species, acting as anything from medicine to a nutrient to an incredibly potent drug, and briefly raises Force-sensitives into something very like godhood. The Republic and the Separatists are fighting a pitched and prolonged battle across an otherwise useless backwater world for the sake of the stuff. Everything on that planet is said to have similar mutagenic power, but mostly what it does is make people sick. By the end of the duology, bota has mutated itself into uselessness.
    • In Galaxy of Fear: The Planet Plague, there's a medical research station in an outpost on Gobindi, which is covered in ruins left by a now-lost civilization which studied diseases extensively. It also has a Blob Monster infestation, and said monsters can infect humans and turn them into blobs. It's found that the Imperials found a virus native to Gobindi, have been modifying it, and are now turning it loose on the outpost, looking to find out which species besides humans are affected. It's also darkly hinted in The Stinger that the native Gobindians were killed by some disease even they couldn't handle and the Big Bad has a sample, but this isn't followed up on, so it probably didn't work.
  • The Vorkosigan Saga again: the notorious and disgusting worm plague of Sergyar. "It wasn't all that lethal, as plagues go."
  • In H. G. Wells' original The War of the Worlds the Martians are killed off by a terrestrial microbe within several weeks of their arrival. This is almost a reversal of the trope, as it's rather explicitly stated that the aliens are more vulnerable to Earth microbes than humans, due to not having evolved and adapted alongside them; this is based upon the outbreaks that can occur when two previously isolated human cultures begin interacting and exchanging diseases, unintentionally or otherwise. This is because Science Marches On; the very idea of viral transmittance was new when the book was first written.
    • The War of the Worlds manages to hit the trifecta on this. In addition to the above virus example, the Martians are also capable of breathing Earth's atmosphere (to say nothing of the pressure. The only effect is that the higher concentration of oxygen invigorates them!) and "feed" (having "given up their digestive systems") by injecting themselves with human blood. Oh how science has marched on.
    • It's also mentioned that obviously, Earth's gravity is higher than on Mars, and this slightly affects them: Wells's Martians are basically blobby heads with many tentacles attached (looking sort of like an octopus). They evolved alongside their advanced technology to the point that all of their other organs atrophied except for the brain and "hands" (which turned into tentacles). The narrator mentions that it is believed that on Mars, the Martians actually walked around on their tentacles, like spiders. In Earth's higher gravity, however, it uses up all of their strength just to push themselves around. The problem, of course, is that they don't need to be able to move much to pilot their robotic vehicles, which are militarily far superior to anything the humans can throw at them.
    • Possibly averted in explaining why the Martians did not do to us as was done unto them: "Either there are no bacteria on Mars, or else Martian science eliminated them long ago." Wells allowed for the possibility that the Martians had created - and by extension adapted to - a germ-free environment and thus left themselves vulnerable to essentially everything. Earthly bacteria are amazingly resilient and resourceful under evolutionary pressure; it's hard not to imagine them finding something about a Martian they could get their flagella into.

    Live Action TV 
  • Played with in the Agents of S.H.I.E.L.D. episode "FZZT". A Chitauri helmet infects some firemen and Jemma with an alien virus that makes an electric burst blow a hole in people's heads. However, they figure out that the Chitauri itself was immune to the virus, and was just a carrier. It's even theorized to be the Chitauri equivalent of a cold.
  • Babylon 5 had the Markab people fall victim to a universally fatal plague to which humans turned out to be completely immune, as it acted on a type of nerve cell that humans don't have. The Pak'ma'ra, however, turned out to be similar enough that it also affected them, though less severely. In fact, that similarity allowed Dr Franklin to figure out how to cure the disease - too late to save the Markab from apparent extinction.
  • Averted in an episode of Battlestar Galactica. The fleet stumbles across a Cylon basestar where all the Cylons on board are either dead or dying. It turns out that they've contracted a disease that humans became immune to millennia before due to a probe from an Earth that had been populated by Cylons (the Thirteenth Tribe of Kobol). So in reality they contracted it from an earlier form of themselves.
    • Unfortunately played straight when the fleet reaches a second planet they dub Earth. Yes, it's our Earth, and humans have magically evolved there too. However, that's the least of the problems both scientific and dramatic with the finale...
  • In Battlestar Galactica (1978), two Viper pilots pick up an alien disease on a mission, and skip decontamination to make it to a bachelor party. The resulting disease ravages the fleet. How, exactly, they picked up an alien disease on an apparently lifeless moon, well. . .
  • Doctor Who:
    • "The Hungry Earth"/"Cold Blood": A human is stung by the venomous tongue of a Silurian warrior, and begins to mutate. This trope is simultaneously played straight (it does affect him), subverted (the Silurian doesn't understand why he doesn't just die) and partially justified (Silurians and humans are both technically earthlings; they are just separated by millions of years of evolution).
    • "The Girl Who Waited" plays with this; the "One Day Plague" only affects species with two hearts, so Time Lords and Apalapucians are at risk but humans are fine. Also, when Amy is trapped in a quarantine facility, the Doctor instructs her not to accept any medicine from the robotic staff; they can't comprehend that she's a different species to the rest of the inhabitants and any medicine they give her would be lethal.
    • The Doctor himself has repeatedly had to fend off human doctors' attempts to treat him with human-specific medications, which would be harmful or at least ineffectual to him.
  • Mighty Morphin' Power Rangers: In the opening three-parter of the third season, the Repellator is briefly afflicted with Kimberly's cold after she sneezes on him a couple times. Lord Zedd's reaction is hilarious.
  • Space: Above and Beyond. Having captured an alien prisoner, the protagonists wonder what to feed it. They decide that water is safe enough. The alien promptly dies (though it may have committed suicide rather than remain a captive).
  • Stargate SG-1:
    • In one episode, the local alien population of a planet are falling ill after the arrival of the main team. As the good guys desperately try to find a cure, General Hammond points out that they're lucky they mostly deal with human civilizations who have the same diseases as Earth do and that's it's a small miracle they haven't run into a problem like this before. The episode was ultimately an aversion, since it turned out that the illness wasn't caused by a disease.
    • The Goa'uld are a race of parasitic worms that evolved on some distant planet, but seem to be capable of infecting every sentient race they come into contact with, without any discernible difficulty. They supposedly need to acquire the genetic code from a species they're going to infest and apparently do this via sex, which is...odd, at least the first time. (This was retconned, as the episode in question was uniformly hated by the writers.) Also, the Jaffa were initially created to allow larval Goa'uld time to adjust to human hosts. (Prior to the Jaffa, many more Goa'uld died of rejection sickness.) The Goa'uld still can't parasitize some species, such as the Reetou. It's also explicitly noted a couple times that some species or human populations are resistant or immune to Goa'uld infestation, but the Goa'uld make a habit of wiping them out.
  • Star Trek:
    • Possibly justified by the fact that, as per TNG: "The Chase," most if not all of the galaxy's humanoid species share a common ancestry. It's still weird given the physiological differences (take the Vulcan/Romulan species, which has copper-based blood).
    • Star Trek: Enterprise had an episode where a disease that was apparently a universal infector was used as a sociology experiment by an alien race that had surpassed physical existence — they wanted to see what cultures would do if infected by an incurable airborne alien virus that killed quickly.
    • The novel Uhura's Song was all about finding the cure for an epidemic striking both humans and the catlike Eeiauoans, complicated (among other factors) by the fact that nobody on the planet that should hold the solution recognized its symptoms.
    • The Star Trek: The Original Series novel The IDIC Epidemic concerned a highly virulent and rapidly mutating disease that infected everyone living on a mixed-species treaty world. Originally a Klingon disease, it would affect everyone with similar blood chemistry (iron-based, copper-based, silicon-based), and leap from one blood chemistry to another via mixed-species children. In the end, Romulans (copper-based blood) were immune, and the Klingons (iron-based blood) had an ample supply of the cure, and mass inoculations saved the day.
    • In Star Trek: Voyager the Phage, the disease afflicting the Vidiians, is quite capable of jumping the species barrier (to the point where replacing the afflicted organs with ones harvested from non-Vidiians only slows it down), though Klingon immune systems can evidently fight it off.

