History Main / ImmortalityInducer

** The Lazarus Pits used by ComicBook/{{Batman}} archfoe Ra's al Ghul and others can rejuvenate the dying. Ra's Al Ghul is hundreds of years old thanks to the Pits.

* The Lazarus Pits used by ComicBook/{{Batman}} archfoe Ra's Al Ghul and others can rejuvenate the dying. Ra's Al Ghul is hundreds of years old thanks to the Pits.
* ''ComicBook/BatmanEndgame'' reveals that "Dionesium" is responsible for the apparent immortality and healing factors of several characters in the DC universe: Ra's Al Ghul via the Lazarus Pits, Vandal Savage, [[spoiler:the Court of Owls' Talons, and the Joker.]]

* ''Comicbook/FantasticFour'' villain Annihilus has severe MortalityPhobia, so he mainly uses the Cosmic Control Rod to halt his aging. The other powers the Rod possesses also make him generally very difficult to hurt or kill by other means, too.
* [[ComicBook/{{Bloodstone}} Ulysses Bloodstone]] is immortal because of a meteorite/gem shard stuck in his chest. At the end of his story, it gets surgically removed by some bad guys and he dies.
* ComicBook/NickFury stopped aging thanks to the Infinity Formula. His ArchEnemy Baron Strucker is also immortal thanks to the Death Spore and other serums HYDRA used on him.
* The Sphinx, an enemy of ComicBook/{{Nova}}, was an Ancient Egyptian Priest given immortality and great powers by a gem he found in a mysterious temple. But he came to [[WhoWantsToLiveForever regret living for thousands of years]]; his main motivation was to find a way to end his own existence.
* In ''ComicBook/RequiemVampireKnight'', everyone in Résurrection [[MerlinSickness ages backwards, turning into babies rather than growing old]]. The only thing capable of preventing that is {{Dracula}}'s dark kiss, which on top of preventing people from aging, grants them an incredibly powerful HealingFactor. Its not very easy to come by, specially since Thurim, one of the previous vampires that gained the kiss, tried to overthrow Dracula in the past and it was nearly impossible to put him down afterwards.
* ''ComicBook/{{Royals}}:'' Primagen can, in addition to supercharging the powers of any Inhuman who touches it, can boost their lifespan by several thousand years. [[spoiler:Maximus manages to live fifty thousand years thanks to being exposed to a tiny sliver.]]

* ''ComicBook/SupermanAndBatmanGenerations'': There is a pool that makes a person submerged in it immortal, but two people have to enter together and one of them will die.
* One anthology issue of ''ComicBook/TheTombOfDracula'' featured a underground pool of blood that made any mortal contacting it immortal.
* ComicBook/VandalSavage was a Cro-Magnon man named Vadar Adg who found a strange meteorite that fell to Earth one cold night. He fell asleep near it, being bathed in its rays during the night, and he woke up an immortal being. However, the meteorite's effects aren't permanent; Vandal occasionally needs to eat the flesh and organs of his own descendants to maintain his immortality. That bit is NewerThanTheyThink, added after the appearance of the immortal character with the same weakness in ''Series/{{Smallville}}''. Before that, he had to transplant organs from his descendants into himself as they wore out. Yes, this has scientific problems.
* ComicBook/SheHulk once had a skrull for a companion that swallowed a magic gem that gave her ResurrectiveImmortality.
* An old anthology from Marvel comics had a scientist build a device that used electricity to induce immortality. Unfortunately, the twist ending involved a second hit undoing it just as he suffered a fatal wound. Another had a man develop a serum that granted immortality but also cause deforming mutations into a durable monster.

** In ''Return to Ravenhearst'', it is revealed that Charles Dalimar [[spoiler:created a machine that kept him alive for more than a century by using the power of other people's souls.]]
** In ''Broken Hour'', Jacob Huxley invented a mechanical heart that gave immortality to the people it was implanted in. To bad it went horribly wrong when he implanted it [[spoiler on his wife, who pretty much ''wanted'' to die, and went insane because of her new immortality]].

