- Subverted in Arrested Development. Michael briefly dates a beautiful heiress whose sinister uncle controls her money band refuses to let her see Michael. It's later revealed that she has the mind of a kindergartener and her uncle is her concerned guardian. He controls her money because she's not competent to use it, and keeps her away from Michael because she doesn't have the capacity to consent.
- Belgravia: Charles Pope has two.
- Oliver Trenchard (the brother of Charles' mother). Admittedly Oliver doesn't know Charles is his nephew and vice versa, but he does know that his father James is providing Charles funding for his company and advice on how to run business. Oliver envies Charles for having everything that he knows he lacks, believing he will be displaced as James' heir, and tries to drum up Malicious Slander against Charles. In the end he winds up subverting the trope when his conscience makes him go back and save Charles and James from drowning.
- Great uncle Stephen, the younger brother of Charles' paternal grandfather. Similar to Oliver, Stephen doesn't know of Charles' true background, but he knows that his sister-in-law Lady Brockenhurst is also funding Charles' business. Stephen, who has massive gambling debts, seeks to blackmail Lady Brockenhurst to pay off his debts with the help of his son John (who fits under Clashing Cousins).
- Subverted technically, in Blackadder's first season, which is set in an Alternate History where Richard III was a kind and loving uncle who was succeeded by one of the Princes in the Tower, Richard the Fourth, and the Evil Uncle and double murder history recorded was the result of a later king going back and falsifying records. That said his nephew was a homicidal maniac who suggested using his own son as arrow fodder and he was doting and supportive of him so he was not a much better king otherwise.
- Cathedral of the Sea: Grau Puig, a greedy merchant who married into the nobility. He profits from slavery, commits murder, and made his orphaned nephew a servant.
- Criminal Minds: The episode, "Seven Seconds," had an evil uncle and an evil aunt, with the latter being the Villain of the Week. As revealed in the episode, the uncle had been molesting his niece, and the aunt decided to kidnap and attempt to kill her niece out of jealousy.
- Justin Morningway from The Dresden Files. Among dear old Uncle Justin's crimes: arranging for his sister Margaret's murder ("she had dangerous ideas!") and, some years later, killing his brother-in-law with a voodoo doll in order to get custody of his magically gifted eleven-year-old nephew, whom he, with the help of a necromancer's cursed ghost, hoped to turn into a loyal political ally and supporter steeped in Black Magic. Oh, and let's not forget that although this failed spectacularly, Uncle Justin left behind a doppelganger who resurrected the necromancer and then forced the necromancer to steal the nephew's life force and implant it in Morningway's corpse.
- Game of Thrones:
- Deconstructed by Stannis and Renly Baratheon, who contest their nephew's claim to the throne. However, Joffrey is The Caligula and neither the rightful king nor their nephew. Besides it takes more than just wanting to depose him to make them "evil." However, though this is downplayed in the show Renly was willing to usurp who he believes was his nephew from the Iron Throne before Ned revealed their illegitimacy. Granted, Joffrey was a monster, but by supporting the rumor of their illegitimacy, Renly and Stannis were also willing to disgrace Myrcella and Tommen. Played straight with Stannis in Season 3, when he contemplates burning his biological nephew, Robert's bastard son Gendry, to gain magical advantage for his campaign.
- Played totally straight by Euron Greyjoy to Theon and Yara. He shows up to seize the throne of the Iron Islands by killing his brother Balon and usurping Yara's right to it, then planning to kill both of them to eliminate a threat to his power, but they manage to flee successfully. At first.
- Ellaria Sand is more than willing to have her innocent nephew Trystane assassinated in cold blood under the prospect that "weak men" like him will never rule over Dorne again.
- The Glamorous Imperial Concubine: Fu Ya's uncle usurps the throne and murders most of his family.
- Chuck's uncle Jack on Gossip Girl is definitely evil. He doesn't particularly mind if his seventeen year-old, newly orphaned nephew falls off the rooftop of a building and he delights in ruining said nephew's life a year later.
- Guardian: The Lonely and Great God: Eun-tak's aunt and cousins force her to do their chores, verbally and physically abuse her and try to steal Eun-tak's mother's life insurance.