    Tabletop Games 
  • Zigzagged in Bleak World where some of the aliens are horribly damaged by human diseases, but some other Aliens are immune to them completely.
  • Played with in the Classic D&D game's diaboli, a race from an alternate dimension where many aspects of the cosmos are reversed. Not only are the normally-harmless bodily secretions of diaboli deadly poisonous to humans, but human saliva is equally toxic to them.
    • 3rd Edition's disease rules make no distinction based on character species. Unless a race or class is marked as immune to disease, it can contract said illness. Granted, many diseases in the various rulebooks are magical in nature so the normal rules may not apply.
  • The Life-Eater virus in Warhammer 40,000 fluff can scour entire planets clear of life in minutes, no matter what kind of life inhabits said planet. Even Eldar (with quintuple helix DNA) and Tyranids (which may have local DNA salvaged from corpses, but the race as a whole comes from a different galaxy). Some fluff has taken an intelligent turn, and implied that it's a sort of nano weapon.

    Video Games 
  • Averted in FTL: Faster Than Light. One Random Encounter has a plague on a human world. If you have any alien crew members they can help out without fear of contracting it.
  • The Flood from Halo can infest any creature with enough biomass and individual sapience to support the parasite. This specifically excludes Hunters and Drones (being The Worm That Walks and a giant termite, respectively).
  • Discreetly averted as a Genius Bonus in Hatoful Boyfriend. The heroine mentions that just talking to Deadly Doctor Iwamine Shuu can catch you all sorts of nasty diseases; the examples she cites are actual diseases that can affect both birds and humans.
    • Avian influenza, another disease known to make a species jump, is involved in the backstory of birds being sapient, and a fictional virus in the "Bad Boys Love" route specifically has a very different effect on humans than on birds.
  • Played with in Mass Effect:
    • The quarians have impaired immune systems and have to wear suits so they don't get sick. At first appearance, that's this trope, however, Tali explains in the sequel that it's not really an infection: it's an allergic reaction as their body tries to adapt to the foreign substance in their system, the quarians having evolved on a world where all microbial lifeforms were at least partially beneficial and so their immune systems evolved to assimilate the virus, not destroy them like in other species. To use chicken pox as an example, if she were exposed to it, she wouldn't catch chicken pox. She would have an allergic reaction, with similar, flu-like symptoms. They can also take antibiotics and temporary immune boosters to fight infections if their suit gets ruptured (or if they want to take it off to have sex). In addition, quarians have spent the past few hundred years in the completely sterile environments of the Flotilla's ships, and so their immune systems have only continued to grow weaker. In the third game in the best ending of the Rannoch quest, Tali indicates that the geth have started working with the quarians suits to boost their immunity, so soon they'll be able to walk around their home planet without suits.
    • In the first game, the ship's VI makes a point of decontaminating the crew every time they come aboard. This is actually justified, since there are humans at most of the planets that Shepard visits, and there is the possibility (however small) of a cross species disease.
    • Used as a plot point in Mordin's recruitment mission: everyone you speak to in the plague zone knows the disease ravaging the area has to be an intentionally released bioweapon precisely because it's infecting every species except humans (and vorcha, but they're immune to everything).
    • Also used humorously in a throwaway line by Mordin on the Normandy, where he mentions he's trying to figure out how a "Scale Itch" infection got on-board... considering it's an STD carried only by varren.
  • The Zerg Hyperevolutionary Virus from StarCraft is able to infect any alien it comes in contact with. It's also usually paired with a neural parasite. This is Justified by having the virus, as per namesake, evolve rapidly (about a million times more in a week than humans ever have in two million years). And the assumption that everything has DNA to infect. However, it doesn't work on Protoss due to their Psychic Powers supercharging their immune systems.
  • In Sword of the Stars, the disease bio-weapons need to be invented only once and are equally useful against all species. They can be fired in a first-contact situation (before you'd logically be able to dissect a member of said species and find their disease markers) and will not lose any efficiency. The only exception is the Zuul, who are immune to all plague weapons except for the Grey Goo missile no matter what you try.
  • The Turing Test: Apparently, a virus that normally infects an organism found only in Europa is also able to infect organisms from Earth, despite the species selectiveness of real-life virus.
  • In Warcraft III and World of Warcraft, although the Plague of Undeath created by the Lich King only affects humans and not any of the other intelligent species in the game universe, it still has mutagenic effects on plant and animal life. Probably because it's magic and was made to prepare the land for undead invasion. In at least one quest it's explicitly stated to affect some other races, but not fully as intended; one quest involves getting bones from Murlocs that were turned into undead by the plague... but weren't robbed of their free will by it as humans would be.
    • Warcraft also has Half Human Hybrids, despite diseases apparently not translating well among species on the same planet. For example, Garona Halforcen who is half orc and half DRAENEI. Yup, alien parents from different planets. And then she had a son with MEDIVH, who is, biologically, human. So that's 3 species from 3 different planets who are all compatible with one another. Draenei and Orcs in particular are interesting, since their hybrids are clearly still fertile.
    • When the Lich King first came to Northrend, he had difficulty fighting the Nerubians because they couldn't be infected and killed directly by the plague, but they weren't immune to the Scourge's Necromancy, so once some of them got killed by non disease means, they were able to be resurrected as undead slaves. This was later applied to other races as well, which is how you get both the Death Knight class (which can be any playable race except Pandaren) and Dranosh Saurfang.
    • Most humanoid races are affected by the undead plague. Humans, elves, dwarves, gnomes, orcs, and draenei (both from other worlds) can definitely be affected. Humans afflicted with the worgen curse are not affected, however like the Nerubians above, they can be killed by traditional means and then raised via necromancy. The plauge is magical in nature though, so A Wizard Did It.
  • Xenoblade Chronicles X: There is a grand total of one case of disease affecting the humans of NLA on planet Mira, and its cause is quickly discovered and dealt with. There are a couple of other cases though, with one of them being of vital plot importance: the Orphean's "Ovah" is eventually revealed to be a symbiotic virus, and while it's harmless to most species, it does begin getting into some of the native Miran populations, which disturbs the Orpheans greatly; while the plot-important one is the fact that human DNA is extremely toxic to the Ganglion, which as it turns out is the whole reason they wanted to exterminate humanity in the first place.

