History MadScientist / AnimeAndManga

* In ''Anime/KirbyRightBackAtYa'', one of the many [[MonsterOfTheWeek Monsters of the Week]] is a crazy scientist named Dr. Moro, inspired by TheIslandOfDrMoreau (no kidding) who messes with the DNA of Kirby, his friends, the Cappies, and of course, [[ThoseTwoBadGuys King Dedede and Escargoon]], and uses them to create dinosaur monsters that chase after them all throughout Dedede's theme park. His most powerful dinosaur monster was created from Kirby's superior Star Warrior DNA, and he turns really freaky when he's ordering his minions to attack. And to top it off, he has the typical EvilLaugh of any other Mad Scientist.

* In ''Anime/KirbyRightBackAtYa, one of the many [[MonsterOfTheWeek Monsters of the Week]] is a crazy scientist named Dr. Moro, inspired by TheIslandOfDrMoreau (no kidding) who messes with the DNA of Kirby, his friends, the Cappies, and of course, [[ThoseTwoBadGuys King Dedede and Escargoon]], and uses them to create dinosaur monsters that chase after them all throughout Dedede's theme park. His most powerful dinosaur monster was created from Kirby's superior Star Warrior DNA, and he turns really freaky when he's ordering his minions to attack. And to top it off, he has the typical EvilLaugh of any other Mad Scientist.

* Another one is Grace O'Connor from ''Anime/MacrossFrontier''. Though she doesn't heavily advertise that she ''is'' a scientist in the first place, in fact [[EvilutionaryBiologist she is]], and not the worst one. Given that she's also a HotScientist, and what a [[TheChessmaster scheming]], [[ForScience amoral]], and utterly badass [[MagnificentBastard Magnificent Bitch]] she comes in the end, it's simply unfair to leave her out.

** But played terribly straight with his boss, [[spoiler:Miyo Takano]], who was perfectly willing to [[spoiler:kill the reported host of a HatePlague to make a village suffer the said plague]] ''just to prove that her grandfather wasn't mad''.

* [[PuellaMagiMadokaMagica Kyubey]] in [[PuellaMagiMadokaMagicaTheMovieRebellion the Rebellion movie]] created something called an "Isolation Field", [[spoiler: an energy field that effectively [[SufficientlyAdvancedAliens blocked out the entire Universe,]] powerful enough to pull the [[BigGood Law]] [[CosmicEntity of]] [[AbstractApotheosis Cycles]] into itself. His plan was to see if he could interfere with the Law, because "if (he) could interfere with it, (he) could manipulate it, and if (he) could manipulate it, (he) could control it". His end goal was to "conquer" the Law of Cycles so [[MagicalGirl Magical Girls]] would [[DespairEventHorizon turn]] into [[EldritchAbomination Witches,]] creating vast amounts of energy for [[StarfishAliens his]] [[AliensAreBastards race]] to use.]]

* Bondrewd The Novel from ''Manga/MadeInAbyss'', with more focus on "[[ForScience Scientist]]" and less on "Mad". More like "[[BlueAndOrangeMorality completely alien]]". He has no qualms about taking orphan children to the abyss and experimenting on them, be it [[spoiler:sending them straight to the sixth layer and [[BodyHorror pulling them up]], or [[HumanResources cutting and stripping away all the "unnecessary parts" like the skin, limbs, skeletal system, eyes and such]] to ward off the curse. He even [[GuineaPigFamily experimented on his own daughter]].]] It is implied that he can and does feel love, and honestly treats the kids as his own children. [[BlueAndOrangeMorality He just doesn't see why]] "love" and "his own children" would have anything to do with [[ForScience NOT putting them]] [[TheUnfettered under horrendous experimentation and processing]].

* Bondrewd The Novel from ''Manga/MadeInAbyss'', with more focus on "[[ForScience Scientist]]" and less on "Mad". More like "[[BlueAndOrangeMorality completely alien]]". He has no qualms about [[spoiler:taking orphan children to the abyss and experimenting on them, be it sending them straight to the sixth layer and [[BodyHorror pulling them up]], or [[HumanResources cutting and stripping away all the "unnecessary parts" like the skin, limbs, skeletal system, eyes and such]] to ward off the curse. He even [[GuineaPigFamily experimented on his own daughter]].]] It is implied that he can and does feel love, and honestly treats the kids as his own children. [[BlueAndOrangeMorality He just doesn't see why]] "love" and "his own children" would have anything to do with [[ForScience NOT putting them]] [[TheUnfettered under horrendous experimentation and processing]].