- In Help! I'm a Teenage Outlaw, Sir John Snakelaw is Lady Devereux's uncle and legal legal guardian. He has commandeered her castle for his own use and keeps her a virtual prisoner within it while he schemes ways to take full possession of her fortune.
- In I, Claudius, Emperor Caligula is technically this before he becomes an Uncle. He impregnates his sister, but thinks he and his sister are Gods, so tries to imitate the birth of Athena by cutting the child out of her womb and eating it. Then there is his Great-Uncle Tiberius, who apparently murdered his nephew Germanicus, Caligula's Father, as he was more popular. It turns out that Caligula assisted with his father's murder and one of his henchmen ends up murdering Tiberius so Caligula can become Emperor.
- In From the Cold: Felipe and Andrés Calero to their nephews Rámon and Diego. They're either treated badly or worse drawn into terrorism.
- Justified: Johnny Crowder definitely has this opinion of his Uncle Bo, who crippled him with a shotgun blast to the gut. Of course, Johnny himself is a criminal who was setting Bo up to take the fall for his, and his cousin Boyd's actions, so while Bo's certainly evil, his attitude towards Johnny is fairly understandable.
- Legacies has Kai Parker, the Saltzman twins' maternal uncle, who killed their mother (his own twin sister) on her wedding day and was trapped in a prison dimension.
- The Legend of Xiao Chuo: Yelü Jing for Xian and Zhi Mo. He murdered their father and has Zhi Mo castrated
and partially blinded. After Jing's death his brother Yansage takes over this role and tries to overthrow Xian.
- Lost Love in Times: Yuan An plans to kill his nephew Yuan Ling. Made even more complicated because Yuan Ling grew up thinking Yuan An is his father, and he only discovers the truth as an adult.
- The Nennog of Maddigan's Quest was this to Timon, Eden and Jewel; it's made clear from the start he wants them dead. Well, Eden and Jewel, at least...
- Count Dregon was the main villain of Masked Rider and Prince Dex's uncle.
- As of Season 4, Prince Arthur from Merlin has his uncle Agravaine, who's secretly working with Morgana, partially in revenge for his sister dying birthing Arthur, and Arthur's father Uther killing his brother when they fought Uther over this.
- Superman & Lois has Morgan Edge, AKA Tal-Rho, Superman's half-brother. In season 1, he's the Big Bad who's trying to bring back Krypton by converting humans into Kryptonians. However, season 2 shows him slowly turning around and revealing that he's simply been trying to have a family he never did. By the end, it's clear that he sees Clark and his family as his own and is willing to risk his own life for them. In season finale, he buys Jordan and Jonathan their own pickup trucks, much to Clark's annoyance.
- The Tales from the Crypt episode "Fitting Punishment" centres around a homeless, orphaned teenager being sent to live with his miserly uncle. The uncle treats him as slave labour, cripples him for life during a beating, and then murders him after deciding that the boy is costing him too much money. Eventually the boy returns as a zombie and beats his uncle to death.
- The primary antagonists of the first season of Teen Wolf and the fourth season as well are Derek's evil uncle Peter, who wants to subdue everybody under his alpha powers, and Allison's evil aunt Kate, who kills innocent people in contrast to the more lawful Hunter's Code. In contrast, the major parents shown in the series (Scott's mom, Stiles's dad, Allison's father) are strictly on the side of good.
- In Trail of Lies, Felix Khoury is to his niece Paulinha at first, considering that he abandoned her in a trash bin when she was just a newborn, just because he didn't want to have to compete with anyone for his inheritance.
- None of the elder Marquezes in Velvet are particularly good people, but Pilar plays this role most directly in her efforts to destroy the Galerias Velvet and prop up her own department store.
- The White Queen: Played with. The show portrays Richard III as being in the right about his nephew being illegitimate and the throne being his, and he is not the one who has his nephews murdered. However, Richard is also portrayed as not only a stranger to young Edward V but also an intimidating and sinister figure who, from the boy's point of view, is a villain who has robbed him of his birthright on a technicality.
