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- Angel Catbird: The orphan cat-boy the group finds on the way to Castle Catula is adopted by the Russian cat-lady.
- A strip on the back page of a The Dandy comic featured an elephant sitting on a tree branch eating a banana next to two monkeys. One of the monkeys says to the other "I think the time has come to tell Junior he was adopted".
- Disney Ducks Comic Universe: Huey, Dewey, and Louie seem rather content to live with their maternal uncle instead of their parents... despite the fact that he is very much a jerkass with a horrible temper who cannot hold down a job. They also seem to develop into far more functional citizens than him, so it seems to work. Writers who care tend to emphasize that Donald Duck is a Jerk with a Heart of Gold, though one Darker and Edgier interpretation is that their mother and father actually are that much worse than Donald — which actually is Truth in Television for some real adoptees.
- Lampshaded in several comic stories, where Huey, Dewey, and Louie lament their uncle's many shortcomings, only to realize that when it comes down to it, he actually is a pretty good legal guardian.
- Donald himself is shown in many comic stories about his childhood being raised by Grandma Duck.
- Gold Digger: Brittany Diggers is an orphaned were-cheetah, taken in as an infant by Theodore and Julia Diggers, and raised as a sister to their own daughter Gina. They see her as nothing less than family, and the feeling is mutual. Eventually the comic makes "family isn't just blood" go up to eleven when a sorceress tries to kill Brit, Stryyp and their daughter Tiffany, and even if the spell explicitly says that only people from the same bloodline are effected by it, the whole Diggers family ends up in it and pull a Big Damn Heroes moment.
- Hellboy knows perfectly well that he was adopted (being a huge red demon with a Right Hand of Doom is kind of a giveaway), but he has a genuinely loving relationship with his father, Professor Bruttenholm.
- As in the cartoons, all of Jem and the Holograms (IDW) members are sisters. Aja and Shana aren't adopted, they were foster children, but are still explicitly refer to as Jerrica's and Kimber's sisters. Compared to the cartoon everyone generally acts much more familial and affectionate.
- Alex and Freddy of Mega Robo Bros are robots who were adopted by a human couple when their creator disappeared. They couldn't be happier.
- In Ninja High School, Anna Feeple (previously Anna Ichinohei), Jeremy's mother, was brought into the Ichinohei clan after her mother was killed while helping Kudasai during the second World War.
- Paperinik New Adventures: After crashing on Earth, Everett Ducklair lost his memory and, due to being Older Than He Looks, was adopted by a couple of very loving humans. Unfortunately, discovering his true past created a strain on their relationship.
- Tintin: Towards the end of Tintin: The Blue Lotus, Chang Chong-chen is adopted by Wang Chen-Yee. He's overjoyed to learn that he's going to have a family.
- W.I.T.C.H. has quite a few examples. In chronological order of the trope becoming evident, they are:
- Elyon, Queen of Meridian, was raised by Miriadel and Alborn shortly after her birth, but didn't know she was adopted until they explained this much later. In the end, she accepts them as her actual parents. And given that their natural appearance is disconcerting makes Elyon's acceptance that much more heartwarming.
- Irma's biological mother is nowhere to be seen, but her relationship with her father's second wife Anna is so good, and their resemblance so uncanny, that it's actually a shock to the reader when, during a fight, Irma throws in her face she's her stepmother.
- The New Power story arc reveals, to her and the reader, that Taranee Cook was adopted, with her birth parents having put her up for adoption when their house was struck by a meteor and burned down and they couldn't care for her anymore. After a brief moment of rage, Taranee decided that her adopted parents were her real parents and burned down the contact information for her biological parents her stepmother had kept just in case.
- Late in the series, Will: her mother Susan divorced her father for very good reasons and remarries with Dean Collins during the series, and some time after the New Power arc Will starts to see Dean as her actual father, even calling him "dad". The fact that, by that time, Susan had given birth to Dean's son may have helped.