    Web Comics 
  • Not disease, but medicine - Schlock Mercenary averts this nicely by having characters have med-kits in their tanks specific to their species. These so far have not worked on other species, though there haven't (yet) been any incidences of adverse effects. Medical nanites are more-or-less universal, since they can be remotely programmed or updated with the specific needs of their host body, although a few occasions with extra rare species not in the database require manual configuration by the doctor.

    Western Animation 
  • In Ben 10, each of Ben's aliens manifested different symptoms of his human cold; Heatblast, for example, gets his powers reversed from fire to ice.
  • Invader Zim
    • Somewhat averted when lice broke out and Zim was the only one not infected (Well, there was Miss Bitters, but she ended up getting them at the very end, too.) Turns out there's something in his skin that kills the lice. This is probably the only time in the show where something earthly wasn't harmful to him in some way. It might be possible that Irk once had lice or a similar creature, and their lice killing skin is an adaptation.
    • Also somewhat played with in "Germs," where Zim sees a movie about Earth germs killing alien invaders and becomes insanely mysophobic. The germs never do seem to hurt him, though, implying they probably can't.
  • Justice League
    • One episode had a rogue Amazon trying to wipe out all males on Earth with an engineered gender-specific virus. It even affected Superman and the Martian Manhunter, who aren't human (The latter barely even qualifies as male by human definitions). The worst part is that the "disease" is finally stated to be an engineered allergen, even though allergies don't actually work like that. However, given that part of the creation process involves the use of crushed rubies as a component, most likely the disease is as much magical as it is biological.
    • Played with when Kilowog crash lands on Earth. J'onn is able to treat him to an extent because his own physiology is fairly similar to Kilowog's, but when Flash asks how much he has to guess to fill in the gaps the martian says he doesn't want to answer that question. Still, the drugs he uses all work just fine.
  • In one episode of Star Trek: The Animated Series, the crew visits a planet with sentient plants that were nearly wiped out by a gram-negative bacteria from a human visitor some years ago.
  • Star Wars: The Clone Wars: "Blue Shadow Virus"/"Mystery of a Thousand Moons" have the titular virus, which is highly contagious to all species. This ability is exactly why it's so feared in universe, as not only is no one immune, it's extremely deadly.
  • In Young Justice, M'gann the Martian appears to catch a human flu, prompting Robin to mention The War of the Worlds, as well as mentioning how unlikely that would be. It's ultimately an aversion, since it was actually a power-leaching villain responsible.

    Real Life 
  • Several diseases can do this. The most notorious include rabies, mad cow disease, foot-and-mouth disease, and the infamous avian flu. There's also distinct possibility that virtually all notable human diseases originated from livestock or other animal vectors. Smallpox and anthrax are of bovine origin, influenza of avian and porcine stock, the common cold may be from horses, Ebola is from bats, HIV a variant of SIV from African green monkeys, etc. The only ones that don't show strong relationships with livestock or other animals are STDs, with the exception of HIV. But on the whole, these cross-species diseases are still fairly limited. Rabies, for instance, is stunning in its ability to cross species lines, but is still limited to infecting mammals. It would be unlikely to be found in a reptile, inconceivable in an octopus, and beyond ludicrous in an alien.
    • Mad Cow, more correctly known as Bovine Spongiform Encephalopathy, is a special case as it's not caused by even a rudimentary lifeform such as a virus. BSE is a prion-based disease. Prions are mis-folded proteins that are nonetheless stable enough to interact with a biological system, and several are known to causes diseases. Since proteins are one of the most fundamental building blocks of earth life, it wouldn't be surprising to find prion-based diseases capable of infecting a wide range of earth lifeforms. BSE itself is known to have variants that can infect cows, horses, sheep and humans.
    • Even stranger are Bunyaviruses, Reoviruses and Rhabdoviruses, which can infect both animals and plants.
  • As reasonable as the assumption that Space Germs Are Incompatible With Terrestrial Life Forms may be, it remains a hypothesis until we actually find a Space Germ to use in experimental verification. Since, ideally, one doesn't want to use the entire Terrestrial biosphere as the lab for such an experiment, NASA has a long tradition of quarantine periods for returning astronauts. They also do their best to thoroughly sterilize any outgoing space probes, to avoid contaminating fragile extraterrestrial biospheres. A new host may not have adequate immune defenses against a new infection or infestation, but the parasite/pathogen won't usually be pre-adapted to attack the new host, either. Sometimes the invader won't find anything useful to "eat", or will be defeated by environmental factors such as higher body temperature, but if it survives it may just as easily be able to pig out on undefended tissues - or simply grow in an inconvenient location (e.g. on those nice heart valve flaps...). At this point we still have only Earth organisms to base studies on. Parasitic and bacterial infections are more likely than viral ones, as the former are (in a sense) "eating" parts of the host. Viruses "eat" cells only in a far less literal sense, requiring a certain degree of DNA compatibility to replicate.
    • While bacteria might theoretically be able to infect an alien host, a virus would probably not. A virus needs to recognize a particular DNA sequence to graft itself into the right place on the host's genome, so that it can trick the cell's reproductive machinery into making copies of itself. Even if the alien has DNA — which itself is questionable — there is very little chance that any sequence in its DNA would be of reasonable length to match the pattern that the virus needs, and if the virus was able to adapt it would still need very specific circumstances that are likely unique to Earth.
      • Even if a virus found a DNA-using host cell, and had the right biochemical tricks to enter (viruses normally use some specific proteins on their surface to interact with specific proteins on the host cell in order to enter), and were able to insert their DNA into the host cell's DNA (many viruses don't care where they insert, and have their own support sequences to get themselves copied), it would then almost certainly sit there and do absolutely nothing because the sequences that tell the host cell to make proteins based on the viral genes are extremely unlikely to work on the alien host. Even if they do, the alien host will likely use a completely different coding system for amino acids, and likely some different amino acids as well, making the resulting proteins worthless junk.
    • Going back to the mention of space germs, the notable astronomer Fred Hoyle believed that human noses evolved to point down in order to help keep us from inhaling any microbes that fell from space. He was rightfully laughed at for that hypothesis. Ironically, he may have been right about the "protect from falling germs" idea, just mistaken about where they came from: Earth's atmosphere is saturated with bacteria that rain down on us 24-7, but they're Earth bacteria dispersed by wind.

