History YMMV / OsmosisJones

*** Even more Hilarious, [[WhatCouldHaveBeen Will Smith was considered for the role of Ozzy before Chris Rock was cast]].

* EvilIsSexy: Many people say they find Thrax attractive, because of his design, fashion sense, voice, and flirtatious manner.
** His frequent usage of ''"baby"'' definitely helps.

* LauncherOfAThousandShips: [[EvilIsSexy Thrax]]. Fans tend to ship him with either [[FoeYayShipping Ozzy]], a SelfInsert, or an OriginalCharacter. And many a {{Fanvid}} maker has made fan edit {{Crossover Ship}}s of him with just about any 2D [=Non/Disney=] animated film character you can think of, the most popular choices being [[WesternAnimation/TheSwanPrincess Odette]] and [[WesternAnimation/SinbadLegendOfTheSevenSeas Eris]].

* TheScrappy: Frank is seen as such for being such a despicably unlikable slob. Especially with how he [[TooDumbToLive casually disregards his own health]], his apparent apathy towards Shane's frustration, and Creator/BillMurray's emotionless performance. It doesn't help that the beginning of ''WesternAnimation/OzzyAndDrix'' has him [[AesopAmnesia going back to his old self-destructive habits]].

* NauseaFuel: The movie takes place inside and around a severely unhealthy and unhygienic person, so it unsurprisingly contains a ton of gross moments. [[NauseaFuel/OsmosisJones Enough to the deserve its own page]].

* TheScrappy: Frank is seen as such for being such a despicably unlikeable slob. Especially with how he [[TooDumbToLive casually disregards his own health]], his apparent apathy towards Shane's frustration, and Creator/BillMurray's emotionless performance. It doesn't help that the beginning of ''WesternAnimation/OzzyAndDrix'' has him [[AesopAmnesia going back to his old self-destructive habits]].

* TheScrappy: Frank is seen as such for being such a despicably unlikeable slob. Especially with how he [[TooDumbToLive casually disregards his own health]], his apparent apathy towards Shane's frustration, and Bill Murray's emotionless performance. It doesn't help that the beginning of ''WesternAnimation/OzzyAndDrix'' has him [[AesopAmnesia going back to his old self-destructive habits]].

* JerksAreWorseThanVillains: Frank is deeply unpopular among viewers due to being quite unlikable and lethargic, with the most notable example being his emotionless reminder to Shane on how her mother died. He's actually more disliked than Thrax, who is seen as an [[EvilIsCool incredibly cool villain]] despite [[CompleteMonster his utter depravity]], and Mayor Phlegmming, who, unlike Frank, [[HateSink was actually meant to be hated by audiences]].

* CultClassic: Generally regarded as a dud with too many unfinished or poorly-realized ideas, it otherwise has a decent fanbase of nostalgic millennials who love it for what it is. The fact that it's one of the few theatrically released 2D-animated features from UsefulNotes/TheMillenniumAgeOfAnimation certainly helps.

* AudienceAlienatingPremise: For once, it was this and not a lack of advertisement on [[Creator/WarnerBros WB]]'s part that caused the film to flop. The film couldn't blend the live-action gross-out comedy with the animated buddy cop movie as each portion only detracted from the other, confusing audiences who were put off with the jarring juxtaposition of the two ideas in trailers.

* VindicatedByHistory: Even though it got bad reviews when it came out, it gained a loyal following among the nostalgia crowd for the strong animated scenes. It has also gotten fairly popular among those in medical professions for its surprisingly accurate depiction of the human body.

* NarmCharm: As the City of Frank collapses, there is a weird parody of the band from ''Film/{{Titanic|1997}}"" as Frank's body dies, including a performance of "Nearer My God to Thee". Yet, it comes across as a strangely moving homage in a very heartwrenching scene.

