Is it just me, or does it seem like after Filburt and Dr. Hutchinson got married, there seemed to be little subtle hints that she was cheating on him? Perhaps one of their kids looking exactly like Heffer isn't quite so subtle (though they never explicitily suggested that she and Heffer had any kind of encounters), but there did seem to be other hints, such as this:
Hutchinson: I keep a baboon's heart under my pillow.
Filburt: What's that?
Hutchinson: Uh, nothing dear. *Chuckle*
Why exactly is Dr. Hutchison's mother named "Widow Hutchison" when her husband is alive the whole time? And he's a turtle!
It's likely he left her ("Frank! You've come back! Wait, I still love you!") Hutch also mentions an falling out as well, I think, and it turned her in the usual bitter, spinster type since she thinks of him as "dead", almost like Mr. Bighead's I Have No Son thing with Ralph. The turtle thing could be Irony considering Hutch's mom seems an little more than eager for her and Filbert to split up along the lines of "don't follow in my footsteps because I fell in love with an turtle and look what happened to me." Hutch's dad even lampshades the mourning thing.
Frank: Still in mourning, I see?
Widow Hutchison: Shut Up.
Why does Ed Bighead's position in Conglom-O change in different episodes, one episode had him as a CEO but then it got changed to Mr. Dupete as the CEO despite being a boss at a comic store, how does that work?
Maybe Conglom-O owns the comic store and he works there some days to make sure things are going smoothly. He could be an Undercover Boss.
Considering the episode where Ed was the CEO, while Mr. Dupette ran a comic book store was one of the first, it's possible that it was all a Retcon since earlier episodes of almost every show tend to have different continuity than the rest of the series.