** Kihara Gensei is the head of the entire clan. Just some of of the things we know about him is that [[spoiler: he tricked Mikoto into giving him her DNA map, which set off a series of experiments that resulted in mass-producing clones of her in an attempt to increase the amount of Level 5's. When that proved ineffective, he set off the Sisters project, subjecting all the existing clones to death so that Accelerator can LevelGrind to Level 6. When that gets botched by Touma, he later hijacks the same Misaka Network and forces Mikoto to evolve towards Level 6,knowing fully well that the entire city could be obliterated and that she would lose all control and self-destruct as soon as she reached that point. Yes..this man wanted the entire city to burn just to see what happens.]]

** New Testament volume 7 gives us Yakumi Hisako, one of Academy City's Board of Directors. [[spoiler: She started the Agitate Halation project to get rid of all aspiring heroes in the city by disrupting their AIM fields and forcing them all to have the desire to protect Fremea Seivelun, causing massive chaos. In the process, she gets eaten by her own man-eating roaches, but this all turned out to be a front, as her true objective from the entire chaos was to become an AIM being and access the realm where Hyouka and Aiwass were able to reside once Fremea was killed. Even if she knew her consciousness would disperse within seconds of what she would witness. ''ForScience!'' indeed.]]

* [[spoiler: [[PuellaMagiMadokaMagica Kyubey]] in [[PuellaMagiMadokaMagicaTheMovieRebellion the Rebellion movie]] created something called an "Isolation Field", an energy field that effectively [[SufficientlyAdvancedAliens blocked out the entire Universe,]] powerful enough to pull the [[BigGood Law]] [[CosmicEntity of]] [[AbstractApotheosis Cycles]] into itself. His plan was to see if he could interfere with the Law, because "if (he) could interfere with it, (he) could manipulate it, and if (he) could manipulate it, (he) could control it". His end goal was to "conquer" the Law of Cycles so [[MagicalGirl Magical Girls]] would [[DespairEventHorizon turn]] into [[EldritchAbomination Witches,]] creating vast amounts of energy for [[StarfishAliens his]] [[AliensAreBastards race]] to use.]]

* Inverted with Irie, from ''VisualNovel/HigurashiWhenTheyCry''. While he did [[spoiler:do vivisections on people]], and does act a bit "[[{{Lolicon}} odd"]] toward Satoko, he's an honestly nice, smart father figure.

** There's Shou Tucker, who, under the pretense of having to produce good results in order to keep his license as a State Alchemist (although he later admits it was mostly [[ForTheEvulz "just to see if I could do it"]], [[spoiler: combines his own young daughter, Nina, and her pet dog into a chimaera, condemning them to a FateWorseThanDeath from which Scar is forced to release them via MercyKill.]] He doesn't fit the traditional profile of this trope (he appears quite calm and kind for most of the time we see him), but there is no doubt that he crossed the MoralEventHorizon on that one.

* ''Manga/{{Naruto}}'':
** Some of the villains get into this, most notably [[SmugSnake Orochimaru]] and his MadDoctor BastardUnderstudy, [[TheMole Kabuto]].
** Madara is getting into this too, what with him collecting eyes, Zetsu army, and cloning Hashirama. Though you could argue he's not really a "mad" scientist so much as an ArrogantKungFuGuy scientist.

* Another one is Grace O'Connor from ''Anime/MacrossFrontier''. Though she doesn't heavily advertise that she ''is'' a scientist in the first place, in fact [[EvilutionaryBiologist she is]], and not the worst one. Given that she's also a HotScientist, and what a [[TheChessmaster scheming]], [[ForScience amoral]], and utterly {{badass}} [[MagnificentBastard Magnificent Bitch]] she comes in the end, it's simply unfair to leave her out.