All Atmospheres Are Equal

  • The planet Namek in Dragon Ball Z has a green sky. That alone should point out the differences in composition with Earth's atmosphere, but the humans that visit this planet, and the Namek natives that visit Earth (and the multitude of other aliens from many different worlds that congregate on either planet) have no problem breathing in it or even fighting at full strength.
    • There's also a scene that lampshades this, where Bulma begins analyzing the atmosphere from inside their ship to see if it's breathable - only to look up and see that Gohan and Krillin are already outside.
  • Brutally averted in Eureka Seven AO when it turns out that the trapar-rich atmosphere is deadly to human-Coralien hybrids as well as non-adapted humans, prompting Renton to send his family to another dimension.

    Comic Books 
  • A Fantastic Four comic 'negative zone' has The Thing and Mr. Fantastic visit an alien space station with an acidic atmosphere. After having his helmet broken it turns out The Thing can breathe the air, it just tastes awful. This is due to his powers however. Another alien has no problem breathing on earth after previously breathing an acidic atmosphere.
  • Inverted in The Scrameustache. Human Aliens wear protective gears on earth because of our pollution. But those who spend too much time on Earth adapt.

    Fan Works 
  • "From Bajor to the Black, Part II" briefly mentions the Bajoran viewpoint character making a side trip to Starfleet Medical for immunotherapy against Earth pollen after arriving at Starfleet Academy.

  • Partly averted in Avatar. Although the atmosphere is primarily oxygen/nitrogen (albeit denser), humans can not breathe it without filters due to the presence of lethal levels of carbon dioxide and hydrogen sulphide.
  • Independence Day provides a logical, lampshade explanation for this entire trope. When asked what they've learned about the aliens' physiology, Area 51 researcher Dr. Okun explains that they're really not all that dissimilar to humans. They breathe oxygen, have comparable tolerances to heat, cold, gravity — which, he notes, is probably what attracted them to our planet in the first place. Ammonia-breathing silicon-based life, who can't digest carbon-based life, would have taken just one look at Earth and moved on.
  • Most of the aliens in the Men in Black films and the cartoon get along fine without special respirators, although there are exceptions: one species risked premature aging in earth's atmosphere, while "Atlantis" (actually a sunken space ship) is a posh resort for (salt)water-breathing aliens. When Agent Jay is surprised at the fish-like aliens, Agent Kay lampshades this with "You think all aliens breathe oxygen?"
  • Averted in Pacific Rim. The aliens that create the Kaiju first attempted to conquer Earth during the time of the dinosaurs, but the atmosphere was too inhospitable for them to move in. Millions of years later humans have polluted the planet to match their standards, allowing them to try a second invasion.
  • As with the planet in Avatar, LV-226 in Prometheus has elevated levels of CO2 supposedly making it dangerous to humans while otherwise having an Earthlike nitrogen/oxygen atmosphere. Oddly enough, unlike Avatar, for some reason they use fully-enclosed helmets instead of just masks with filters. Also unfortunately, they specifically give the CO2 content as the atmosphere as 3%. Humans can easily survive a month or more with no ill effects with 3% CO2, and over a week at 4% after a minor amount of time adapting to it. All those scenes where they're rushing to get into space suits because of an emergency situation that forces them to go outside? Totally unnecessary, as all they'd experience (until they became used to the air) would be potential mild drowsiness and a headache.
    • However, it is not the percentage that makes CO2 toxic but rather the partial pressure. If the atmospheric pressure is greater than that of Earth sea level, an atmosphere that's 3% CO2 could be toxic even if it has tolerable levels of Oxygen.
  • Lampshaded and played hilariously straight in Galaxy Quest, when Tech Sargent Chen opens the door of the ship while it's on an alien planet:
    Guy: What're you doing! We're on an alien planet! Is there AIR? You don't know!
    Chen: (sniffing a few times) Seems okay.
  • Present and subverted (and generally just plain screwed up) in M. Night Shyamalan's Signs. Aliens are seen walking around on Earth apparently sans any kind of protection whatsoever, but then turn out to be fatally allergic to water. (But let's not go into why hydrophobic aliens would decide to invade a planet 75% covered with water, nor how they managed to run through a misty cornfield at night.)
  • Star Wars: Many different species mingle with humans without respiratory problems. For that matter, it seems likely that various human populations would adapt to the particular atmospheric conditions of their homeworld over the millennia and that they therefore could find the conditions on other worlds tolerable but bothersome. There are some exceptions, though, as a few aliens are shown wearing breathing rigs, and the Expanded Universe adds more.
    • It is mentioned that the human Rebels find the Mon Calamari battleships annoyingly warm and humid (Mon Calamari are amphibious and will dry out quickly), but nothing worse than that.
    • Gravity gets a similar minor mention, in that humans who grew up on high-gravity worlds tended to be stocky. Otherwise it really doesn't come up.
    • Star Wars Legends adds more — including at least one which doesn't even technically breathe. It also goes a bit more in depth into this with the Gand, which are technically two species. Group one of the Gand must breathe methane or they will enter a coma state. Group two no longer needs to breathe at all. Then there's the case of the Givin, a race that evolved on a planet with a horrific environment, including massive gravity shifts caused by a destabilized moon. The Givin have an exoskeleton that allows them to survive in vacuum for short periods (their planet would have its atmosphere shredded on a regular basis) and an amazing capacity for mathematics that helped them to predict when these gravity shifts would occur.

