The 20th Century Logo being seen in The Void, alongside other characters related to the X-Men Film Series, is a reflection of meta-humor for Disney. Not only did they "prune" all of 20th Century Fox, but they essentially pruned their incarnation of the X-Men franchise as a whole.
This also leads to a bit of Fridge Horror too. If characters from the X-Men movies are seen in the Void, does that mean that there are other characters from 20th Century Fox movies who were sent to the Void after Disney acquired the studio?
Wade declares himself "Marvel Jesus", which on the surface seems like an arrogant boast, but it has a meta meaning, which, as a frequent fourth wall-breaker, he would know about. This movie has reignited some interest in a franchise that has been struggling with a flagging reputation as of late. Thus, Wade isn't quite so arrogant to call himself the Messiah of Marvel movies.
In the official trailer, Wolverine is daring Deadpool to put a bullet between his eyes, which should only affect his flesh thanks to his adamantium... except that that part of his skull should have been weakened by an adamantium bullet. Granted he does get shot there in X2, but this one's at point blank range...
The trailer shows that there's a variant of Giant-Man who died in combat, and whose corpse is being used as a living hub of sorts for survivors in the Void. This indicates that there may be an alternate universe where Scott lost against Kang the Conqueror, or alternatively, was pruned by the TVA for doing something wrong against Kang before the events of Ant-Man and the Wasp: Quantumania.
