Line #63 MadScientist/AnimeAndManga


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7	{{Mad Scientist}}s in AnimeAndManga.
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9	* ''Manga/The100GirlfriendsWhoReallyReallyReallyReallyReallyLoveYou'': Girlfriend #5 is Kusuri Yakusen, the third year head of the school chemistry club. She specializes in making drugs with unworldly effects, one of which gave her the appearance of an 8-year-old girl which can only be reverted for a short period at a time. She's also tested other drugs on herself.
10	* Hange Zoe of ''Manga/AttackOnTitan'' is a heroic example, being the [[CloudCuckooLander eccentric]] head of Titan research for the Survey Corps. Hange has some aspirations towards being a FluffyTamer, but is also responsible for a good percentage of what humanity knows about Titans. Traps, zany experiments involving [[spoiler: Eren performing tasks in Titan form]], and generally terrifying bystanders is business as usual.
11	* ''Literature/{{Baccano}}'' has Szilard Quates, Huey Laforet, and Renée Brinvillier. All three are immortal alchemists, and also happen to have [[MadScientistsBeautifulDaughter the requisite beautiful daughter]] (with the latter two sharing theirs).
12	* ''Anime/BagiTheMonsterOfMightyNature'': The one responsible for [[spoiler:the creation of Bagi]]. A mild example though, since he is not ''that'' mad.
13	* ''Manga/BattleAngelAlita'': Desty Nova. Mad laugh, human experiments, cloning, nanomachines, lack of morals, the whole works, and he's ''proud'' of it.
14	* Sally from ''Manga/BlackClover'' really wants to dissect and experiment on Asta, expressing her desire with an almost child-like glee. She joined the Eye of the Midnight Sun because they'd let her perform experiments that the Magic Knights wouldn't.
15	* ''Manga/{{Bleach}}'':
16	** [[TokenEvilTeammate Mayuri Kurotsuchi]] is an extreme example, a combination of MadScientist, MadDoctor and AxCrazy to boot, openly boasting of the thousands of souls he's experimented on in his studies. Yet he leads one of the Soul Society's 13 squads (his contains lots of [[QuirkyMinibossSquad quirky]] [[TheIgor assistants]]) and is a valued member. You begin to see the problem that the rest of Soul Society has with the administration.
17	** His Arrancar equivalent is [[EvilutionaryBiologist Szayelaporro Granz]], who shares his twisted science, represented the aspect of death known as "madness" and whose own QuirkyMinibossSquad existed solely to provide him with food whenever he needed to heal injuries. In the battle between Szayel and Mayuri, the fight ended up boiling down to which scientist was the most insane and the most capable of using that insanity in disturbingly creative ways. The winner, by a large margin, was Mayuri.
18	** [[BrokenAce Sosuke Aizen]] is one as well. His madness is quieter than Mayuri, harder to see until he's unmasked as the villain early in the story. As the story develops, his madness becomes more and more noticeable as the stakes get higher and higher. His shinigami/hollow/human/[[spoiler:quincy]] experiments, however, have never been the experiments of someone with a sound mind, what with the constant killing ForScience and his [[GodhoodSeeker "I will become God!"]] obsession.
19	*** Somewhat unusually for a Mad Scientist, Aizen ''likes'' when his experiments don't produce what he wanted them to, finding it more interesting when something unexpected happens.
20	* While Shiho Miyano of ''Manga/CaseClosed'' may not qualify as a Mad Scientist, since she was forced into doing her research, her father Atsushi certainly does. The series specifically mentions that her father was considered a mad scientist even by the standards of the Black Organization. That's pretty mad. [[spoiler: Though Agasa says that Atsushi wasn't ''that'' crazy, but actually a rather decent guy. Since he is Shiho-aka-Ai's ParentalSubstitute, lying about this would be just too risky...]]
