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Manuela saves both herself and Leon by deliberately using the T-Veronica's power for the first time, yet remaining in control when it's over.
What makes this moment truly awesome is her spiritual predecessor Alexia Ashford despite all her means and attempts never truly was in control of the virus and became a monster which ultimately brought about her destruction while Manuela was able to successfully bond with the virus in the end and maintain her human form.
Steve stays true to his word that he wouldn't kill Claire even after he was forcibly turned into a monster by the T-Veronica virus and successfully breaks free of Alexia's control to save Chris and Claire, all at the cost of his own life.