  • Averted in The Algebraist by Iain M. Banks, which avoids all of these categories, but especially this one. If you want to survive in someone else's environment (whether their planet or a space station) you better bring a suit. Suits are not always mentioned, because it's so ubiquitous, it would be akin to mentioning that a person is wearing clothes. Alien environment, alien suit. This means alien breeding, cuisine and diseases are right out.
  • Averted in one of the early volumes of Animorphs, without ever leaving Earth. The kids try to use their freshwater trout forms in the ocean, and barely survive long enough to escape their attackers. The next time they plan an ocean mission, they get dolphin forms first.
  • There is a short story by Isaac Asimov where a race of aliens can breathe quite well on Earth... so long as they have a flask of hydrogen cyanide to breathe from every few minutes. Another story has aliens who, when they visit human planets, require filters to absorb carbon dioxide - it is highly toxic for them.
  • Averted in Timothy Zahn's Blackcollar. The hero has an allergic reaction to the atmosphere of one planet, requiring him to swallow medication in regular intervals or suffer an asthma attack. In the same novel the evil aliens have no problem breathing the same atmosphere as humans.
  • Averted in the Corean Chronicles. The native climate of the world was hostile to humans, especially in terms of temperature. Modification of that climate drove the native species to gradual extinction.
  • Averted in Larry Niven's The Draco Tavern. Either specify Tee Tee Hatch Nex Ool (or Tefee Tee Hatch Nex Ool for some lighter gravity) before you take your suit off, or die horribly.
  • Averted in a Nicholas Fisk short story. Human spacemen discovered a cute photogenic alien on a hostile unpleasant planet. They took it home, carefully replicating the environment they found it in. Turns out the sentient alien was an explorer, only able to cope with the hostile environment for a short time. As the alien transformed from cute and photogenic to sick and ugly, the humans lost interest and it was able to escape. Turns out earth rain and atmosphere were perfect conditions for recovering. Plus food for the soul in a friendship with a little kid.
  • Averted in Freehold by Michael Z. Williamson. The Earth-born protagonist spends her first three days on Grainne feeling absolutely miserable from a combination of higher gravity and unfamiliar air contaminants (e.g. pollen from plants that don't exist on Earth). The locals are nice enough to warn her about this ahead of time; they call it something akin to "newcomers' disease".
  • Slightly averted, yet mostly played straight, in Julian May's Galactic Milieu Trilogy/Pliocene Exile saga. The Ship specifically searched for a highly compatible world for the Tanu/Firvulag, only finding one several galaxies over and dying in the process of getting them there. Later, the Milieu is largely composed of mostly biologically compatible species - the Krondaku are uncomfortable on Earth, as it lacks enough oxygen and has twice the gravity of their homeworld (although it supplies some of the galaxy's top-notch booze); the Gi are also a light-grav species (although more socially incompatible); normal enough for the mostly photosynthetic Simbiari (although high concentrations of CO2 are an intoxicant); eminently compatible for the Poltroy, if a little warm and lacking in those so-tasty sulfites; it's a good question if the Lylmik even have a metabolism, being mostly incorporeal, but if they ever did it was pretty wild (the few glimpses of their ecosystem are alien in the extreme, and explicitly stated to be artificially constructed to be at least slightly compatible with all the other races); and the strangest human of the lot, Jack the Bodiless, is perfectly compatible because he requires little more than light and the odd organic molecule, and is otherwise completely unaffected by the environment.
    • Also, a Krondaku love-bath is hallucinogenic to humans, and would serve well as a medium-grade machine oil, being mostly liquid hydrocarbons.
  • Quofum, a mysterious world near the Humanx Commonwealth, has an insanely diverse ecosystem, featuring organisms with radically different biochemistry - carbon-based, silicon-based, sulfate-based, gaseous, etc - living side by side. By rights, most of these lifeforms and/or their waste products really ought to be poisoning one another, and the atmosphere shouldn't even be stable, let alone breathable to humans. Yet neither humans nor thranx have any trouble breathing there, and the only signs of an unusual chemical environment are a pink sky and oceans that are 9% alcohol. Granted, the whole planet is a Xunca experiment, so habitable conditions may be maintained artificially no matter how incompatible its life forms.
  • Subverted in The Martian Chronicles, when the parent Martian at the beginning of the book assures the child that there can be no life on Earth because the planet has too much oxygen in its atmosphere.
  • Averted in the Robotech II: The Sentinels novels. The Garudan's homeworld is oxygen-rich much like that of the Humans and other aliens, but also contains chemicals and microbes that for the other races are the equivalent of breathing LSD with your air.
  • Sector General has oxygen-breathers, water-breathers, chlorine-breathers, methane-breathers, cryonic methane-breathers, oxygen/micro-organism breathers/eaters/drinkers and whatever-the-radivores-breathe-breathers, and the Hudlars (classification FROB) require a different kind of oxygen-atmosphere, having evolved on a high-gravity planet with a very thick, high-pressure oxygen atmosphere (the make-up of which is an occasional minor plot point, albeit purely because Hudlars "eat" by absorbing micro-organisms and nutrients through their skin). However, the extremely tough tegument they are covered in (among other things) means that they can actually survive in a vacuum if need be, provided they get sprayed with nutrients often enough.
  • In the Uplift universe, there are only a few of atmosphere types used by intelligent life: reducing Jupiter-like atmospheres used by hydrogen breathers; nitrogen-rich oxidizing atmospheres used by oxygen-breathers; and rare worlds with fluorine, chlorine, methane, or ammonia-based life. For 2 billion years, the oxygen and hydrogen civilizations have terraformed nearly every potentially-habitable world in the Five Galaxies, making them compatible with each other and seeding them with primitive life-forms. Earth was probably terraformed too, before the Galactics lost track of the planet sometime in the Precambrian. Thus, humans and most oxygen-breathing aliens have little trouble breathing on most oxygen worlds, though there are exceptions.
  • Averted in Lois McMaster Bujold's Vorkosigan Saga, where people only terraform planets with enough oxygen that they can tweak the atmosphere to the Earth norm. On Komarr, the same atmospheric chemicals are present but oxygen levels are much lower, requiring breathing equipment if you go outside. (There are no intelligent aliens; most alien life-forms we meet are similar to insects.)