* Some of the ''Manga/{{Naruto}}'' villains get into this, most notably [[SmugSnake Orochimaru]] and his MadDoctor BastardUnderstudy, [[TheMole Kabuto]].
** Madara is getting into this too, what with him collecting eyes, Zetsu army, and cloning Hashirama. Though you could argue he's not really a "mad" scientist so much as a douchebag scientist.

* Dantalion the [[BossSubtitles Seeking Researcher]] from ''LightNovel/ShakuganNoShana''. He is [[LargeHam outrageously excitable]] and creates his mad experiments ForScience, and not necessarily for evil means. One suspects that if he weren't contracted to the bad guys he'd be mostly harmless. He looks exactly like Father Anderson from ''Hellsing''.
* Speaking of ''{{Hellsing}}'', there is The Doktor, chief scientist of the [[StupidJetpackHitler Millennium Group]].

* The Elder in ''ChronoCrusade'' is a mild example of this trope. He's not ''completely'' insane, but his inventions tend to be quirky at best and downright dangerous at worst. Some of the things he's responsible for in the series include purposefully allowing [[HotBlooded Rosette]] to steal an experimental bullet with a demon trapped inside so he wouldn't have to test it himself, and apparently fusing a friend with demonic legion in order to make him a better fighter. Oh, and he's a DirtyOldMan to top it all off.

* Matthew Denton of ''{{Heroman}}'', no question. He's the good version-also no question, because in the 2nd episode he gives many InTheNameOfTheMoon speeches about how [[TheAtoner the alien invasion is his fault and thus he must stop it]]. Most of the stuff he comes up with could not have been conceived by a completely sane mind, ([[RuleOfCool This is Anime]]) the most notable being a weaponized guitar that can kill cockroach aliens.

* ''WeissKreuz'' is almost as fond of these as it is of {{Mad Artist}}s - see particularly Takatori Masafumi, and Tsuji Mayumi in ''Weiss Kreuz: Glühen''.

* ''[[{{Gunnm}} Battle Angel Alita]]'': Desty Nova. Mad laugh, human experiments, cloning, nanomachines, lack of morals, the whole works, and he's ''proud'' of it.

* Okabe Rintaro (or [[LargeHam HOUOIN KYOUMA!]] as he sometimes prefers to be called) of ''SteinsGate'' is a self-proclaimed example, often prone to peals of EvilLaughter, bouts of paranoia, and referring to his inner circle of friends as lab members. Yet despite all of this, he can be surprisingly grounded at times, and realizes that he and his friends' dabbling in time travel and poking about a GovernmentConspiracy could land them in very hot water.
* Rinichiro Hagire, from ''DeadmanWonderland''. He found a way to overwrite people's memories with his own, so that his conscious could continue to live through another's body, completely under his control. He also started a macabre carnaval in his search for the strongest Deadman for his next "generation." Death was expected by the loser. At the time of the [[spoiler: the Wretched Egg's birth, he was testing human immunity, searching for a way to improve it, and eventually created the Deadman]], he is now [[spoiler:trying to turn of the MGS so that Shiro can be at FULL POWER which caused a huge earthquake when she first awoke, submerging the entire city of Tokyo]].
* Doc from ''{{Texhnolyze}}'', who doubles as a HotScientist. Putting aside her prosthetic limb fetish and her tendency to have sex with her patients, she also puts wheels on a rat for no reason other than her own apparent amusement.
* Dr. Hogback from ''OnePiece'', who builds zombies for his master Gekko Moriah, and has no respect for life despite being a doctor.

** [[BigBad Dr. Jail Scaglietti]] of ''Anime/MagicalGirlLyricalNanohaStrikerS''. In fairness, it turns out that [[spoiler:he's an ArtificialHuman who was specifically created to be that way]]. Unlike most of the {{Gadgeteer Genius}}es here, actually refers to himself as an engineer. He also seems to be incapable of feeling anger and never falls in a VillainousBreakdown.
** [[SpellMyNameWithAnS Presea]] [[BigBad Testarossa]] from the [[Anime/MagicalGirlLyricalNanoha first season]], who snapped over the [[spoiler:loss of her daughter Alicia, spending centuries to find a way to revive her]].