* AudienceAlienatingPremise: For once, it was this and not a lack of advertisement on WB's part that caused the film to flop. The film couldn't blend the live-action gross-out comedy with the animated buddy cop movie as each portion only detracted from the other, confusing audiences who were put off with the jarring juxtaposition of the two ideas in trailers.

* NarmCharm: As the City of Frank collapses, there is a weird parody of the band from Titanic as Frank's body dies, including a performance of "Nearer My God to Thee." Yet, it comes across as a strangely moving homage in a very heartwrenching scene.

* JerkassWoobie: Mrs. Boyd is a very cold and bitter teacher to the point where she'll [[HairTriggerTemper scream her head off at her students]] if they aren't doing their work, and she slapped Frank with a restraining order for simply vomiting on her at the school science fair. But, considering that she and her children were also humiliated after the incident, to the point where they were endlessly teased for it and her daughter Shirley even had to transfer schools and was given the nickname "Hurley", she obviously took out a restraining order on Frank to prevent further humiliation to her and her family, and her becoming such a cold and bitter person was clearly the result of all that endless humiliation.

* ParanoiaFuel: There's a lot in this film. Firstly, your body is made up of millions of fully conscious Cell Individuals; talking, crying, and living their millions of lives ''within you'' as you live about yours. Every time you cut yourself and blood drips out, that's a couple thousand people ''dying''! Also, related to the FridgeHorror, your Mayor (with approval from the City Council) has the ability to take over your brain and make you say and do things beyond your control.

* TheScrappy: Frank is seen as such for being such a despicably unlikeable slob. It doesn't help that the beginning of ''WesternAnimation/OzzyAndDrix'' has him [[AesopAmnesia going back to his old self-destructive habits]].

* AudienceAlienatingPremise: For once, it was this and not a lack of advertisement on WB's part that caused the film to flop. The film couldn't blend the live-action gross-out comedy with the animated buddy-cop as each portion only detracted from the other, confusing audiences who were put off with the jarring juxtaposition of the two ideas in trailers.

* JerksAreWorseThanVillains: Frank is deeply unpopular among viewers due to being quite unlikable and lethargic. With the most notable example being his emotionless reminder to Shane on how her mother died. He's actually more disliked than Thrax, who is seen as an [[EvilIsCool incredibly cool villain]] despite [[CompleteMonster his utter depravity]], and Mayor Phlegmming, who, unlike Frank, [[HateSink was actually meant to be hated by audiences]].

* JerksAreWorseThanVillains: Frank is deeply unpopular among viewers due to being quite unlikable and lethargic. With the most notable example being his emotionless reminder to Shane on how her mother died. He's actually more disliked than Thrax, who is seen as an [[EvilIsCool incredibly cool villain]] despite [[CompleteMonster his utter depravity]], and Mayor Phlegmming, who unlike Frank, [[HateSink was actually meant to be hated by audiences]].

* JerksAreWorseThanVillains: Frank, as mentioned in TheScrappy below, is deeply unpopular among viewers due to being quite unlikable and lethargic. With the most notable example being his emotionless reminder to Shane on how her mother died. He's actually more disliked than Thrax, who is seen as an [[EvilIsCool incredibly cool villain]] despite [[CompleteMonster his utter depravity]], and Mayor Phlegmming, who unlike Frank, [[HateSink was actually meant to be hated by audiences]].

* TheScrappy: Frank is seen as such for being such a despicably unlikeable slob. It doesn't help that at the beginning of ''WesternAnimation/OzzyAndDrix'' [[AesopAmnesia he is shown back to his old self-destructive habits]].

* TheScrappy: Frank is seen as such for being such a despicably unlikeable slob to the point that many have noted that his daughter, Shane, would probably have been better off if Frank actually did kick the bucket. It doesn't help that at the beginning of ''WesternAnimation/OzzyAndDrix'' [[AesopAmnesia he is shown back to his old self-destructive habits]].

* UnintentionallyUnsympathetic: Shane may have every reason to be telling her father how to improve his heath, but her RightlySelfRighteous attitude makes her seem less concerned and more like an annoying little smarty pants.

