Killian says that taking down Gizmo in Junktown should be pretty funny, just to watch the Fat Bastard try to run away. Sure enough, Gizmo remains planted at his desk.
On another note; if you didn't get rid of Gizmo in Junktown, the ending might actually make you belly-laugh. "He profits the most, and continues to increase the size of his casino, and the scope of his power, until he chokes to death while eating some iguana-on-a-stick."
Upon meeting the Brotherhood of Steel for the first time at the Lost Hills.
Darrel: The Brotherhood is a collective of men and women who have dedicated their lives to the preservation of technology. Vault Dweller: I've heard that you people sacrifice puppies.
When you visit the Cathedral, an incredibly dark and creepy church, you're either infiltrating a crazy cult or trying to defeat the Master. This is why hitting on Laura feels a bit out of place.
Laura: Hello, my brother/sister. May I be of service this glorious day? Vault Dweller: What kind of "services" do you offer? Laura: (Angry Face)
Lieutenant: Morpheus. It's quite amusing. He think he's more than a pawn the Master chose to lead the Children of the Cathedral nonsense. Oh well, he too will be dipped in the virus and he'll probably die a horrible death. I hope.
Before entering Mariposa, you could use the radio you looted from one of the mutants to convince them to leave their posts, no matter how bad your lies are.
Vault Dweller: They don't suspect a thing.
If your character is a female and you ask Tandi out after saving her from the Khans, she'll stutter and say she's into guys and quickly says she has work to do.
If you try to talk to the Crimson Caravan in the Hub with low intelligence, they'll tell you that they don't hire drug addicts. You can choose to end the conversation with "I'm no drug add....I mean...Arg!"
At Necropolis, having low intelligence actually allows you to easily talk your way past Harry the supermutant. Well, "talk" is being generous. The exchange consists of both saying things like "What?" "Huh?" at each other a few times, and then the dialogue just ends without anyone turning hostile.
Gizmo: Get your butt in here and sit down. We got some business to discuss. Vault Dweller: Blehh. Gizmo:Get outta here, ya' idiot!
In the first half of the game, the Pip-Boy will have a helpful Post-It reminder stuck to it that says "Things to do!" before mentioning you have to find the water chip in X day. Just the fact that the existential threat to your Vault is written down on the same kind of paper where one would write "go get milk from the grocery store" is pure Black Comedy.
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