21	* With ''Literature/ACertainMagicalIndex'' being staged in a city technologically ahead of the rest of the world by 30 years, it's no surprise there would be mad scientists. One of the most prominent is an entire clan of mad scientists called the Kiharas, and it's strongly implied in the series that all the experiments they get involved in are solely ''ForScience!'' regardless of implications. To mention just a few:
22	** Kihara Amata raised and influenced Accelerator from a young age, and even trained him in his vector manipulation abilities. As a result, when Accelerator has to confront him later, [[spoiler: Amata perfected his combat so precisely he can reverse the force of his fists once they reach Accelerator's reflection, forcing them past his barrier and hitting him. And Amata isn't even an esper.]]
23	** Kihara Gensei is the head of the entire clan. Just some of of the things we know about him is that [[spoiler: he tricked Mikoto into giving him her DNA map, which set off a series of experiments that resulted in mass-producing clones of her in an attempt to increase the amount of Level 5's. When that proved ineffective, he set off the Sisters project -- having Accelerator slaughter the clones in order to reach Level 6. When that gets botched by Touma, he later hijacks the clone Network and forces Mikoto to evolve towards Level 6, knowing fully well that she would self-destruct and destroy all of Academy City if she reached that point. Yes... this man wanted the entire city to burn just to see what would happen.]]
24	** It is mentioned that the reason Academy City maintains a tight leash over the espers and technology is partly an effort to keep all the Kiharas in one place where technology was at its finest. [[spoiler:Otherwise they would spread chaos on a global scale.]]
25	** New Testament Volume 7 gives us a non-Kihara example in Yakumi Hisako, one of Academy City's Board of Directors. [[spoiler: She starts the Agitate Halation project to get rid of all aspiring heroes in the city by tricking them into killing each other. In the process, she gets eaten by her own man-eating roaches, but this all turned out to be a front, as her true objective from the entire chaos was [[AscendedToAHigherPlaneOfExistence to become an AIM being]]. Even if she knew her consciousness would disperse within seconds of what she would witness]]. ''ForScience!'' indeed.
26	* The Elder in ''Manga/ChronoCrusade'' is a mild example of this trope. He's not ''completely'' insane, but his inventions tend to be quirky at best and downright dangerous at worst. Some of the things he's responsible for in the series include purposefully allowing [[HotBlooded Rosette]] to steal an experimental bullet with a demon trapped inside so he wouldn't have to test it himself, and apparently fusing a friend with demonic legion in order to make him a better fighter. Oh, and he's a DirtyOldMan to top it all off.
27	* ''Anime/CodeGeass'':
28	** Nina Einstein, a Teenage Mad Scientist Girl. She is particularly known for being a PsychoLesbian and inventing weapons of mass destruction. And there's the table incident.
29	** [[BunnyEarsLawyer Earl Lloyd Asplund]] is an older, slightly more comedic version of the trope.
30	*** Lloyd plays with the trope as while he is eccentric and disrespectful, he is fully aware that he is a mad scientist. Also, he is the only (non-royal) noble in the series to have no lust for power and not be racist, and in that respect is in some ways the OnlySaneMan.
31	*** However, Lloyd plays it straighter in the AlternateUniverse manga ''Suzaku of the Counterattack'', where he willingly goes along with Prince Schneizel's plan to gain C.C.'s powers in order to TakeOverTheWorld, even though it could potentially destroy the Earth (and almost does, if not for the intervention of the heroes).
32	* Dr. Schroeder from ''Anime/DarkerThanBlack'' is a nice old man, but, as a [[http://www.epicwin.org/2007/10/01/darker-than-black-24/ review]] put it, "just when you start thinking he's fairly normal, he goes on a slightly psycho, childish rampage".. He only wants to rid the Earth of the AlienSky that shut all space programs down. The side effect he ''expects'' would be [[spoiler:killing as many people as there are stars in the sky]]. A problem not explored in series is that there's [[NoPlansNoPrototypeNoBackup no way to test]] his project and ensure that in process the whole Earth will not suffer the same fate as all those vanished rockets, turn into one big [[RealityIsOutToLunch Gate]], etc. ''He'' is quite sure his theory will work out ''exactly'' as he expects, so WhatCouldPossiblyGoWrong?