    Live Action TV 
  • Averted in Babylon 5 in that there are sections of the station sealed off for species that breathe atmospheres other than the oxy-nitrogen standard that seems to be common among the humanoid races. Some of these zones were mild enough that humans could enter them with just respirators, while others (never seen on screen) were apparently nasty enough to require full pressure suits. This difference is mostly informal, since except for the encounter suit-wearing Gaim and Vorlons (the latter don't actually need them) and whatever Na'grath is supposed to be, any alien we see on Babylon 5 is effortlessly capable of surviving in earth-like atmospheric conditions. And a simple set of gill implants seems to enable oxygen-breathing species (or at least humans and Narn) to survive in even the Vorlons' CO 2/sulfur/methane atmosphere without any external equipment.
  • Largely averted in Defiance - aliens from different planets in dying star system left in an exodus fleet for Earth, spending hundreds of years in suspended animation during the voyage. They did spend many years picking a target world, and even current human technology can perform some basic gas spectrometry on distant stars, so they apparently picked a target solar system where they thought there was a planet with an atmosphere they can breathe. There are five major alien races (plus two minor ones: one is entirely energy-based, the other are cybernetic warriors). All five seem to be able to breathe Earth's atmosphere without assistance. One point brought up is that the dwarf-like Liberata actually breathe nitrogen, not oxygen - but Earth's atmosphere is an oxygen-nitrogen mix, so they can still breathe the air just fine.
  • Pick any story of Doctor Who out of the TV series, novels and comics. There's a good chance this is happening.
    • Which is actually justified, as the Doctor doesn't want to go to any planet where the atmosphere can kill them. It's likely the Doctor goes to planets that are habitable to both Time Lord (and humans).
    • The TARDIS has a protective field maintaining an atmosphere around it (several episodes show them sitting in the doorway in open space) and it has a lot of sensors making sure the place is habitable before anyone steps out. Particularly during the First Doctor's time, he would pointedly make sure the place was safe before stepping out. (The first time they visit Skaro, it is a plot point that the radiation scanner malfunctions and fails to alert them to the high radiation.)
    • "The Web Planet" takes place in another galaxy, and the main characters are occasionally mildly affected by the different atmosphere.
    • In "The Waters of Mars", the Doctor goes to Mars and is wearing a space suit.
  • Farscape usually played this trope straight in all its incarnations but the atmosphere issue is subverted in one episode. In "Relativity" the alien mercenaries employed by Xhalax are used to much less air pressure so they have difficulty keeping up with her.
  • Power Rangers as a whole. Not sure whether the ranger's armor acts as a protective gear (surely it does in Power Rangers in Space). But anyway, humans, Human Alien good guys and Dark Specter's forces can breathe on each other's planets. Oh, and apparently you can breathe on Moon, and it has the same gravity as Earth.
  • Justified in Stargate SG-1. As Carter points out, you don't make easy travel to planets that are going to kill you if you go there. Also subverted several times when they do run across lethal atmospheres, usually caused by some kind of disaster like a volcano. In one case it was a radically different form of life terraforming the planet. They always send through a robot probe before going to an unknown planet.
    • Also justified because the Ancients had the same or very similar chemical composition as modern humans, and deliberately built their Stargates on planets they could inhabit in the Milky Way, or terraformed the planets prior to placing stargates. On uninhabitable planets with Stargates, it's often commented that "this planet was probably just like Earth millions of years ago".
    • Averted in "Scorched Earth", where an alien terraforming vessel is replacing the ecology of an Earth-like planet with a sulphur-based ecology where the air needs to be mostly hydrogen sulphide. Meanwhile, the conflict of the episode derives from the fact that the colony of Human Aliens SG-1 relocated there needs a much thicker ozone layer than usual or they go blind.
  • Star Trek is a frequent offender here. Given that the majority of the crews found aboard the ships the various series center around are human, it is reasonable to assume that the air they breathe is adapted to human physiology. Other oxygen-breathing species are almost never shown to find the pressure, temperature or the (presumable) presence of nitrogen and water vapour bothersome. The Benzites are the only race that's been described as needing something other than oxygen/nitrogen. It's possible the Breen count too, since those refrigeration suits aren't needed, as well as the Tholians, who naturally live in temperatures of at least 450 Kelvin (177 Celsius). This is given a Hand Wave by an episode of Star Trek: The Next Generation, which explains that most of the species in the Alpha Quadrant did in fact descend from the Precursors, who scattered their genetic code across thousands of worlds, apparently Genre Savvy enough to know that their own society would inevitably grow proud. This goes some way to explaining why Rubber-Forehead Aliens tolerate nitrogen/oxygen atmospheres, as well as other forms of alien/human... interaction.
    • There was a nice moment in a Deep Space 9 episode that seemed to acknowledge this, where Garak, a Cardassian, comments that the environmental settings on the eponymous station, adapted to Bajoran/human norms from their Cardassian originals, are uncomfortable to him - "the temperature is always too cold, the lights are always too bright". So even amongst Star Trek's rubber forehead brigade there are still variations in environmental tolerance. It's regularly pointed out that Cardassians tolerate temperatures too hot for many others, and scenes that take place in Cardassian settings are usually filled with muted colours and lower lighting levels with non-Cardassians require cooling units to survive with their insanity in check.
    • There's another mild aversion in Deep Space 9 when Kira and Bashir are discussing the atmospheric requirements for a visiting ambassador.
      Bashir: Sixty percent nitrogen, ten percent benzene, and the rest hydrogen fluoride, as I recall
      Kira: Well we ran a test in one of the guest quarters. The mixture is so corrosive it dissolved the carpet.
      Bashir: Don't look at me. It's what they breathe.
    • Another DS9 episode dealt with a woman who came from a planet of much lower gravity.
    • A plot point of the TOS episode Amok Time is that Vulcan's atmosphere contains less oxygen than humans are used to. Also, when afflicted with rapid aging in "The Deadly Years", Spock found it more difficult to tolerate the (for Vulcans) cold temperature of the ship environment. Presumably, he normally just puts up with the discomfort.
    • Although fine in Earthlike temperature ranges, Klingons have more difficulty dealing with colder temperatures than many species.
  • In UFO the aliens have the technology to adapt human organs to replace their own, yet wear spacesuits as exposure to the Earth's atmosphere will kill them.

    Tabletop Games 
  • Averted in GURPS: Space most of the possible atmospheres are both suffocating and toxic.
  • Averted in Dungeons & Dragons when traveling the planes. Depending on the plane you go to, problems may include but are not limited to: having the life sucked out of you, too much life being crammed into you, obscenely high temperatures, obscenely low temperatures, lack of atmosphere, poisonous atmosphere, or in some extreme cases whatever the DM feels like screwing the players over with. The only not immediately disastrous plane would be Elemental Plane of Air - it's perfectly breathable, and while endless freefall is annoying there is no ground to actually kill you with the landing.