* In ''Franchise/DragonBall'', one of the wishes the Dragons can grant is bestowing immortality. The early villains of ''Z'', Vegeta and Frieza, wanted Earth and later Namek's Dragon Balls for this reason. Though Vegeta only sought them out [[spoiler:because he believed he would only be able to defeat Frieza if he was immortal. He lost interest in immortality after Frieza was defeated.]] The only character known to have achieved immortality this way is Garlic Jr., who seems to have gained CompleteImmortality from it. Unfortunately for him, he was also HoistByHisOwnPetard and sucked into a pocket dimension [[AndIMustScream where he remains indefinitely]]. The sequel series ''Super'' [[spoiler:introduces Future Zamasu, who ''succeeded'' in getting this from the Super Dragon Balls, and like Garlic Jr. received CompleteImmortality.]]

* The Slates made Adolf ''Anime/{{K}}''. Weismann immortal when he became the Silver King. Subverted in that he didn't want it -- he would rather have died in the bombing [[AngstySurvivingTwin along with his sister]]. [[spoiler: In the end of the second season, he does destroy the Slates and lose his immortality. He now gets to live a normal life with Kuroh and Neko.]]

* In the ''Fanfic/PonyPOVSeries'':

* The Time Stone did this to [[spoiler: Stephen Strange]] in the backstory of ''FanFic/ChildOfTheStorm,'' as well as making him a true TimeMaster. Even he isn't entirely sure why.
* ''Fanfic/QueenOfShadows'': It's revealed during the climax of the Battle of Tobe that [[spoiler: Lord Rokutaro]] has a crystal shard impaled into his chest which gives him a powerful HealingFactor. With it, he survives being cut in half at the waist, but dies as soon as it's removed by Kamisori.

* ''Literature/{{Animorphs}}'': During one of their several TimeTravel adventures, the team sans Jake are given this as part of two godlike characters' game. [[spoiler: The Ellimist exploited the ExactWords of the deal Crayak made to send the gang through time to chase Visser Four. Crayak demanded one life as payment, so he ''only'' got one: once Jake was killed, the others become Jack Harkness-esque immortal, instantly reverting to normal after damage no matter how [[ChunkySalsaRule chunky salsa-ified]] they get.]]
* The Grand Panacea from ''Literature/{{Baccano}}'' has this effect; anyone who drinks it ceases aging and [[GoodThingYouCanHeal almost immediately]] recovers from any injury (seriously, if they're burned the ash turns right back into flesh). The only way to "kill" an immortal is for another to [[IdentityAbsorption absorb]] them (which gives them their memories in the process). There's also lesser versions of it that grant invulnerability and the weakness to being absorbed but not immunity to aging. According to the novels, immortals are actually immune to fire and acid, not just able to recover from it. Szilard's research has shown that their individual cells are completely indestructible and anything that involved breaking down things on a cellular level such as burning (or acid), won't actually do anything to them. The damage that fire/acid does to the outer portion of their cells is so small it regenerates instantly resulting in immortals that don't give off smoke while on fire since their cells don't even have time to turn into ash, and fires that will burn literally forever as long as they have enough heat/oxygen to keep the reaction going since the immortal's body provides unlimited fuel. That's not to say it doesn't hurt them, since their nerves can still sense the heat and register it as pain.