* JerksAreWorseThanVillains: Frank, as mentioned in TheScrappy below, is deeply unpopular among viewers due to being quite unlikable and lethargic. With the most notable example being his emotionless reminder to Shane on how her mother died. He's actually even more hated than Thrax, who is seen as an [[EvilIsCool incredibly cool villain]] despite [[CompleteMonster his utter depravity]], and Mayor Phlegmming, who [[HateSink was meant to be hated to begin with]].

** "Why you hit so hard?" [[labelnote:Explanation]] This line is uttered by Osmosis Jones after he gets punched by one of Thrax's goons. It gained some traction following Jones' voice actor Creator/ChrisRock getting slapped by Creator/WillSmith at the 2022 [[UsefulNotes/AcademyAwards Oscars]].[[/labelnote]]
** You can't fuck Osmosis Jones. [[labelnote:Explanation]]A Tumblr user of the same name made a post explaining how it would be impossible to have sex with Osmosis Jones due to his microscopic size. [[https://youtube.com/watch?v=ipf9MBuurv4 Other users replied]] with suggestions on how it would actually be possible if one tried hard enough. This conversation is often brought up whenever Osmosis Jones is mentioned on Tumblr.[[/labelnote]]

* EpilepticTrees: There are multiple fan theories on what Thrax is.

* JerksAreWorseThanVillains: Thrax, even with his sadistic and dark personality and actions, is much more of an entertaining and fan-loved villain than Mayor Phlemming, who caused Frank's health problems to start, puts his re-election above anything else, refuses to do anything against Thrax, and treats both Osmosis and Drix with disdain.

* CompleteMonster: [[DiseasedName Thrax]] is a [[MonstrousGerms deadly virus]] who is [[FameThroughInfamy obsessed with infamy and making his name known in the medical books]]. To this end, Thrax infiltrates human after human and slowly kills them through an agonizing fever--one of his victims a [[WouldHurtAChild little girl]] who "didn't like to wash her hands"--which comes with the consequence of killing both the human and every living organism inside of them. Upon invading the body of Francis "Frank" [=DiTorre=], Thrax [[EstablishingCharacterMoment introduces himself]] by burning a cell unfortunate enough to cross him from the inside out whilst humming, and cuts clean through a local crime boss to cow his flunkies into serving him. Thrax sets about murdering whomever comes in his way and burns his own flunkies to death after they suggest incubating, ultimately nearly succeeding in dooming Frank and gloating to hero Osmosis Jones that he intends on breaking his record on Frank's young daughter Shane.

** Tom Colonic has been getting some comparisons to 2020 Democratic Presidential Candidate Beto O’Rourke.

** Ozzie and Thrax get a lot of FoeYayShipping, especially with this line from the latter -

* MemeticBadass: Ozzy is seen as a hardcore cell after Covid-19 arrived. Helps that his current voice actor said in a Cameo video "Corona is gonna be a gonna."

** "Why you hit so hard?" [[labelnote:Explanation]] This line is uttered by Osmosis after he gets punched by one of Thrax's goons. It gained some traction following Jones's voice actor Creator/ChrisRock getting slapped by Creator/WillSmith at the 2022 Oscars.[[/labelnote]]

** Frank eating a Circus Peanut while trying to have a moment with his daughter about her mother passing away is such a pathetic sight that you can't help but laugh at it, which is also especially not helped by Bill Murray's apathetic performance in that scene. It's often seen as a low point for Bill Murray, who's otherwise a fantastic actor.

* TheScrappy: Frank is seen as such for being such a despicably unlikeable slob to the point that many have noted that his daughter, Shane, would probably have been better off if Frank actually did kick the bucket. It doesn't help that at the beginning of ''WesternAnimation/OzzyAndDrix,'' [[AesopAmnesia he is shown back to his old self-destructive habits]].