* While Shiho Miyano of ''Manga/DetectiveConan'' may not qualify as a Mad Scientist, since she was forced into doing her research, her father certainly does. The series specifically mentions that her father was considered a mad scientist even by the standards of the Black Organization. That's pretty mad.

* Dr. Akihiro Kanou from ''Manga/TokyoGhoul''. [[spoiler: When confronted about ''intentionally'' turning Kaneki into a HalfHumanHybrid, he makes a speech about being AboveGoodAndEvil. His experiments have left dozens of innocent people either mutated into mentally disabled freaks of nature or dead, with only ''four'' known successes]]. In response, Kaneki calls him a [[PrecisionFStrike fucking]] lunatic.

* ''HajimeteNoAku''. The protagonist Jiro is a self-proclaimed Mad Scientist, Although in fact he seems to be incapable of doing anything evil.

* Dr. Franken von Vogler from the ''GiantRobo'' OVA was introduced as a classic ranting Mad Scientist. [[spoiler:The series subverts this trope, as successive flashbacks reveal more about his real motivations.]]
* Icchan from ''KidouTenshiAngelicLayer'' is often mistaken for a Mad Scientist; he seems to encourage it, making over-the-top dramatic entrances, speaking cryptically about his creations whenever he can, and wearing his lab coat all the time.

%%* Doctor Gero of ''DragonballZ''

* Yoshizumi-sensei of ''ZombieLoan''. He started off as a reasonably sane college scientist, but when [[spoiler:Caramelo]] of the ARRC turned him into a zombie, he [[GoMadFromTheRevelation snapped]]. He ends up [[spoiler:merging with his "masterwork", the Phalanx, only to be killed by Sawatari.]]

* Hiroshi from ''MyDearMarie'' builds himself a RobotGirl [[ReplacementGoldfish who both looks identical and has the same name to a woman he has a crush on]]. When the two meet by chance, he tells everyone that they're [[LikeBrotherAndSister siblings]] as a cover story.

* Dr. Kaff from the Korean version of ''MazingerZ'', ''[[Animation/RobotTaekwonV Robot Taekwon V]]'' is a thoroughly ridiculous example of this, and a LargeHam who wants to TakeOverTheWorld.

* Inverted with Irie, from ''VisualNovel/HigurashiNoNakuKoroNi''. While he did [[spoiler:do vivisections on people]], and does act a bit "[[{{Lolicon}} odd"]] toward Satoko, he's an honestly nice, smart father figure.

* ''LoveHina'': Kaolla Suu is CrazyAwesome in that she's always gotta build bigger and better mechas based on the flying turtle, Tama-chan. These also explode on a regular basis. She even [[LampshadeHanging lampshades]] it in one episode by saying that having your creations explode spectacularly just seems like something a Mad Scientist would do.
** Kaolla Suu's name follows the "Western" order; that is, her surname (or family name) is Suu, and her given name is Kaolla.

* Another one is Grace O'Connor from ''MacrossFrontier''. Though she doesn't heavily advertise that she ''is'' a scientist in the first place, in fact [[EvilutionaryBiologist she is]], and not the worst one. Given that she's also a HotScientist, and what a [[TheChessmaster scheming]], [[ForScience amoral]], and utterly {{badass}} [[MagnificentBastard Magnificent Bitch]] she comes in the end, it's simply unfair to leave her out.
* ''{{Sekirei}}'' has a few, but the biggest, craziest, and downright [[LargeHam hammiest]] of them all is Hiroto Minaka, MBI's [[CorruptCorporateExecutive psychotic and manipulative CEO.]] He's hinted to be behind the discovery of the original Sekirei and the making of the current ones, and is CONFIRMED to be [[ChessMaster manipulating every single person in the series towards his own bizarre ends]] and [[JerkAss making every character hate him in the process]], but earning [[DracoInLeatherPants massive fan love]] for his ImpossiblyCoolClothes and general {{Crazy Awesome}}ness.

* One story in ''TheKindaichiCaseFiles'' features the story of a mad scientist who, during WWII, chopped up soldiers and tried to sew the pieces into the ultimate human. [[spoiler:It turns out that the ''real'' "mad scientist" was a pharmaceutical company that tested experimental drugs on six patients, all of whom died.]]