** [[EvilOverlord The Lord Ruler's]] bracers in ''Literature/{{Mistborn}}'', which work due to the fact that [[spoiler: he's a master of two metal-based magic systems which have odd interactions between them]]. They're made of [[{{Unobtainium}} atium]] which [[spoiler: the Lord Ruler can use to store youth for later consumption using Feruchemy -- with the side effect that he has to become old for an equivalent amount of time that he's young, because Feruchemy is an EquivalentExchange system]]. Add his ''other'' magic system, Allomancy, which lets him draw power from the metal itself -- [[spoiler: by "burning" the bracers he's charged with Feruchemy, he's got a pair of magical objects that make him -- and only him- infinitely young]]. This neat trick is called "compounding", and was the source of his [[PhysicalGod godlike general abilities]], though only the bracers are this trope.
** The mistwraiths are normal mortal creatures but [[spoiler: once given two Hemalurgic spikes they gain sentience and become the immortal kandra.]]
* [[spoiler:Durzo Blint, and later Azoth/Kylar Stern gain immortality after bonding with the Black Ka'kari]] from ''Literature/TheNightAngelTrilogy'' by Brent Weeks.
* In ''Literature/{{Nightside}}'' a street vendor is selling immortality serum. The real deal. "One sip, and you'll live forever. [[note]]You'll be a frog, but you'll live forever.[[/note]]"
* ''[[Creator/CordwainerSmith Norstrilia]]'' and the other 'Instrumentality of Mankind' stories: Stroon, a compound extracted from the huge, diseased sheep on Norstrilia, can be purified into Santaclara, a single injection of which could extend life by hundreds of years. While the Instrumentality set a standard lifespan of 400 years, Norstrilians themselves often live over a thousand years.
* Cell activators in ''Literature/PerryRhodan'' are the AmuletOfDependency type in that once one has been worn for too long, the wearer will die from accelerated cellular decay after about 62 hours if they ever lose it. The benefits do, however, include lack of aging, a modest HealingFactor, and virtual immunity to all but the fastest-acting of poisons. The "classic" version was a literal amulet (a small egg-shaped pendant traditionally worn on a chain), which had the obvious drawbacks but also the advantage that it could be temporarily loaned to other characters to let them take advantage of its healing properties; the "modern" one is an implanted chip, which is rather harder to lose (without resorting to surgery, which some prospective thieves ''have'' tried) but also can no longer be used to help others in that fashion.

* Ritual from Literature/{{Repairman Jack}} novel ''The Haunted Air''. [[PoweredByAForsakenChild A living child heart has to be eaten between summer solstice and the autumnal equinox every year.]] After 29 times user stops aging and becomes immune to harm and diseases for as long as ritual is kept up. [[NoImmortalInertia Else...]]

* The Large Hadron Collider at CERN is jury-rigged to become an Immortality Inducer in ''[[Literature/ZeusIsDead Zeus Is Dead: A Monstrously Inconvenient Adventure]]'' via some material from Saturn's rings, some "really good fudge," and a few extra tweaks of [[spoiler: Zeus's power]].

* In ''Series/Forever2014'', while it's not entirely clear what caused Henry's ResurrectiveImmortality, it all started with him being shot by an 18th century pistol by a slave ship's captain (who, basically, shot his boss's son) while trying to protect a sick slave (it's later revealed that he was in the process of trying to free all the slaves on the ship). Much later, another immortal who calls himself Adam reveals his theory that the only way to stop the "curse" is to once again be killed by the same weapon that started it all. He gifts the same pistol to Henry to see if Henry has the guts to do it. Adam admits that, when he managed to re-acquire the same pugio (Roman dagger) that first killed him over 2000 years ago, he was unable bring himself to test his theory. [[spoiler:It doesn't work, although it may be because Adam is the one who pulled the trigger, not Henry]].
* ''Series/{{Ghosted}}'': The Cronos machine from in "The Machine". Created as a combination of [[{{Magitek}} science and magic]], it takes people's [[ThePowerOfBlood blood]], absorbing their LifeEnergy in the process, so it can be transferred into the machine's owner. This grants the owner {{immortality}}, [[SuperStrength superhuman strength]], and a HealingFactor so fast they're practically invulnerable, whilst the victims [[RapidAging age to dust]].

* ''Series/HouseOfAnubis'': The Cup of Ankh functions like this under very specific circumstances. One needs to drink the elixir of life from it at "the Chosen Hour", and the cup itself must be built by TheChosenOne. It once belonged to the Gods of Egypt, until Anubis' lover Amneris stole it. He got so angry that he broke it into seven different pieces, but gave the chance for it to be rebuilt- once every seventy-five years, a descendant of Amneris could rebuild the cup. The search for it, and the race to build it, is what drove the first season of the show.
* ''Series/KamenRiderExAid'' is primarily centered around a mad scientist's attempts to produce immortality after discovering a virus with the supernatural power to turn living beings into video game characters and the other way around. ProfessorGuineaPig is in full effect, and Kuroto gives himself three different flavors of immortality during the show, plus at least two more in sequel media.

