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Anime & Manga
- Dragon Ball Z has Goku face a giant snake called Princess Snake. He defeats the snake by flying around it until it ties itself into a knot trying to eat him.
- Incredible Hulk
- Hulk has at least once defeated Mr. Fantastic of The Fantastic Four by tying him in knots.
- He also tied Doc Ock's arms into knots in retaliation for the beating he received in a Sinister Six storyline.
- In the X-Wing Series, a teenaged Wedge Antilles was restrained by Booster's tentacled copilot while going berserk as his parents were dying. Somehow, off panel Wedge slipped out and got to a window, and the copilot was seen looking startled with its tentacles knotted.
Films — Animation
- In The Jungle Book, Mowgli pushes Kaa's coils off a tree and he collapses on the ground in a tangled heap. As he crawls away, his tail ends up tied in a knot, which gets snagged and trips him up.
- In Robin Hood, Prince John punishes Sir Hiss by tying a knot on his throat, then later by tying him around a pole.
- The animated film The Secret of Kells has the boy protagonist face off against a tentacle monster to retrieve another magnifying crystal to replace the one his mentor lost years ago. Part of his tactics for defeating the thing invokes the trope as he evades the tentacles.
Films — Live-Action
- In Night at the Museum: Secret of the Tomb, Larry escapes from one of the Xiangliu's heads this way.
Myths & Religion
- When attacked by two snakes, the baby Hercules defeated them by tying them together.
- In the video game adaptation of Hook, the instruction manual says that the reason the snake enemies are attacking you is because you used to tie them into knots when you were a kid.
- The Adventures of The League of S.T.E.A.M.: In "Tall Tails", three men boast of their encounters with a kraken, including one man who claims he defeated it by tying its tentacles in a nice square knot. While he's talking, a kraken attacks, but as the man only has one arm now, he's got a good excuse not to volunteer to fight it off. "I need two arms for that!"
- Looney Tunes short "The Great Piggy Bank Robbery". Duck Twacy (Daffy Duck) hunts down the gangsters (all inspired by Dick Tracy villains) who stole the piggy banks. One of them is Neon Noodle, a Frankenstein's Monster lookalike made of neon tubing. Twacy wrestles him and turns him into an "Eat at Joe's" sign.
- In the Silly Symphony short "Birds in the Spring", a bird escapes a snake by flying through a hollow log and letting the snake tie itself up on the knotholes.
- Static Shock: One of the openings has Static using complex maneuvers against Rubberband Man to make him tie himself up.
- The Simpsons: In a Treehouse of Horror epsiode, Bart becomes a Rubber Man calling himself "Stretch Dude." At one point the Big Bad has SD and Clobber Girl (Lisa) suspended over a vat of boiling lucite, tied there with Stretch Dude's own arms.
- While the tentacle monster in Futurama's "Beast with a Billion Backs" is not defeated this way, this method or a similar one is used to delay Leela's capture to it.
- As in the mythology example, this happens to Pain and Panic when they try to kill baby Hercules in Disney's Hercules.
- Ben 10: Omniverse: Princess Looma manages to do this to Ester when they fought.
- In one episode of Superman: The Animated Series, Superman uses this tactic to defeat an alien monster with multiple tongues.
- In the 1980s The Chipmunk Adventure movie, the Chipettes escape from a room full of snakes by tying two of them together and using them as a rope to get out of a window.
- In the opening to his cartoon, Touché Turtle does this to a land-walking octopus.
- In an old Felix the Cat cartoon, Felix travels underwater in search of a pirate's treasure and is forced to fight a boxing octopus for it. To win, Felix grabs each of the octopus's tentacles when it tries to punch him and ties them together.
- Star vs. the Forces of Evil: Star and Marco defeat a Hydra with quick maneuvers to tie its necks up into a knot.