33	** Dr. Etou from the ''Shikkoku no Hana'' manga, on the other hand, is a [[SlasherSmile grinning]], stuttering and almost drooling specimen -- when his superior [[DopeSlap snaps him out of rants by punching]] this doesn't even look like needless cruelty.
34	* Seed Eight in ''Manga/TheDarkQueenAndIStrikeBack'' is the director of the humans' Engineering Bureau and the main reason for their advanced technology. His work includes experimentation on people, and he has no problems with disposing of anyone who doesn't meet his standards.
35	* Rinichiro Hagire, [[spoiler:the true BigBad]] from ''Manga/DeadmanWonderland''. He found a way to overwrite people's memories with his own, so that [[spoiler:his consciousness could continue to live through another's body, completely under his control]]. He also started a macabre carnival in his search for the strongest Deadman for his next "generation." Death was expected by the loser. At the time of [[spoiler:the Wretched Egg's birth]], he was [[spoiler:testing human immunity, searching for a way to improve it, and eventually created the Deadman]]; he is now [[spoiler:trying to turn of the MGS so that the Egg/Shiro can be at FULL POWER, which caused a huge earthquake when she first awoke, submerging the entire city of Tokyo]].
36	* ''Anime/DragonBallZ'''s Dr. Gero built a series of androids, and then turned himself into a cyborg, in order to exact revenge on Goku, who destroyed the Red Ribbon Army decades ago.
37	* Izaya Orihara of ''Literature/{{Durarara}}'' is what happens when a mad scientist tries his hand at sociology. Note that this ends up being impossible to distinguish from a {{troll}}.
38	* [[Manga/FrankenFran Fran Madaraki]]. She's also a MadScientistsBeautifulDaughter (if you don't mind the stitches), who [[BodyHorror completely lacks]] any understanding [[NightmareFuelStationAttendant of the word]] squick. And she does half of it ForScience, and the other half to save lives... no matter the cost to quality of life. Her "[[TrulySingleParent father]]" is even moreso.
39	* ''Manga/FullmetalAlchemist'', instead of dealing with the Mad Scientist, revives its predecessor-trope, the almost forgotten Mad Alchemist (see below).
40	** There's Shou Tucker, who, under the pretense of having to produce good results in order to keep his license as a State Alchemist (although he later admits it was mostly [[ForScience "just to see if I could do it"]]) [[spoiler: combines his own young daughter, Nina, and her pet dog into a chimaera, condemning them to a FateWorseThanDeath from which Scar is forced to release them via MercyKill.]] He doesn't fit the traditional profile of this trope (he appears quite calm and kind for most of the time we see him), but there is no doubt that he crossed the MoralEventHorizon on that one.
41	** ''Anime/FullmetalAlchemistTheConquerorOfShamballa'' introduces a scientist who is severely ticked at the world's alchemists for making his work worthless. The "mad" part of this shows up when he reveals that he discovered Uranium and threatens the Elrics with a ''hand-held nuke''. Clearly he never tested the thing.
42	* ''Manga/GetterRobo'' has a few. Saotome is the most famous example, though he's very low-key (except in the ''Armageddon'' OVA) about it and fairly normal on the surface. Professor Shikashima on the other hand has several screws loose (and indeed, actually ''has one lodged in his skull'') but his craziness is mostly played for laughs. In ''Manga/GetterRobo''? [[spoiler:Hayato replaces Saotome as the leading scientist, with his trademark AxCrazy streak]].
43	* Dr. Franken von Vogler from the ''Anime/GiantRobo'' OVA was introduced as a classic ranting Mad Scientist. [[spoiler:The series subverts this trope, as successive flashbacks reveal more about his real motivations.]]