** In ''Broken Hour'', Jacob Huxley invented a mechanical heart that gave immortality to the people it was implanted in. To bad it went horribly wrong when he implanted it [[spoiler: on his wife, who pretty much ''wanted'' to die, and went insane because of her new immortality.]]

* ''WebAnimation/BravestWarriors'' has the Ever Gauntlet, which keeps its holder(s) from aging. [[spoiler: It also halts all natural body functions, including healing, but all can be restored by just getting away from it.]]

* The life extenders are this for their holders in the ''VideoGame/TeamFortress2'' [[AllThereInTheManual supplemental webcomics]]: one for Blutarch Mann, the other for Redmond Mann. [[spoiler: The ''Loose Canon'' comic suggested that THREE were built. In fact, there are a total of four. One is used by the lost Mann brother, Gray, assumed to be the third although later developments suggest he actually built it himself. Everything he's done since showing up is to find [[{{Unobtainium}} Australium]] to [[ImmortalitySeeker keep it going.]] The final life extender, presumably the third original, is used by the Administrator and frequently upgraded by the Engineer, as revealed by ''Blood in the Water''.]] That same story however reveals that even the life extenders have their limits. [[spoiler:The Administrator's upgraded version will still only grant her a few more years.]][[note]]By the end of Issue 7 of the grand finale comics, she only has '''one hour'''[[/note]].

[[folder:Web Original]]
* In ''Webcomic/{{Jix}}'' Kelelder the Planet Thief was made immortal due to a glitch in a cloning and mind transfer device. He's also made a couple of servants immortal using his blood, Heleatra too due to a deal with Remula.
* From the Website/SCPFoundation, there's [[http://scp-wiki.wikidot.com/scp-963 SCP-963;]] a talisman which, if you are killed while holding it, is imprinted with your soul. From then on, anyone else who touches the talisman has their personality overwritten with whoever is contained inside. It's actually possible to make multiple copies of yourself this way.
** Unfortunately, SCP-963 currently belongs to the [[BunnyEarsLawyer quite-possibly-insane]] Dr. Bright, which led to several (actually pretty funny) restrictions such as "SCP-963 is not a joy-buzzer," "SCP-963 is not to be used in a game of 'hot potato'," and "Dr. Bright is not allowed to apply SCP-963 to any major political figures. Again."

** The episode "The Whirly-Dirly Conspiracy" takes place in a space resort covered in an immortality field. People just kill each other for fun and instantly heal from their injuries. The title "Whirly-Dirly" is a roller-coaster that briefly leaves the immortality field, allowing aliens to try and assassinate Rick, and the attempt to stop them causes the immortality field to be destroyed.
** The episode [="Final DeSmithation"=] has a temporary version in the form of [[spoiler: ordinary fortune cookies. Due to the cookies being made from the feces of a chaos-eating alien creature with an intestinal problem that draws the unknown towards known like gravity, any fortune inserted into the cookies is destined to come true, no matter how improbable. The immortality stems from how many fortunes are next-to-impossible to achieve while dead, so fate will keep whoever eats the fortune cookie alive until the prediction written on the fortune comes true. Rick exploits this by using Jerry as a meat shield due to his fortune of having sex with his mother not having come true yet, and in a big fight scene in the end, Rick ends up eating an ordinary fortune cookie that predicts he will make a new friend, rendering Rick immortal until he makes a new friend. The episode also features a guard who is given a fortune that says "You cannot be killed", providing a more direct version of this trope.]]

* The Font of Immortality (the drink, not the typing) is one of the five artifacts in ''Literature/{{Fablehaven}}''. The catch is that it must be drank from at least once a week (don't worry, it's infinite), or else the drinker will spontaneously [[NoBodyLeftBehind turn to dust]].

* In ''Literature/{{Gor}}'', humans have immortality thanks to "stabilization serums" - shots - developed by the Caste of Physicians; basically, it's an immunization against old age. In one book, a woman from Earth actually gets de-aged from her 60s to age 18 or so thanks to the serum. The priest-kings, alien gods of the planet, have even more advanced stabilization serums which make them immortal until they decide to die, although they can be killed.