    Video Games 
  • When the protagonists land on an alien planet in The Dig, their spacesuits automatically test the composition of the air, which is declared "at least as breathable as L.A." One character brings up the possibility of alien pathogens, but another replies that such organisms would be unable to make use of their cellular structures. Still later, they encounter a form of alien medicine that does work on humans.
  • In Final Fantasy IV, the party goes from the surface of the planet to the deep underground—with oceans of lava bright enough to provide ambient light. Then they visit the surface of the Moon, a barren wasteland populated by human-sized versions of (single-cell) eukaryotes and prokaryotes. A case could be made for the latter, but the former should have a noxious atmosphere and should make it impossible for humans to survive in it (to say nothing of the heat and pressure...)
  • Averted in Galactic Civilizations. Among the colonizable planets are worlds with toxic atmospheres. To colonize them, you have to research atmosphere purifying technology first. Several species (like the Korath) have a natural tolerance to the toxins and can colonize such worlds from the start. Its is, however, played straight when conquering another planet, as the new inhabitants don't to have any problem adapting.
  • Averted with the Grunts of Halo. The massive suits and rebreathers they wear provide them with the methane atmosphere they require. All the other known species (including humans) seem to be adapted to the same atmospheric conditions, which might be because the evolution of most sentient life in the Milky Way was at least partly guided by the Precursors. It's also implied in supplemental material that Grunts may have evolved to breathe methane after they wrecked the atmosphere of their planet with over-industrialization.
  • Mass Effect deserves a third mention:
    • Apparently, the volus homeworld is a high-pressure cocktail of ammonia and other caustic gasses; all the volus we see in-game wear high-pressure suits, and it's implied that, without them, their skin would split open from their bodies' internal pressure. Ew.
    • There's also a planet you can go to on one of the side missions that is very close to being Earthlike. It even actually has more oxygen than Earth...which is part of the problem as the thunderstorms on the planet are magnified to horrifying intensities. This, plus toxic pollen rampant in the atmosphere, makes it thoroughly unsuitable for human life.
    • In the first game, a good percentage of the planets you land on are hazardous. The hazard can be due to extreme temperatures, extreme pressure, or atmospheric composition that's toxic to your team.
    • Mass Effect 2 has this happen to the quarians within their own fleet, again due to their weak immune systems. The codex entry on the Migrant Fleet mentions that if a quarian visits a different ship in the flotilla (one reason for this is dating), they spend at least a couple of days feeling miserable as their bodies acclimate to the slightly different atmosphere and contaminants on the other ship.
    • Mass Effect 3 makes mention of the fact that rachni typically live only on planets that are exceedingly hazardous to most other forms of life, and finding them on a planet with an atmosphere comfortable for humans and krogan is rather unusual.
  • Averted in the Metroid series: after the Chozo took the infant Samus Aran under their care, they subjected her to a carefully designed series of transgenic modifications with Chozo DNA, so she could merely survive in the unbelievably hostile atmosphere, and pressure, of Zebes. Even then, many parts of Zebes, to say nothing of other planets, are impassable to her without the Power Suit's environmental protections.
    • Possibly played straight in Metroid Prime 3: Corruption, as the Federation Troopers also consistently wear powered armor everywhere Samus goes (so their armor presumably provides similar environmental protection and breathable air), but Admiral Dane never wears as much as a facemask—not even on the Pirate Homeworld, which has acidic rain that can destroy the Power Suit in seconds.
  • Averted in the Myst Verse, in which one of the major guilds of the D'ni civilization had the responsibility of checking newly-written Ages to determine if they were safe. The first explorers to link to an undocumented or rediscovered Age would do so in protective armor with its own air supply.
  • Averted in Pikmin. It's stated several times that the atmosphere of the planet Olimar gets stranded on contains a large amount of oxygen, which is highly toxic to his species. This is also why he has to repair his ship in thirty days, as this is how long he has before his suit's life support runs out.
    • In the third game of the series, you don't play as Olimar but as an exploration team from a neighbouring planet (Koppai) to Olimar's (Hocotate). It's stated that there is oxygen in Koppai's atmosphere, but in much lesser concentrations than on the Pikmin's world (dubbed PNF-404). As such, the Koppaites don't wish to risk removing their spacesuits to see if they can breathe the same air as the Pikmin. It's also suggested by one of the Koppaites that the reason that there are so many comparatively large creatures on PNF-404 is, in part, a result of the amount of oxygen in the air.
  • Averted in the Sid Meierís Alpha Centauri: Alien Crossfire expansion pack - Progenitor and human biological needs are so different that they cannot coexist in colonies together. In game terms, what this means is that when a human faction captures a Progenitor colony (or vice versa), the colony is depopulated to 1 population, and a number of colony pods (based on the population of the colony) are generated, representing the displaced population. Also there in the manual for the game: the atmosphere of Planet is also nitrogen/oxygen, but the proportion of nitrogen is 90% instead of 78%, and the atmosphere overall is thicker so that while the partial pressure of oxygen is within acceptable limits, the amount of nitrogen you'd have to breathe in would give you nitrogen narcosis. Settlers are mentioned wearing special masks at minimum, and your soldiers are depicted wearing what appear to be pressure helmets, although otherwise clothing is fairly "normal" (since other than being a bit off for breathing, Planet's atmosphere does the job just fine). The tie-in novels mentioned that it was possible to go without a mask for short periods of time, so Deirdre made quite an impact on another faction by emerging from her vehicle, unmasked and smiling.
    • Same in the Spiritual Successor, Civilization: Beyond Earth: all humans need spacesuits or equivalent protection in the open atmosphere, and some regions harbor pockets of corrosive "miasma" that is harmful even in protective gear.
  • The Zerg in StarCraft, they are created to thrive in any atmosphere, and even in the vacuum of space. StarCraft II plays this straight during the invasion of Char. Despite the fact that the entire world is a giant volcanic hotspot, the surface consists of compacted ash and solidified lava, and open pits of lava are the equivalent of oceans... humans can still walk around with open helmets. And the rain is apparently perfectly neutral water rather than the expected acid rain. The Zerg might have modified the atmosphere more to their liking, but considering they can do fine in a vacuum and evolved on an even worse world, that seems doubtful. Amusingly, General Warfield had specifically stated earlier that the atmosphere could "burn a man alive". Despite the hellish conditions Char was actually a major colony in the Confederacy due to its large supplies of minerals. The Terrans eventually fought a nuclear war over said minerals, waking several previously dormant volcanoes and producing radiation so dangerous in some areas even fully armored Marines can't survive exposure.
  • Stellaris has "toxic" worlds but they're simply unihabitable and all sapient species seem to come from planets with Earth-like atmospheres, with the biome being the main criteria for determining whether a species can colonize.
  • Sword of the Stars at least averts this one, as all races have their own preferences for atmosphere, gravity, humidity and temperature that makes it difficult for two or more species to share a planet without high-level environmental engineering tech. The preferences are randomized each game, which can have interesting results.
  • One log in System Shock 2 had a tech complaining that people were so eager to get credit as the first person to set foot on an extra-solar world that they didn't wait for him to finish checking to see if the air was breathable. It was, but given what they found on the planet, they might have been better off if it hadn't been.
  • X-COM: UFO Defense (UFO: Enemy Unknown for you Brits) both averted and played this straight. The eponymous aliens comprised many races - some were surgically altered to deal with the atmosphere, others were genetically engineered badasses, some used their Psionic powers to support their atrophied body mass... and some just seem to do fine without any help. Including, apparently, humans on Mars without full environmental armor. Possibly an oversight, since by that point in the game, you should probably have all of your troops outfitted with Powered Armor and plasma weapons.
  • Xenoblade Chronicles X: Averted with the Zaruboggan, who have to wear sealed environment suits at all times and consume radiation and toxic waste as food. They don't like the verdant planet of Mira very much: all the pure water and clean air is deathly toxic to them. Their biology does make them very popular with the humans' waste disposal personnel, though, and the Zaruboggan are in turn only too happy to be provided with plenty of "voltant" to consume.
  • Averted in the X-Universe series. The Boron evolved on a world with an ammonia atmosphere.