44	* ''Literature/TheGreatestMagicmastersRetirementPlan'': Godma Barhong is the researcher in charge of Alpha's Element Factor Separation Project. In his experiments to turn test subjects into light magic users, he broke their minds and left most of them as [[FateWorseThanDeath mindless slaves to his will]]. When Alpha's government decided to shut down his research, he went into hiding to continue his experiments, kidnap more test subjects, and kill anyone who tries to stop him.
45	* ''Manga/HajimeteNoAku''. The protagonist Jiro is a self-proclaimed Mad Scientist, Although in fact he seems to be incapable of doing anything evil.
46	* ''Manga/HanaukyoMaidTeam''. Head maid of the Technology Department Ikuyo Suzuki sometimes becomes a mad scientist. When she does so, her spectacles become ScaryShinyGlasses. In ''La Verite'', her face usually gets distorted as well.
47	* ''Manga/HayateTheCombatButler'': Makimura Shiori seems to think that nursing robots need lots of missiles and rocket boosters. Unfortunately, most of her inventions either blow up or go berserk. In one episode, her boss asks her why all of her projects are complete failures. Her answer? [[StuffBlowingUp "Um, not enough firepower?"]]
48	* Speaking of ''Manga/{{Hellsing}}'', there is The Doktor, chief scientist of the [[StupidJetpackHitler Millennium Group]].
49	* Matthew Denton of ''Manga/{{Heroman}}'', no question. He's the good version-also no question, because in the second episode he gives many InTheNameOfTheMoon speeches about how [[TheAtoner the alien invasion is his fault and thus he must stop it]]. Most of the stuff he comes up with could not have been conceived by a completely sane mind, ([[RuleOfCool This is Anime]]) the most notable being a weaponized guitar that can kill cockroach aliens.
50	* Inverted with Irie, from ''VisualNovel/HigurashiWhenTheyCry''. While he did [[spoiler:do vivisections on people]], and does act a bit "odd" toward Satoko, he's an honestly nice, smart father figure.
51	** But played terribly straight with [[spoiler:his boss, Miyo Takano]], who was perfectly willing to [[spoiler:kill the reported host of a HatePlague to make a village suffer the said plague]] ''just to [[spoiler:prove that her grandfather wasn't mad]]''.
52	* ''Manga/HollowFields'' is a manga about a school for mad scientists' children. The children get a classic education in things like making SteamPunk killer robots, making hideous animal hybrids, poisonmaking, and many, many other subjects.
53	* One of the villains in ''Anime/HugttoPrettyCure'', Dr. Traum, is one of these. He doesn't seem to be entirely mad, but he is one of the villains, so he definitely qualifies. Most of his science seems to be related to robots- fittingly, [[spoiler:it is later revealed that was the one who made RobotGirl Ruru, who had undergone a HeelFaceTurn at the time of his debut.]]
54	* Icchan from ''Manga/AngelicLayer'' is often mistaken for a Mad Scientist; he seems to encourage it, making over-the-top dramatic entrances, speaking cryptically about his creations whenever he can, and wearing his lab coat all the time.
55	** However, his invention makes sense, is based on diligent research, operates on the notion that the principles discovered in previous discoveries can lead to new ones, is dependent on capitalism to provide funds and is profitable for mankind in general. Mad Scientists everywhere are very, very disappointed in him.
56	* One story in ''Manga/TheKindaichiCaseFiles'' features the story of a mad scientist who, during WWII, chopped up soldiers and tried to sew the pieces into the ultimate human. [[spoiler:It turns out that the ''real'' "mad scientist" was a pharmaceutical company that tested experimental drugs on six patients, all of whom died.]]
