Ok, they lost in the end, but the Skylanders kicking butt and taking names against Kaos' army was just epic! Even more so because there was actually teamwork involved.
A villainous example; Kaos actually manages to destroy the Core Of Light and defeat all the Skylanders on his first attack. He might be an Invader ZimExpy, but he's a lot more competent.
The Dragon's Peak bonus level has one. As you confront the level's Big Bad, Vathek, everything prepares for a boss battle. Flavius, the dragon who came to take you to Dragon's Peak in the first place, takes advantage of Vathek being distracted and takes the throne, along with all the power it gave Vathek, which he uses to turn Vathek to stone.
The fight between the Giants and the Arkeyan King. After going on a Foe-Tossing Charge for his army of giant Mecha-Mooks, they end it with Crusher taking out his knee, followed by Eyebrawl blasting him in the face with his Eye Beams, then Ninjini tricking him into lodging the Fist of Arkus into the wall and then cuts into his arm with her swords. Swarm then launches Tree Rex at the King, who punches the king in the head hard enough to rip his weakened arm (and the Fist of Arkus) off and destroy him.
Any time a feat of strength is preformed by one of the giants, especially the moving of a floating island attached to a chain!
At one point, we see an entire galleon attached to a chain, which can be pulled closer in the same way as the miniature islands.