* In ''Literature/TheLordOfTheRings'', the Great Rings (including the One Ring) all act as a particularly torturous version of this. Immortal beings such as Elves are not affected, obviously, while Dwarves are apparently immune. But a mortal who keeps one of the Great Rings, such as Gollum or Bilbo Baggins, stops aging. As befits an ArtifactOfDoom, it does not give its bearer new life, it stretches whatever lifeforce is remaining, resulting in AgeWithoutYouth. The Nine Rings given to the Nazgûl work in a similar way. It's not a pleasant experience however, as it makes you feel "sort of stretched, like... butter scraped over too much bread."

* In ''Literature/TheLordOfTheRings'', this is one of the things the One Ring can do. Gollum's unnatural age is thanks to it. The Nine for the Nazgûl also serve this function. It's not a pleasant experience however, as it makes you feel "sort of stretched, like... butter scraped over too much bread." As befits an ArtifactOfDoom, it does not give its bearer new life, it stretches whatever lifeforce is remaining, resulting in AgeWithoutYouth.

* The Lazarus Pits used by Franchise/{{Batman}} archfoe Ra's Al Ghul and others can rejuvenate the dying. Ra's Al Ghul is hundreds of years old thanks to the Pits.

* Franchise/MarvelUniverse's [[http://en.wikipedia.org/wiki/Ulysses_Bloodstone Ulysses Bloodstone]] is immortal because of a meteorite/gem shard stuck in his chest. At the end of his story, it gets surgically removed by some bad guys and he dies.

* She-Hulk once had a skrull for a companion that swallowed a magic gem that gave her ResurrectiveImmortality.

* Humanity has been searching for the secret to immortality for thousands of years. For some reason they kept coming back to UsefulNotes/{{Mercury}} as a miracle serum. Historians partially attribute the fall of several Chinese dynasties to emperors drinking mercury, going crazy, dying young and leaving the throne to unprepared boys, who grew up to drink mercury, etc.

* ''Film/AnacondasTheHuntForTheBloodOrchid'' has the namesake McGuffin the Blood Orchid. So-called because of its blood-red color, its regenerative properties greatly extend the lifespan of animals that feed on it. Because the predatory anacondas in turn feed on those herbivores, they inadvertently consume the same chemicals, and since [[StrongerWithAge reptiles continue growing into adulthood]]...

* The Grand Panacea from ''Literature/{{Baccano}}'' has this effect; anyone who drinks it ceases aging and [[GoodThingYouCanHeal almost immediately]] recovers from any injury (seriously, if they're burned the ash turns right back into flesh). The only way to "kill" an immortal is for another to [[IdentityAbsorption absorb]] them (which gives them their memories in the process). There's also lesser versions of it that grant invulnerability and the weakness to being absorbed but not immunity to aging.
** According to the novels, Baccano immortals are actually immune to fire and acid, not just able to recover from it. Szilard's research has shown that their individual cells are completely indestructible and anything that involved breaking down things on a cellular level such as burning (or acid), won't actually do anything to them. The damage that fire/acid does to the outer portion of their cells is so small it regenerates instantly resulting in immortals that don't give off smoke while on fire since their cells don't even have time to turn into ash, and fires that will burn literally forever as long as they have enough heat/oxygen to keep the reaction going since the immortal's body provides unlimited fuel. That's not to say it doesn't hurt them, since their nerves can still sense the heat and register it as pain.

* In Creator/UrsulaKLeGuin's ''Literature/ChangingPlanes'', one world that the narrator visits has an island which has a small population of immortals, whose eternal life is believed to be granted by the mosquitoes that are endemic there. Unfortunately, this is Type VI immortality, with a normal human ability to heal. The immortal that she is fortunate enough to meet is a withered husk after having survived falling into a lava stream. The natives don't seem to worry about this fate because, according to them, [[spoiler:there is just one]].

* Franchise/ConanTheBarbarian:
** In Creator/RobertEHoward's ''Franchise/ConanTheBarbarian'' story ''Literature/TheTowerOfTheElephant'', Yara is said to be centuries old, and immortal because of his [[MineralMacGuffin gem]], the Heart of the Elephant.