    Web Original 
  • While Heaven and Hell in The Salvation War have a breathable mix of oxygen and nitrogen, and Heaven's air actually is described as being so fresh it almost tastes like wine, Hell's atmosphere is filled with large amounts of volcanic ash. Not only did it cause all kind of problems for any kind of intake engine used in Hell, humans found out the hard way that long term exposure without the proper breathing equipment leaves fatal amounts of dust clumped up in the lungs.

    Western Animation 
  • Very few of the aliens in the Ben 10 franchise seem to have problem breathing Earth's atmosphere, including those the titular character transforms into. Water-breathing aliens seem to be the only exception (and any kind of water seems to be ok). As of Ben 10: Omniverse it seems most aliens the titular character transforms into have no trouble surviving in space, so Earth isn't much of a stretch.
  • The Fairly OddParents!.
    • Cosmo doesn't quite understand what's wrong with visiting 'The Planet Of Not Enough Atmosphere'.
    • Norm wanted to abuse this, trying to convince Crocker to just wish Timmy to Mars (which is almost nothing but carbon dioxide, and no human would survive on it for long), but Crocker has other plans.
  • Invader Zim again. Irk, Foodcourtia, Earth, and Conventia don't all need to have the same pressure and those there need not all breathe oxygen as, at least in the case of the Irkens, they have atmospheric processing units (in the PAK). No matter what planets the Irken Invaders go to, they can always handle the atmospheric pressure. It may be possible that many of them are wearing their invisible space helmets, but that's kind of unlikely. Until it rains.
  • Averted in Teenage Mutant Ninja Turtles (2003), when the turtles end up in the Triceraton world, they can't breathe well because their atmosphere has extra sulfur in it. They are given special breathing gear to survive long enough to be prisoners.
  • Lampshaded for comedic effect in Toy Story. Woody opens Buzz Lightyear's helmet accidentally, and Buzz starts choking, expecting something deadly. He suddenly realizes...
    The air isn't toxic...? How DARE you open a space ranger's helmet on an uncharted planet! My eyeballs could have been SUCKED from their sockets!
    • Even funnier when one considers that he doesn't even have lungs, being a molded hunk of plastic. Of course, he doesn't know that...
  • Cybertron in Transformers is shown to be equally hospitable to humans, various aliens, and robots with no need to breathe. This is despite there being no visible atmosphere in most of its depictions.
    • It is also the altmode of the Physical God who created the Transformers, and who seems to encourage them cooperating with other species, especially humans. Retroactive Fridge Brilliance perhaps?
    • One of the very first things we see on the planet, in the pilot, is a huge fire. Later episodes revealed that under the surface, there is organic earth to be found, and if we go all the way trough Beast Machines, it is out-right stated that plant life did indeed live on the planet. The lack of visible atmosphere in the artwork seems to be the biggest problem, as everything else suggests there is one.
    • Averted in Transformers Prime where the environment on Cybertron is deadly to humans: the human characters have to either wear space suits or be in some kind of enclosed container. The Decepticons force the Autobots to surrender during a battle by threatening to open the containers they have the three kids in.

    Real Life 
  • Fish, squid, etc. can extract oxygen from water just fine, while humans and any other animal with lungs can't and will drown. On the flipside, dry/collapsed gills cannot function. And they dry very fast. There are species of fish that can survive prolonged exposure to air, and just a slight chemical difference in the water can kill an organism with gills. And never transplant a saltwater fish to a freshwater, or vice versa. Unless it's a salmon, and they can't move directly from salt water to fresh water or vice versa; they need time in an area that is a mix of the two. Ditto for eels.
  • Humans can tolerate all kinds of pressure and gas differences, as long as whatever we're breathing contains an approximate partial pressure of 3.0 psi oxygen. Heliox (helium-oxygen mix, containing no nitrogen at all) has long been popular with technical divers at extreme depths, as the lack of nitrogen removes one possible avenue for pressure toxicities. On the other hand, oxygen toxicity becomes a real problem at those kinds of depths, so you have to carry multiple mixes, in separate bottles with separate breathing rigs. And God Himself can't save you if you breathe from the green bottle (100% oxygen) at deeper than about 20 feet of salt water.
    • Even breathing from liquids isn't impossible if they contain sufficient amounts of oxygen (ala The Abyss), although usually only with mechanical assistance as human lungs don't have the power to move the necessary amount of liquid substance to get enough CO2 out and enough oxygen in, and if you spend too long in the oxygenated fluid your diaphragm will eventually tear from the strain of having to move the much denser (compared to air) liquid in and out of your lungs.
    • For an air pressure example, humans have climbed Mount Everest without oxygen tanks. It is not for everyone and you can get away with being there briefly, but you won't survive if you stay.
  • Approximately 2.6 billion years ago, the oxygen molecule was poisonous to all life on Earth, save a few microorganisms that invented aerobic respiration to use the tiny amounts generated by UV diffraction at the ocean's surface. Then a new way to extract energy from the environment appeared which we now call "photosynthesis" which transforms carbon dioxide and water into sugar and oxygen. Over a period of roughly 200 million years, the cyanobacteria that produced oxygen became more successful, killing off almost everything that could not adapt to its effects. Rightfully so, scientists called this event the Oxygen Catastrophe. Nowadays, lots of Earth life depends on oxygen to survive, but anaerobic microbes are still kicking around in sheltered micro-biomes - such as your gut. There are also some microbes that cannot do anything useful with oxygen but don't get killed by it.