57	* In ''Anime/KirbyRightBackAtYa'', one of the many [[MonsterOfTheWeek Monsters of the Week]] is a crazy scientist named Dr. Moro, inspired by ''Literature/TheIslandOfDoctorMoreau'' (no kidding) who messes with the DNA of Kirby, his friends, the Cappies, and of course, King Dedede and Escargoon, and uses them to create dinosaur monsters that chase after them all throughout Dedede's theme park. His most powerful dinosaur monster was created from Kirby's superior Star Warrior DNA, and he turns really freaky when he's ordering his minions to attack. And to top it off, he has the typical EvilLaugh of any other Mad Scientist.
58	* ''Anime/KnightHunters'' is almost as fond of these as it is of {{Mad Artist}}s -- see particularly Takatori Masafumi, and Tsuji Mayumi in ''Weiß Kreuz: Glühen''.
59	* Sucy Manbavaran from ''Franchise/LittleWitchAcademia'' is the witching world's equivalent of a mad scientist. She loves coming up with new potions and poisons, then testing them out on unsuspecting victims. [[WithFriendsLikeThese Mostly her friends]]. Sucy's EstablishingCharacterMoment is her trapping Akko and Lotte in a net as bait for a cockatrice so that Sucy can steal one of its feathers as an ingredient for her newest potion.
60	* ''Manga/LoveHina'': Kaolla Suu is awesome in that she's always gotta build bigger and better mechas based on the flying turtle, Tama-chan. These also explode on a regular basis. She even {{lampshade\|Hanging}}s it in one episode by saying that having your creations explode spectacularly just seems like something a Mad Scientist would do.
61	* ''Franchise/LyricalNanoha'':
62	** [[BigBad Dr. Jail Scaglietti]] of ''Anime/MagicalGirlLyricalNanohaStrikers''. In fairness, it turns out that [[spoiler:he's an ArtificialHuman who was specifically created to be that way]]. Unlike most of the {{Gadgeteer Genius}}es here, actually refers to himself as an engineer. He also seems to be incapable of feeling anger and never falls in a VillainousBreakdown.
63	** [[BigBad Presea Testarossa]] from the [[Anime/MagicalGirlLyricalNanoha first season]], who snapped over the [[spoiler:loss of her daughter Alicia, spending decades to find a way to revive her]].
64	* [[spoiler:[[ManBehindTheMan Grace O'Connor]]]] from ''Anime/MacrossFrontier''. Though they don’t heavily advertise that they ''are'' a scientist in the first place, in fact [[EvilutionaryBiologist they are]], and not the worst one, even considering [[spoiler:what a [[TheChessmaster scheming]], [[ForScience amoral]], and utterly badass [[MagnificentBastard Magnificent Bitch]] she becomes in the end]].
65	* Bondrewd The Novel from ''Manga/MadeInAbyss'', with more focus on "[[ForScience Scientist]]" and less on "Mad". More like "[[BlueAndOrangeMorality completely alien]]". He has no qualms about taking orphan children to the Abyss and experimenting on them, be it [[spoiler:sending them straight to the Sixth Layer of the Abyss and [[BodyHorror pulling them up]], or [[HumanResources cutting and stripping away all the "unnecessary parts" like the skin, limbs, skeletal system, eyes and such]] to ward off the curse. He even [[GuineaPigFamily experimented on his own daughter]].]] It is implied that he can and does feel love, and honestly treats the kids as his own children. [[BlueAndOrangeMorality He just doesn't see why]] "love" and "his own children" would have anything to do with [[ForScience NOT putting them]] [[TheUnfettered under horrendous experimentation and processing]].
66	* [[spoiler: Ivan Alexandr]] in ''Manga/{{Marginal}}''. He is obsessed with the womb and runs away to [[spoiler:Earth]] so that he can freely experiment with creating [[ArtificialHuman hermaphrodites]].
67	* Dr. Hell from ''Anime/MazingerZ''. In some versions (including the original manga), Juzo Kabuto is a mix of this and TheProfessor. And he has a handsome and HotBlooded grandson named Koji Kabuto, the main character.