** [[EvilSorcerer Fistandantilus's]] bloodstone pendant allowed him to drain the life-force from other wizards to prolong his own existence. [[spoiler: Unfortunely for him, his BastardUnderstudy Raistlin figured out that he would be the next victim and turned the tables, stealing the bloodstone and using it on Fistandantilus himself, killing him, absorbing his memories and life-force, and stealing his identity to boot]].

* The Denarians in ''Literature/TheDresdenFiles'' are immortal due to the presence of the {{Fallen| Angel}} contained in [[ThirtyPiecesOfSilver the silver denarius coin]] each one carries. Furthermore, Nicodemus is given extra protection by the fact that he wears the noose Judas Iscariot supposedly used to commit suicide around his neck, which allows him to regenerate damage that would drop even other Denarians who are protected by their respective Fallen. [[spoiler:However, the noose itself can kill him.]]

* Both Yukiko and Liselotte Werckmeister from ''VisualNovel/ElevenEyes'' share the same immortality that comes with an rapid HealingFactor and [[TheAgeless the inability to age]]. It is revealed that the Voidstone is the source of the immortality and separating it from the host will disable that immortality.

* In ''Series/DoctorWho'', despite regaining a set of regenerations, the John Simm version of the Master forces himself not to, storing his essence inside a ring to revive himself later.
** Similarly, the Kastrian Eldrad was blown into a single hand. He and his entire race could store their genetic imprint into a ring to be reawakened with a burst of radiation even after over a hundred million years.
** Then there's the Time Vortex, which can do virtually anything. When Rose absorbs it, she uses it to revive the recently-killed Captain Jack Harkness. However, since she is an inexperienced "Time Goddess", she ends up reviving him ''permanently'' (essentially setting his "revive" setting to "always on"). Nothing can kill him (except for [[spoiler: the Blessing which makes him mortal again, overriding the Time Vortex, or rather flip-flopping it: Everyone else gets his immortality and Jack becomes temporarily mortal]]). He also may die about five trillion years in the future, depending on whether or not he actually is [[spoiler: the Face of Boe]].
** After witnessing the death of a young Viking girl name Ashildr in "The Girl Who Died," the Doctor cobbles together some alien tech which he implants in her head; the good news is she comes back to life. The not-so-good news: she loses the ability to die and, while a severe enough injury could still kill her, she ultimately lives on for ''trillions'' of years.
** At the end of Series 9, [[spoiler: Clara Oswald]] is rendered immortal as a result of being extracted from time a moment before her death. Most of her body processes are frozen (though she can still think, move around, express emotion and cry and even drink) and she no longer ages. However, this status is indicated as only being temporary -- if she doesn't die as history marks, a RealityBreakingParadox will result, but nothing says it can't be after spending hundreds, thousands, or even millions of years of tooling around the universe in her time-displaced state.
* In ''Series/{{Forever|2014}}'', while it's not entirely clear what caused Henry's ResurrectiveImmortality, it all started with him being shot by an 18th century pistol by a slave ship's captain (who, basically, shot his boss's son) while trying to protect a sick slave (it's later revealed that he was in the process of trying to free all the slaves on the ship). Much later, another immortal who calls himself Adam reveals his theory that the only way to stop the "curse" is to once again be killed by the same weapon that started it all. He gifts the same pistol to Henry to see if Henry has the guts to do it. Adam admits that, when he managed to re-acquire the same pugio (Roman dagger) that first killed him over 2000 years ago, he was unable bring himself to test his theory. [[spoiler:It doesn't work, although it may be because Adam is the one who pulled the trigger, not Henry]].

