I have sort-of base characters on real people, altough not often. Phil from Forgotten Lore shares some traits with me, but his personality isn't very similar. He's more of a generic geeky guy than a self-insert, but since I am a geeky guy, he ended up with lots of the same traits.
Zaran from Forgotten Lore is also essentially a combination of two characters from an earlier version of the story, one of which was based on a real person. The final result doesn't really have much in common with the actual person, beyond some very basic traits (they're both cheerful and impulsive). If I was doing something with voice acting the similarity might be noticeable because I picture Zaran having a similar, rather distinctive, way of speaking.
Also, I did name one character after my friend. Well, perhaps a character isn't really an accurate term, as it's more of a case of one of the characters mentioning the name of his friend who doesn't actually appear in the comic at all. I didn't bother to spend a long time trying to come up with a good name so I just used a variation of the name of a real-life friend.