68	* ''Anime/MobileSuitGundam'' has a rather tragic example with Tem Ray, Amuro's father. Originally he was a decent man (if very distant to his son), but when their home colony is attacked he gets pulled into space and suffers brain damage due to oxygen deprivation. The next time Amuro sees him, he's in a basement cobbling gobbling electronics into "upgrades" for the Gundam and rambling to himself.
69	* Ginias Sakhalin from ''Anime/MobileSuitGundamThe08thMSTeam'', the head of the Apsalus Project, which could be best described as a miniature [[Franchise/StarWars Death Star]] that kills cities instead of planets. He starts out relatively sane if overly dedicated, but he deteriorates as time goes on.
70	** He also has the [[MadScientistsBeautifulDaughter Mad Scientist's Beautiful Sister]]. Who is the [[DatingCatwoman hero's girlfriend]].
71	** Granted his looks are a bit more... [[{{Bishonen}} delicate and effeminate]] than this trope usually entails. As in, he looks more like a stereotypical hairdresser than mad scientist.
72	* Adam from ''Manga/MotherKeeper'' is stated to be this by Jim and Zelik. It's yet to be revealed how he earned this title but he did turn a blood-loving terrorist into a superpowered immortal cyborg.
73	* Hiroshi from ''Manga/MyDearMarie'' builds himself a RobotGirl [[ReplacementGoldfish who both looks identical and has the same name to a woman he has a crush on]]. When the two meet by chance, he tells everyone that they're [[LikeBrotherAndSister siblings]] as a cover story.
74	* ''Manga/{{Naruto}}'': Some of the villains get into this, most notably [[SmugSnake Orochimaru]], who created the Cursed Seals from Juugo as well a BodySurf Jutsu in order to master all the jutsus in the world ,and his MadDoctor BastardUnderstudy, [[TheMole Kabuto]], [[spoiler:who perfected the Edo Tensei Kinjutsu]].
75	* Satomi Hakase and Chao Lingshen from ''Manga/NegimaMagisterNegiMagi'', refer to themselves as having sold their souls to science.
76	* At least a third of the major characters in ''Anime/NeonGenesisEvangelion'' are mad, or at least amoral, scientists.
77	* ''Manga/OnePiece'':
78	** Dr. Hogback, who builds zombies for his master Gekko Moriah, and has no respect for life despite being a doctor.
79	** From the Punk Hazard arc, we have Caesar Clown, who's an even bigger asshole, and even more nuts. [[spoiler:He kidnapped and experienced on children, and used a very dangerous drug on them to keep them from escaping, he has absolutely zero respect for anyone, his forte is [[WeaponOfMassDestruction weapons of mass destruction]], he acts like a nice guy to his underlings only to perform more experiments on them later, he caused an incident that made Punk Hazard into a wasteland, then collected the leftover poisonous gas from that incident to make a BlobMonster, which he later changed ''back'' into an even deadlier gas that petrifies its victims]]... What makes it even worse is that [[spoiler:a [[TheMole mole]] in the Marines covers up all of his actions, allowing him to do as he pleases]].
80	* ''Anime/PokemonTheSeries'' loves this trope, especially for villains:
81	** Dr. Fuji, the ReluctantMadScientist who created Mewtwo for Giovanni [[spoiler:in hopes he'd be able to revive his dead daughter]].
82	** Professor Sebastian, who likes [[GadgeteerGenius messing with radio waves]] to lure Pokémon/force them to evolve.
83	** Dr. Namba, the campiest mad scientist on the list, who builds frequently ridiculous contraptions to capture Pokémon for Team Rocket, particularly Cassidy and Butch. [[BerserkButton Don't get his name wrong, whatever you do.]]
84	** Dr. Zager, another Team Rocket scientist, who assists Jessie and James in Unova and [[HighClassGlass sports a monocle]].