* ''Series/{{Space 1999}}'' episode "The Exiles". Two prisoners have extended lifespans due to skintight membranes covering their bodies. If the membrane is ripped and their bodies are exposed, they're subjected to RapidAging and die.
* Goa'uld sarcophagi in ''Series/StargateSG1'' are best described as {{Autodoc}}s, but they're so effective that they can ''raise the dead''. The System Lords are thousands of years old thanks to them. Shame about the [[WithGreatPowerComesGreatInsanity side effects]].
** As evidenced by Lord Yu, even a sarcophagus can, eventually, prove useless, if a symbiote is extremely old. Yu is shown to be suffering from the Goa'uld version of senility, such as ordering fleets to a battle that was fought long ago. His [[NumberTwo First Prime]] complies, of course, but then conspires with Teal'c to turn command of the fleets over to [[MagnificentBastard Ba'al]]. Ba'al is, at first, outraged that a First Prime would betray his god, but relents after Teal'c suggests offering the deal to a rival System Lord.

* The Heart of Chaos serves this purpose for Caius of ''VideoGame/FinalFantasyXIII2''. As long as it beats in his chest, he always revives instantly after being defeated, {{Justified|Trope}} via him having the Auto-Raise status boost. If it's destroyed, he dies [[spoiler:and so does the goddess who gave it to him.]]
* The TropeNamer is the +ii emitter in ''Videogame/IMissTheSunrise'', affectionately referred to as the "immortality inducer" by some characters. It works by emitting radiation that stops cell aging, and is mass-produced, effectively making the entire human race immortal. It induces type II immortality.
** In the sequel, ''VideoGame/TheReconstruction'', it is also [[spoiler:the "artifact" that Havan finds. Tezkhra reveals in the GoldenEnding that there are five in total. Four are destroyed or deactivated by Tezkhra, so the fifth is likely a SequelHook.]]
* ''Franchise/TheLegendOfZelda''

* In ''VideoGame/MetalGearSolid4GunsOfThePatriots'', [[spoiler:Vamp, who previously demonstrated his immortality in ''VideoGame/MetalGearSolid2SonsOfLiberty'', is revealed to have nanomachines [[DoingInTheWizard (what else?)]] in his body that enhance his already impressive [[HealingFactor natural healing abilities]], making him practically immortal. Naturally, the only way to beat him later on is to inject him with a shot that supresses his nanomachines.]]

** In ''VideoGame/PokemonXAndY'', [[spoiler:the Ultimate Weapon]] can grant eternal life.
*** The Pokemon Xerneas grants eternal life, too, but not when you catch it in a Pokeball. [[StupidityIsTheOnlyOption Guess what you do over the course of the game.]]

--> This Witherless Rose will wither away instead of you...\\

* ''VideoGame/RiseOfTheTombRaider'' introduced another one to the series: the Divine Source, as evidenced by [[spoiler:Jacob, who's the very same prophet that led his followers from Constantinople to Siberia many centuries before Lara meets him, still looking the same as he did then]]. The Source, taking the shape of head-sized, [[PowerGlows glowing blue]] crystal, also grants immortality by removing the soul of anyone who gazes into it, both in terms of [[TheAgeless not aging anymore]] and gaining ResurrectiveImmortality. Unfortunately, questions as to the Source's origin or true nature are left a RiddleForTheAges.
* Miss Fortune of VideoGame/{{Skullgirls}}, upon swallowing the Life Gem. She was cut into pieces shortly afterwards, though not only did she survive the ordeal, the gory extent of splitting apart her undying body is utilized in her fighting style.
* The Twenty-seven True Runes in the ''VideoGame/{{Suikoden}}'' games will stop their bearers from aging.
** However, given the nature of the True Runes, you're more likely to die just by ''having one''.
* [[spoiler: Jacob Crow]] in ''VideoGame/TimeSplittersFuturePerfect'' achieves immortality by merging himself with one of these, or turning himself into one, it would seem. The good? He is immortal and can time-travel at will. The bad? His [[BodyHorror body is plastered to a giant bipedal mech, and he has absolutely no hands whatsoever]].
* The Eye of Isis artifact in ''VideoGame/TombRaiderIII'' can apparently grant its bearer immortality or at least have drastically slow aging. Cosmetics tycoon Sophia Leigh posses the Isis and uses it in conjunction with her experiments to get true everlasting beauty. Unfortunately, all the people she experimented on were LeftForDead after their face and flesh rotted away and got booted down to the abandoned train tubes of Aldwych. When the men who were affected by the experiment tried to kill themselves, they discovered that it didn't work because they became immortal.
* The ''VideoGame/{{Touhou}}'' series has the Hourai Elixir, which was literally created by distilling the concept of eternity into liquid form. It makes whoever drinks it immortal by removing the very concept of death from their being: they will never age, never grow sick, and will heal any injury, no matter how severe (even ''instantly'' in Kaguya's case, due to her other power). The closest one can get to defeating one is beating them down until the pain makes them not want to fight you anymore. Even if you could time-travel to before they drank the elixir and tried to kill them then, it ''still'' wouldn't work; death was removed from the ''entirety'' of their history. Fortunately, only three (possibly four) people have consumed the Elixir, and not one of them is particularly interested in a fight to the death ([[CycleOfRevenge except between]] two [[RevengeBeforeReason of them]]). The Elixir remains in the immortal's body -- should someone be skilled enough to disable a Hourai immortal and eat his or her liver without cooking it, they will also be granted the effects of the Elixir.

