The song "Absolutely (Story of a Girl)" is referenced several times in the movie (once by Alpha Waymond explaining the risk Jobu Tupaki poses to the entire multiverse, and several more times as alternate versions of the song performed by Nine Days themselves — a country ballad in the Return Home universe, a version about Raccacoonie in that universe). The opening line of the song is, "This is the story of a girl who cried a river and drowned the whole world." This describes Jobu perfectly.
In the universe where Evelyn is a martial arts movie star and Waymond is a rich CEO, they never got married and had a daughter. Both are also Lonely at the Top, wildly successful but emotionally unfulfilled. They have no joy in their lives. Ironically, this particular universe is where Jobu can't exert her influence since she doesn't exist there. Thus, Evelyn is safe there when she lands to this universe. Furthermore, this is also where she gains the skills (from her action star counterpart) and most especially the mindset (by talking to CEO Waymond) needed to thwart Jobu's threat once and for all.
Likewise in the Alphaverse, while Joy exists in that universe, she is simply known and called as Jobu Tupaki by others, including her own father and grandfather, symbolizing how the constant verse jumping crushed her happiness and become the nihilistic and suicidal woman she is throughout her appearance.
Jobu Tupaki wearing an outfit based on Black Lady makes sense, as the two characters are quite similar. After exposure to dark forces (the Bagel/Wiseman), a young girl (Joy/Chibi-Usa) is brainwashed into thinking she’s alone in the universe, does a Face–Heel Turn with plenty of Kick the Dog, gets a villainous outfit change, and wants vengeance on her parents: a powerful “useless” mother (Evelyn/Usagi) and a loving, kind, protective father (Waymond/Mamoru). She is more vindictive towards her mother than her father. Chibi-Usa travels through time to find Usagi (albeit to save her mom), and Jobu hunts Evelyn down through universes.
The "hot-dog fingers" universe being the one where Evelyn and Deirdre are lovers makes some sense. Typing must be much harder in this universe, so maybe the IRS doesn't even exist or is much looser. Deirdre has a different job and can be less antagonistic with Evelyn.
The hot dog fingers universe may seem ridiculous at first, but one can see it as a way for Evelyn to confront her own homophobia regarding her daughter having a girlfriend. Not only does she find herself in a gay relationship in this universe and is initially rather uncomfortable with it (especially since her partner happens to be Deirdre, the IRS agent who's been giving her so much grief over her taxes in her own universe), but she's also rather disgusted by this universe's bizarre courtship rituals (the weird dancing, the "romantic" act of putting your hot dog fingers in each other's mouths, people secreting ketchup and mustard from their mouths). The hot dog fingers universe allows Evelyn to become friendlier with Deidre in her own universe, and it likely also helps her understand and accept Joy's sexuality.
Organizing a New Year's party at the laundromat probably counts as a legitimate marketing expense, and could in theory justify purchasing a karaoke machine.
Jobu Tubaki's outfit symbolism:
Despite the gaudiness of Jobu Tubaki's outfits, all of them have some form of eye makeup that resemble tears. Her motives are unknown to all and her presence is confusing, but deep down she is simply suicidal and depressed.
All of Jobu's outfits are brightly colored and vibrant, except for the one she wears when she and Main Evelyn appear before the Everything Bagel. Perhaps its a reflection of Evelyn's feelings towards Joy compared to Joy's feelings towards herself: Evelyn sees her as bright and full of life, while Joy sees herself as empty and devoid of purpose or meaning.
Alternatively, Jobu's outfits also represent the generational gap between Joy and her mother and allow us to see her as Evelyn does: after all, how many kids have parents who criticize their outfits for being strange and (what they see as) innapropriate?
The Alphaverse sees Jobu Tubaki as an agent of pure chaos motivated by nothing, even though they have the context for why she acts the way she does (Considering her Evelyn was abusive, it doesn't take rocket science to understand her connection to other Evelyns). They misunderstand Jobu in the same way that Main Evelyn misunderstands Joy, who she thinks is acting contrarian for unknown but seemingly arbitrary reasons, despite the reasons being right in front of her (Evelyn being generally emotionally unsupportive and not super open to her daughter being gay). The Alphaverse fails to understand Jobu despite creating her, and die as a result. Evelyn and Joy eventually reconcile and the universe is saved.
The name "Jobu Tupaki" is intended to be completely meaningless, as a reflection of the character's nihilism. Thing is, given the Chinese background of the main characters (including Jobu/Joy herself), this is impossible. Unlike English letters, which are nothing more than building blocks for words by themselves, every character of the Chinese language is a word in itself and has its own built-in meaning. The closest one can get to a meaningless word in the Chinese language is Word Salad (characters arranged in a fashion that does not construct a logically valid phrase), which "Jobu Tupaki" does admittedly fit.
If the ending of the film takes place in the Return Home Verse, that means that Protagonist Verse versions of Evelyn, Waymond, Joy, Gong Gong, Deirdre and everyone else who was there at the IRS building who got taken over are all screwed. If not for the excessive amount of the fighting and damage done, the fact that at least one person was murdered in the IRS building (the guy whom Jobu turned into the salsa dancer) that was tied into it. They're going to be in jail, lose their jobs/business, and they won't have any memory (except for Evelyn) about what happened or why.
Similarly, even if Protagonist Verse Evelyn was able to give Alpha Jobu a new perspective on finding beauty in the here and now, and even if Jobu chooses to re-seal her mind and return to her own universe, she's going back to a universe where she's killed her parents, destroyed her world (no milk, etc.) and is generally regarded as a cosmic horror entity.
There's no real hint in the ending that it's possible (or desirable) to re-seal their minds. This answers both the above horrors; Evelyn or Jobu, if they visit those universes, can use their powers to make things all right. More specifically, they can make a version of the timeline where things are all right. Per the movie's premise, we can assume there is a version of themselves where they decide to make things all right, and a version of themselves where they don't. It's not possible to actually prevent any suffering, as there will always be versions where things are not all right (because every possibility necessarily exists and this cannot be changed). In fact, the conclusion of the film is learning to live with this, and finding meaning in whatever way one can.
Regardless of anything else that happens, while the characters we see on screen may have a "happy" ending, by definition there exists an infinity of universes where the characters are not happy, but rather meet an infinity of horrifying fates. Think of the absolute worst thing possible to happen to a person: it's happening to these characters an infinite amount of times. We just don't see them because the film isn't about them. As previously mentioned, this infinite suffering can never be changed or prevented because all paths already exist in infinite variety. One has no choice in the decisions one makes, because all decisions must necessarily be taken. Any "choice" is an illusion and nothing can ever be changed. The best one can do is acknowledge this fact while learning to ignore it.