85	** Dr. Yung, from ''Anime/TheMastermindOfMiragePokemon'', who [[spoiler:is revealed to be the titular "mastermind", attempting to take over the world with super-powerful Pokémon holograms]].
86	** Butler, in ''Anime/PokemonJirachiWishMaker'', [[spoiler:laughed out of Team Magma for a failed attempt to re-create Groudon]], who now travels as a circus magician, [[spoiler:but tries his experiment again using [[PoweredByAForsakenChild Jirachi as a power source]]]] and ends up having it work a little too well.
87	** Zero, the {{yandere}} villain of the eleventh movie, an assistant for an aborted project. After being abandoned by his mentor, obsession drives him to [[ThereIsNoKillLikeOverkill take reviving it a bit too far]]. And by "take it a bit too far" we mean "threatening anyone who stands in his way with poisonous gas or a [[HumongousMecha giant robot"]].
88	** Cyrus, leader of Team Galactic and OmnicidalManiac.
89	** Charon, official scientist of Team Galactic.
90	** [[spoiler:Dr. Zed from ''Anime/PokemonSecretsOfTheJungle'' is one who murdered two people to accomplish his goals]].
91	* ''Anime/PuellaMagiMadokaMagica'' has [[spoiler:[[HiveMind Kyubey]]]], who [[spoiler:created a system that turns girls into {{MagicalGirl}}s and [[TheCorruption slowly corrupts them into]] [[EldritchAbomination witches]]. They let them loose on humanity, not caring who dies, as long as the resulting despair can be used to [[WellIntentionedExtremist save the universe from heat death]]]]. Then in [[Anime/PuellaMagiMadokaMagicaTheMovieRebellion the Rebellion movie]] they [[spoiler:created something called an "Isolation Field", an energy field that effectively [[SufficientlyAdvancedAliens blocked out the entire Universe,]] powerful enough to pull the [[BigGood Law]] [[CosmicEntity of]] [[AbstractApotheosis Cycles]] into itself. Their plan was to see if they could interfere with the Law, because "if (they) could interfere with it, (they) could manipulate it, and if (they) could manipulate it, (they) could control it". Their end goal was to "conquer" the Law of Cycles so [[MagicalGirl Magical Girls]] would [[DespairEventHorizon turn]] into [[EldritchAbomination Witches]] again, creating vast amounts of energy for [[StarfishAliens the]] [[AliensAreBastards species]] to use. [[NotSoWellIntentionedExtremist All for the sake of the universe]], [[{{Hypocrite}} of course]]]].
92	* Professor Souichi Tomoe from ''Franchise/SailorMoon''. In the first [[Anime/SailorMoon anime version]] he was possessed by a demonic being that lived in his eye; in the [[Manga/SailorMoon manga]], he was just plain evil.
93	* ''Manga/{{Sekirei}}'' has a few, but the biggest, craziest, and downright [[LargeHam hammiest]] of them all is Hiroto Minaka, MBI's [[CorruptCorporateExecutive psychotic and manipulative CEO.]] He's hinted to be behind the discovery of the original Sekirei and the making of the current ones, and is CONFIRMED to be [[ChessMaster manipulating every single person in the series towards his own bizarre ends]] and [[JerkAss making every character hate him in the process]], but earning [[DracoInLeatherPants massive fan love]] for his ImpossiblyCoolClothes and general {{Crazy is Cool}}ness.
94	* ''Manga/SgtFrog'': Kululu, who's also an InsufferableGenius, and the WitchDoctor.
95	* Dantalion the [[BossSubtitles Seeking Researcher]] from ''Literature/ShakuganNoShana''. He is [[LargeHam outrageously excitable]] and creates his mad experiments ForScience, and not necessarily for evil means. One suspects that if he weren't contracted to the bad guys he'd be mostly harmless. He looks exactly like Father Anderson from ''Manga/{{Hellsing}}''.