* ''VideoGame/WarGods'' features a mystical stone known as the Ore. Induces eight humans, one cyborg and one stone idol to immortality thanks to many chunks of ore. As a result, [[ThereCanBeOnlyOne they're fighting each other until one becomes the true superior God]]... ([[ExcusePlot or so it seems.]])

[[folder:Web Comics]]

* ''[[Creator/CordwainerSmith Norstrilla]]'' and the other 'Instrumentality of Mankind' stories: Stroon, a compound extracted from the huge, diseased sheep on Norstrilla, can be purified into Santaclara, a single injection of which could extend life by hundreds of years. While the Instrumentality set a standard lifespan of 400 years, Norstrillans themselves often live over a thousand years.

* This was said to be one of the many effects of the Philosopher's Stone.

* In Myth/ChineseMythology, the Peaches of Immortality grow in the garden of the Jade Emperor of Heaven and are given to gods, sages and others deemed worthy of them.
* In Myth/GreekMythology, the food of the gods grows on Mt. Olympus and grants their immortality.
* In Myth/HinduMythology, the nectar of Immortality called Amrita came from the buttery substance that both gods and devils made when they stirred the primal ocean.
* In Myth/JapaneseMythology, Ningyo or Mermaid flesh was said to give near infinite vitality unto the eater.
* In Myth/NorseMythology, the gods maintain their immortality by the eating of golden apples cultivated by the goddess Iðunn. You might be noticing a pattern here.

* In Myth/HinduMythology, the nectar of Immortality called Amrita came from the buttery substance that both gods and devils made when they stirred the primal ocean.

* In Myth/JapaneseMythology, Ningyo or Mermaid flesh was said to give near infinite vitality unto the eater.

* In Myth/ArthurianLegend, the scabbard of Excalibur is implied to be this. While it's not ''explicitly'' said to grant immortality, as long as Myth/KingArthur had it in his possession he was effectively safe from ever being wounded or killed in battle. Some versions of the myth even go so far as to say that it could heal sickness or even slow/prevent his aging. Regardless of the exact specifics though, it was clear as long as he had it he wasn't in danger of dying, which was why it was stolen from him.
* Literature/TheBible mentions the tree of life, along with the tree of knowledge, growing in the Garden of Eden. After eating from the tree of knowledge, humanity was exiled from Eden, lest they 'take also from the tree of life and eat, and live forever'.

[[folder:[=MMORPG=]s]]
* In ''VideoGame/RagnarokOnline'', the Soul Linker job change implies that your character owns several.
--> This Witherless Rose will wither away instead of you...\\
This Immortal Heart will cease to pump blood, instead of yours.\\
This Diamond will turn to dust in place of your mortal body.
[[/folder]]

* In Literature/TheBible mentions the tree of life, along with the tree of knowledge, growing in the Garden of Eden. After eating from the tree of knowledge, humanity was exiled from Eden, lest they 'take also from the tree of life and eat, and live forever'.

* In UsefulNotes/{{Christianity}}, the Bible mentions of the tree of life, along with the tree of knowledge. After eating from the tree of knowledge, humanity was exiled, lest they 'take also from the tree of life and eat, and live forever'.