96	* [[HeroicComedicSociopath Professor Franken Stein]] of ''Manga/SoulEater'', whose love of dissection is played for laughs early on. [[spoiler:The "mad" aspect becomes important later on, as madness is [[CosmicHorrorStory somewhat more concrete]] in this world.]] [[MagnificentBastard Medusa]] definitely counts as well. Eibon could count as this as well, in both the anime and manga, because not only does he eradicate the madness of knowledge but he teamed up with Arachnophobia (an evil witch) to invent his magic tools and demon weapons, although it seems as if he has truly benign intentions at heart.
97	** Stein's likening for cutting people up ''is'' played for laughs, but it's also what he seriously would have done to Medusa given the chance (and Spirit, and Maka, and Kid, and anyone he saw as interesting). In the witch's case he settles for dismembering her and shoving a scythe blade into her skull for good measure.
98	* Okabe Rintaro (or [[LargeHam HOUOUIN KYOUMA!]] as he sometimes prefers to be called) of ''VisualNovel/SteinsGate'' is a self-proclaimed example, often prone to peals of EvilLaughter, bouts of paranoia, and referring to his inner circle of friends as lab members. Yet despite all of this, he can be surprisingly grounded at times, and realizes that he and his friends' dabbling in time travel and poking about a GovernmentConspiracy could land them in very hot water.
99	** The sequel, ''VisualNovel/SteinsGate0'', introduces a real one in [[spoiler: Alexis Leskinen]], an evil genius who willing to spark WorldWarIII if it advances his theories, and is willing to commit unethical actions such as human experimentation, brainwashing and torture to get his way.
100	* ''Anime/{{Texhnolyze}}'': Doc. Putting aside her prosthetic limb fetish and her tendency to have sex with her patients, she also puts wheels on a rat for no reason other than her own apparent amusement.
101	* [[spoiler:Dr. Akihiro Kanou]] from ''Manga/TokyoGhoul''. [[spoiler: When confronted about ''intentionally'' turning Ken Kaneki into a HalfHumanHybrid, he makes a speech about being AboveGoodAndEvil. His experiments have left dozens of innocent people either mutated into mentally disabled freaks of nature or dead, with only ''four'' known successes]]. In response, Kaneki calls him a [[PrecisionFStrike fucking]] lunatic.
102	* Dr. Karigari from ''Anime/TomicaHyperRescueDriveHeadKidouKyuukyuuKeisatsu''. While he isn't technically evil and is prone to [[VillainousRescue helping the heroes]], he is incredibly petty, which makes him dangerous. He is a super genius who can [[GadgeteerGenius invent anything]] he needs to help with his revenge plans, and seems to particularly favor manipulating the weather.
103	* In ''Anime/ValvraveTheLiberator'', we have Dr. Tokshima, a man responsible for creating what he calls a new life form, "homo sapiens novus", and is completely happy that they are superior to humanity. He laughs constantly, and compares himself to god in a somewhat funny, somewhat disturbing fashion, because its less of a dramatic declaration and more of a question he asks himself logically.
104	** When he boasts about his son, Haruto, to his colleagues, he is holding a picture frame of what seemed to be a picture of Haruto. Except it's not a picture of Haruto in person. It's Haruto's genetic map. Even his colleagues are disturbed by that.
105	* In ''Anime/YuGiOh5Ds'', Akutsu (the scientist who developed the current Momentum generator) was certainly nutty enough to fit the Trope (and he did work for the BigBad of Season 1), but he seemed harmless.
106	* Yoshizumi-sensei of ''Manga/ZombieLoan''. He started off as a reasonably sane college scientist, but when [[spoiler:Caramelo]] of the ARRC turned him into a zombie, he [[GoMadFromTheRevelation snapped]]. He ends up [[spoiler:merging with his "masterwork", the Phalanx, only to be killed by Sawatari.]]
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Context MadScientist / AnimeAndManga